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> Protein (NX_Q05513)
Protein (NX_Q05513)
Protein
Gene SymbolPRKCZ to neXtProt (NX_Q05513)
DescriptionProtein kinase C zeta type
Chromosome1
Location1p36.33 (1981909 ~ 2116834) to Ensembl
Sequene Features : Isoforms 3, Variants 62, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of interleukin-10 secretion
.positive regulation of interleukin-13 secretion
.positive regulation of interleukin-5 secretion
  + 38 more...
.metal ion binding
.insulin receptor substrate binding
.potassium channel regulator activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical cortex
  + 17 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 62 2
2014-09-19protein level
3 48 2
2014-05-27protein level
3 48 3
2014-02-25protein level
3 48 3
2013-12-09protein level
3 37 3
2013-11-01protein level
3 34 3
2013-09-12protein level
3 34 3
2013-08-17protein level
3 34 3
2013-07-15protein level
3 24 3
2013-06-11protein level
3 24 3
2013-02-12protein level
2 18 6
2012-12-20protein level
2 18 6
2012-10-30protein level
2 18 6
2012-10-07protein level
2 18 3
2012-08-24protein level
2 18 3
2012-07-28protein level
2 18 3
2012-06-08protein level
2 27 3
2012-05-07protein level
2 19 3
2012-04-10protein level
2 19 3
2012-01-13protein level
2 15 3
2011-12-20protein level
2 15 3
2011-11-11protein level
2 15 3
2011-08-23protein level
1 15 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q05513-1
4 20 1 67616.5019
NX_Q05513-2
1 16 1 46592.052
NX_Q05513-3
0 20 1 56099.9999
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-295351,EBI-958922 BCL10  
  .positive regulation of extrinsic apoptotic signaling pathway
.cellular response to mechanical stimulus
.T cell apoptotic process
  + 29 more...
.NF-kappaB binding
.protein self-association
.protein kinase B binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 8 more...
2 EBI-295351,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
3 EBI-295351,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
4 EBI-295351,EBI-301246 VHL  
  .cellular response to hypoxia
.negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 10 more...
.ubiquitin protein ligase activity
.enzyme binding
.transcription factor binding
.ubiquitin-protein transferase activity
.intermediate filament cytoskeleton
.VCB complex
.membrane
  + 5 more...
5 EBI-295351,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
6 EBI-295351,EBI-7199607 NUMB  
  .negative regulation of protein localization to plasma membrane
.lung epithelial cell differentiation
.positive regulation of neurogenesis
  + 8 more...
.N/A .apical part of cell
.clathrin-coated vesicle
.extrinsic component of plasma membrane
  + 6 more...
7 EBI-295351,EBI-374762 PRKCQ  
  .positive regulation of T-helper 2 cell activation
.positive regulation of T-helper 17 type immune response
.regulation of platelet aggregation
  + 26 more...
.metal ion binding
.ATP binding
.ubiquitin-protein transferase activity
  + 2 more...
.plasma membrane
.cytosol
.immunological synapse
8 EBI-295351,EBI-347528 C1QBP  
  .positive regulation of dendritic cell chemotaxis
.positive regulation of trophoblast cell migration
.positive regulation of substrate adhesion-dependent cell spreading
  + 25 more...
.mitochondrial ribosome binding
.adrenergic receptor binding
.kininogen binding
  + 5 more...
.membrane
.cell surface
.plasma membrane
  + 7 more...
9 EBI-295351,EBI-295417 PARD6G  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 2 more...
.N/A .protein complex
.tight junction
.plasma membrane
.cytosol
10 EBI-295351,EBI-295391 PARD6B  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 7 more...
.N/A .extracellular exosome
.apical part of cell
.protein complex
  + 6 more...
11 EBI-295351,EBI-81876 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
12 EBI-295351,EBI-742600 F11R  
  .regulation of actin cytoskeleton reorganization
.regulation of membrane permeability
.establishment of endothelial intestinal barrier
  + 17 more...
.PDZ domain binding .extracellular exosome
.slit diaphragm
.cytoplasmic vesicle
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain454
cervix20
connective tissue33
embryonic tissue23
eye81
heart44
intestine77
kidney128
liver14
lung29
lymph293
lymph node55
mammary gland85
mouth30
nerve64
ovary78
pancreas32
parathyroid194
pituitary gland181
placenta759
prostate26
skin18
spleen37
stomach20
testis135
thymus50
thyroid21
uterus25
Health State
TissuesTPM*
normal237
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma36
colorectal tumor79
gastrointestinal tumor8
germ cell tumor68
glioma74
head and neck tumor22
kidney tumor304
leukemia42
liver tumor20
lung tumor38
lymphoma193
non-neoplasia134
ovarian tumor78
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer9
retinoblastoma43
skin tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult166
embryoid body42
blastocyst16
fetus149
infant425
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.6
adrenal gland14.1
appendix7
bone marrow2
cerebral cortex66.2
colon15.8
duodenum34.1
esophagus22.5
gallbladder9.2
heart muscle10.4
kidney22.2
liver7.9
lung40.7
lymph node11.4
ovary2.4
pancreas8.9
placenta58.7
prostate11.9
salivary gland9.9
skin23.6
small intestine31.6
spleen12.3
stomach11.1
testis55.9
thyroid gland31.8
urinary bladder9.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
colonMedium
duodenumLow
endometrium 1Low
epididymisLow
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungLow
lymph nodeLow
pancreasHigh
parathyroid glandLow
placentaHigh
prostateHigh
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
small intestineMedium
soft tissue 1Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176982, gene) Protein kinase c, zeta form; PRKCZOMIM


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