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> Protein (NX_Q05655)
Protein (NX_Q05655)
Protein
Gene SymbolPRKCD to neXtProt (NX_Q05655)
DescriptionProtein kinase C delta type
Chromosome3
Location3p21.1 (53190025 ~ 53226733) to Ensembl
Sequene Features : Isoforms 2, Variants 69, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.positive regulation of response to DNA damage stimulus
.positive regulation of sphingomyelin catabolic process
  + 46 more...
.metal ion binding
.insulin receptor substrate binding
.enzyme binding
  + 6 more...
.extracellular exosome
.perinuclear region of cytoplasm
.nuclear matrix
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 69 24
2014-09-19protein level
2 56 24
2014-05-27protein level
2 56 24
2014-02-25protein level
2 56 24
2013-12-09protein level
2 49 24
2013-11-01protein level
2 44 21
2013-09-12protein level
2 44 21
2013-08-17protein level
2 44 21
2013-07-15protein level
2 29 21
2013-06-11protein level
2 29 21
2013-02-12protein level
2 23 48
2012-12-20protein level
2 23 48
2012-10-30protein level
2 24 48
2012-10-07protein level
2 24 24
2012-08-24protein level
2 23 24
2012-07-28protein level
2 23 24
2012-06-08protein level
2 10 24
2012-05-07protein level
1 19 24
2012-04-10protein level
1 19 24
2012-01-13protein level
1 23 24
2011-12-20protein level
1 21 21
2011-11-11protein level
1 21 21
2011-08-23protein level
1 21 21
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q05655-1
1 30 3 77454.6616
NX_Q05655-2
4 30 3 80900.4532
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-704279,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-704279,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
3 EBI-704279,EBI-539628 TOP2A  
  .rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
  + 16 more...
.protein heterodimerization activity
.poly(A) RNA binding
.ubiquitin binding
  + 13 more...
.protein complex
.DNA topoisomerase complex (ATP-hydrolyzing)
.cytoplasm
  + 4 more...
4 EBI-704279,EBI-1267511 GAP43  
  .axon development
.regulation of filopodium assembly
.cell fate commitment
  + 6 more...
.calmodulin binding .growth cone membrane
.filopodium membrane
.axon
  + 4 more...
5 EBI-704279,EBI-489611 NCF2  
  .phagosome maturation
.response to hyperoxia
.interaction with host
  + 20 more...
.electron carrier activity
.protein C-terminus binding
.NADPH oxidase complex
.phagolysosome
.cytosol
  + 3 more...
6 EBI-704279,EBI-8800907 IL32  
  .cell adhesion
.immune response
.defense response
.N/A .membrane
.extracellular space
7 EBI-704279,EBI-517508 DIABLO  
  .intrinsic apoptotic signaling pathway
.neuron apoptotic process
.positive regulation of apoptotic process
  + 6 more...
.N/A .CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites677
blood106
bone27
bone marrow20
brain11
cervix61
connective tissue20
embryonic tissue28
eye4
heart11
intestine68
kidney28
larynx42
liver4
lung65
lymph248
lymph node66
mammary gland85
mouth60
nerve128
ovary98
pancreas56
parathyroid97
pharynx24
placenta21
prostate79
salivary gland49
skin42
spleen56
testis71
thyroid64
trachea19
uterus38
vascular38
Health State
TissuesTPM*
normal30
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma48
colorectal tumor106
gastrointestinal tumor227
germ cell tumor18
glioma9
head and neck tumor59
kidney tumor43
leukemia116
liver tumor10
lung tumor29
lymphoma304
non-neoplasia20
ovarian tumor118
pancreatic tumor66
prostate cancer86
skin tumor71
soft tissue/muscle tissue tumor23
uterine tumor77
Developmental Stage
TissuesTPM*
adult60
embryoid body28
blastocyst32
neonate32
fetus30
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.8
adrenal gland45.5
appendix33.7
bone marrow38.3
cerebral cortex9.2
colon31.6
duodenum38.1
esophagus23.6
gallbladder28.9
heart muscle10.6
kidney19.6
liver4.1
lung31.8
lymph node36.5
ovary10.6
pancreas13.1
placenta14.2
prostate28.8
salivary gland17
skin20.6
small intestine38.2
spleen29.9
stomach43.3
testis18.7
thyroid gland33
urinary bladder33.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastLow
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverLow
lungHigh
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Low
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176977, gene) Protein kinase c, delta; PRKCDOMIM


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