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> Protein (NX_Q06124)
Protein (NX_Q06124)
Protein
Gene SymbolPTPN11 to neXtProt (NX_Q06124)
DescriptionTyrosine-protein phosphatase non-receptor type 11
Chromosome12
Location12q24.13 (112856155 ~ 112947717) to Ensembl
Sequene Features : Isoforms 3, Variants 149, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 149 12
2014-09-19protein level
3 136 12
2014-05-27protein level
3 136 12
2014-02-25protein level
3 136 13
2013-12-09protein level
3 129 13
2013-11-01protein level
3 126 12
2013-09-12protein level
3 126 12
2013-08-17protein level
3 126 12
2013-07-15protein level
3 103 10
2013-06-11protein level
3 103 10
2013-02-12protein level
3 83 20
2012-12-20protein level
3 83 20
2012-10-30protein level
3 84 20
2012-10-07protein level
3 84 8
2012-08-24protein level
3 84 8
2012-07-28protein level
3 84 8
2012-06-08protein level
3 57 8
2012-05-07protein level
3 57 8
2012-04-10protein level
3 57 8
2012-01-13protein level
3 57 8
2011-12-20protein level
3 57 8
2011-11-11protein level
3 57 8
2011-08-23protein level
3 56 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q06124-1
1 31 0 68393.1277
NX_Q06124-2
0 32 0 67967.8652
NX_Q06124-3
1 24 0 52794.3277
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297779,EBI-963338 MPZL1  
  .cell-cell signaling
.transmembrane receptor protein tyrosine kinase signaling pathway
.structural molecule activity .cell surface
.focal adhesion
.integral component of plasma membrane
2 EBI-297779,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-297779,EBI-475899 INSR  
  .cellular response to growth factor stimulus
.positive regulation of respiratory burst
.positive regulation of protein kinase B signaling
  + 31 more...
.PTB domain binding
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.extracellular exosome
.receptor complex
.intracellular membrane-bounded organelle
  + 6 more...
4 EBI-297779,EBI-475981 IGF1R  
  .positive regulation of steroid hormone biosynthetic process
.prostate gland epithelium morphogenesis
.negative regulation of protein kinase B signaling
  + 30 more...
.insulin receptor substrate binding
.insulin binding
.phosphatidylinositol 3-kinase binding
  + 7 more...
.receptor complex
.intracellular membrane-bounded organelle
.neuron projection
  + 4 more...
5 EBI-297779,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
6 EBI-297779,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
7 EBI-297779,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
8 EBI-297779,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
9 EBI-297779,EBI-716404 PECAM1  
  .glomerular endothelium development
.diapedesis
.leukocyte migration
  + 8 more...
.N/A .extracellular exosome
.platelet alpha granule membrane
.cell junction
  + 3 more...
10 EBI-297779,EBI-1026718 FLT1  
  .embryonic morphogenesis
.blood vessel morphogenesis
.vascular endothelial growth factor receptor signaling pathway
  + 20 more...
.placental growth factor-activated receptor activity
.VEGF-B-activated receptor activity
.VEGF-A-activated receptor activity
  + 4 more...
.receptor complex
.focal adhesion
.integral component of plasma membrane
  + 3 more...
11 EBI-297779,EBI-3906571 CD33  
  .negative regulation of cell proliferation
.cell-cell signaling
.signal transduction
.cell adhesion
.carbohydrate binding
.receptor activity
.extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
12 EBI-297779,EBI-1753137 CCKBR  
  .gland development
.digestive tract development
.regulation of phosphatidylinositol 3-kinase activity
  + 11 more...
.1-phosphatidylinositol-3-kinase regulator activity
.type B gastrin/cholecystokinin receptor binding
.gastrin receptor activity
  + 2 more...
.integral component of plasma membrane
.plasma membrane
13 EBI-297779,EBI-517592 IRS1  
  .positive regulation of glucose import in response to insulin stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.phosphatidylinositol-mediated signaling
  + 29 more...
.phosphatidylinositol 3-kinase binding
.SH2 domain binding
.insulin-like growth factor receptor binding
  + 4 more...
.intracellular membrane-bounded organelle
.ciliary basal body
.caveola
  + 5 more...
14 EBI-297779,EBI-8632435 KIR2DL3  
  .regulation of immune response
.immune response
.receptor activity
.antigen binding
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
15 EBI-297779,EBI-702209 PXN  
  .growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
16 EBI-297779,EBI-744831 RPIA  
  .small molecule metabolic process
.pentose-phosphate shunt, non-oxidative branch
.pentose-phosphate shunt
.carbohydrate metabolic process
.monosaccharide binding
.ribose-5-phosphate isomerase activity
.intracellular membrane-bounded organelle
.cytosol
17 EBI-297779,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
18 EBI-297779,EBI-711879 DDR1  
  .smooth muscle cell-matrix adhesion
.mammary gland alveolus development
.branching involved in mammary gland duct morphogenesis
  + 14 more...
.metal ion binding
.protein tyrosine kinase collagen receptor activity
.ATP binding
  + 2 more...
.extracellular exosome
.receptor complex
.integral component of plasma membrane
  + 2 more...
19 EBI-297779,EBI-742790 TRIM32  
  .positive regulation of cell motility
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of viral release from host cell
  + 21 more...
.ubiquitin protein ligase activity
.protein self-association
.ubiquitin binding
  + 8 more...
.striated muscle myosin thick filament
.cytosol
.cytoplasm
.nucleus
20 EBI-297779,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
21 EBI-297779,EBI-975200 GAB2  
  .phosphatidylinositol-mediated signaling
.innate immune response
.positive regulation of mast cell degranulation
  + 6 more...
.phosphatidylinositol-3,4-bisphosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder33
blood8
bone111
bone marrow20
brain68
cervix103
connective tissue80
ear62
embryonic tissue136
esophagus49
eye47
heart78
intestine47
kidney56
larynx170
liver43
lung38
lymph45
lymph node100
mammary gland46
mouth60
muscle56
nerve193
ovary68
pancreas32
parathyroid242
pharynx49
placenta35
prostate63
skin118
spleen37
stomach73
testis29
thymus50
thyroid107
uterus116
Health State
TissuesTPM*
normal57
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma144
colorectal tumor53
esophageal tumor57
gastrointestinal tumor75
germ cell tumor64
glioma74
head and neck tumor74
kidney tumor58
liver tumor62
lung tumor68
lymphoma27
non-neoplasia113
ovarian tumor91
pancreatic tumor9
primitive neuroectodermal tumor of the CNS62
prostate cancer77
retinoblastoma150
skin tumor167
soft tissue/muscle tissue tumor127
uterine tumor77
Developmental Stage
TissuesTPM*
adult57
embryoid body157
blastocyst130
neonate64
fetus73
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue40.8
adrenal gland29.9
appendix26.1
bone marrow15.7
cerebral cortex53.2
colon24.4
duodenum17.1
esophagus28.8
gallbladder24.2
heart muscle41.9
kidney27.6
liver24
lung24
lymph node25.4
ovary18
pancreas10.9
placenta26.2
prostate27.2
salivary gland14.5
skin18.3
small intestine17.4
spleen17.7
stomach18.9
testis13.1
thyroid gland33.9
urinary bladder29.2
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungHigh
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#151100, phenotype) Leopard syndrome 1OMIM
2(#156250, phenotype) Metachondromatosis; METCDSOMIM
3(#163950, phenotype) Noonan syndrome 1; NS1OMIM
4(*176876, gene) Protein-tyrosine phosphatase, nonreceptor-type, 11; PTPN11OMIM
5(#607785, phenotype) Juvenile myelomonocytic leukemia; JMMLOMIM
6juvenile myelomonocytic leukemia;acute myelogenous leukemia;myelodysplastic syndrome;Noonan SyndromeCGP


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