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> Protein (NX_Q06330)
Protein (NX_Q06330)
Protein
Gene SymbolRBPJ to neXtProt (NX_Q06330)
DescriptionRecombining binding protein suppressor of hairless
Chromosome4
Location4p15.2 (26165077 ~ 26436541) to Ensembl
Sequene Features : Isoforms 7, Variants 62, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cell proliferation involved in heart morphogenesis
.positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
.positive regulation of ephrin receptor signaling pathway
  + 46 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 7 more...
.cytoplasm
.nucleolus
.transcription factor complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 62 1
2014-09-19protein level
7 50 1
2014-05-27protein level
7 50 1
2014-02-25protein level
7 50 0
2013-12-09protein level
7 39 0
2013-11-01protein level
7 38 0
2013-09-12protein level
7 38 0
2013-08-17protein level
7 38 0
2013-07-15protein level
7 27 0
2013-06-11protein level
7 27 0
2013-02-12protein level
7 17 0
2012-12-20protein level
7 18 0
2012-10-30protein level
7 17 0
2012-10-07protein level
7 17 0
2012-08-24protein level
7 17 0
2012-07-28protein level
7 17 0
2012-06-08protein level
7 14 0
2012-05-07protein level
7 14 0
2012-04-10protein level
7 14 0
2012-01-13protein level
6 14 0
2011-12-20protein level
6 14 0
2011-11-11protein level
6 14 0
2011-08-23protein level
6 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q06330-1
1 19 1 55601.3759
NX_Q06330-2
0 16 1 47150.1381
NX_Q06330-3
1 15 1 45612.5285
NX_Q06330-4
0 19 1 54110.7306
NX_Q06330-5
0 18 1 51843.5483
NX_Q06330-6
0 19 1 54391.973
NX_Q06330-7
1 19 1 54261.8728
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-632552,EBI-8624731 ATXN1L  
  .positive regulation of hematopoietic stem cell proliferation
.lung alveolus development
.extracellular matrix organization
  + 2 more...
.RNA binding
.DNA binding
.dendrite
.nucleolus
.nucleus
2 EBI-632552,EBI-636374 NOTCH1  
  .negative regulation of endothelial cell chemotaxis
.negative regulation of pro-B cell differentiation
.negative regulation of anoikis
  + 125 more...
.sequence-specific DNA binding
.chromatin DNA binding
.enzyme binding
  + 6 more...
.receptor complex
.integral component of membrane
.cell surface
  + 9 more...
3 EBI-632552,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
4 EBI-632552,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
5 EBI-632552,EBI-2836148 RITA1  
  .nuclear export
.negative regulation of Notch signaling pathway
.neurogenesis
  + 2 more...
.tubulin binding .centrosome
.Golgi apparatus
.cytoplasm
  + 2 more...
6 EBI-632552,EBI-80830 NCOR2  
  .regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
.small molecule metabolic process
.cellular lipid metabolic process
  + 7 more...
.protein N-terminus binding
.histone deacetylase binding
.Notch binding
  + 3 more...
.transcriptional repressor complex
.nuclear body
.nuclear matrix
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland121
ascites75
bladder66
blood171
bone97
bone marrow184
brain113
cervix164
connective tissue134
ear62
embryonic tissue192
eye138
heart78
intestine77
kidney80
liver151
lung113
lymph180
lymph node133
mammary gland105
mouth226
muscle197
nerve193
ovary68
pancreas51
parathyroid97
pharynx319
pituitary gland242
placenta158
prostate105
salivary gland49
skin94
spleen187
stomach219
testis119
thymus238
thyroid42
trachea77
uterus146
vascular77
Health State
TissuesTPM*
normal127
adrenal tumor158
breast (mammary gland) tumor107
chondrosarcoma181
colorectal tumor62
gastrointestinal tumor194
germ cell tumor170
glioma121
head and neck tumor97
kidney tumor58
leukemia148
liver tumor135
lung tumor97
lymphoma138
non-neoplasia134
ovarian tumor52
pancreatic tumor19
primitive neuroectodermal tumor of the CNS165
prostate cancer86
retinoblastoma193
skin tumor95
soft tissue/muscle tissue tumor79
uterine tumor144
Developmental Stage
TissuesTPM*
adult134
embryoid body142
blastocyst227
neonate225
fetus140
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue44.3
adrenal gland22.5
appendix45.9
bone marrow54.3
cerebral cortex34.5
colon30
duodenum27.8
esophagus46.7
gallbladder50
heart muscle22.3
kidney21
liver11.1
lung33.8
lymph node39.1
ovary45.2
pancreas12.6
placenta53.6
prostate32.5
salivary gland17.9
skin26
small intestine30.2
spleen29.2
stomach29.3
testis34.7
thyroid gland44.7
urinary bladder54.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*147183, gene) Recombination signal-binding protein for immunoglobulin kappa j region;OMIM
2(#614814, phenotype) Adams-oliver syndrome 3; AOS3OMIM


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