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> Protein (NX_Q06455)
Protein (NX_Q06455)
Protein
Gene SymbolRUNX1T1 to neXtProt (NX_Q06455)
DescriptionProtein CBFA2T1
Chromosome8
Location8q21.3 (92967203 ~ 93115514) to Ensembl
Sequene Features : Isoforms 4, Variants 193, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
.mitochondrion
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 193 5
2014-09-19protein level
4 123 5
2014-05-27protein level
4 122 5
2014-02-25protein level
4 120 5
2013-12-09protein level
4 113 5
2013-11-01protein level
4 110 5
2013-09-12protein level
4 110 5
2013-08-17protein level
4 110 5
2013-07-15protein level
4 81 5
2013-06-11protein level
4 81 5
2013-02-12protein level
3 25 18
2012-12-20protein level
3 24 18
2012-10-30protein level
2 25 12
2012-10-07protein level
2 25 6
2012-08-24protein level
2 7 6
2012-07-28protein level
2 7 6
2012-06-08protein level
2 21 6
2012-05-07protein level
2 21 6
2012-04-10protein level
2 21 6
2012-01-13protein level
2 23 6
2011-12-20protein level
2 23 6
2011-11-11protein level
2 23 6
2011-08-23protein level
2 23 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q06455-1
2 23 5 67524.1593
NX_Q06455-2
0 23 5 64355.5249
NX_Q06455-3
2 23 5 68702.7323
NX_Q06455-4
1 22 5 63172.9831
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10224192,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-10224192,EBI-744222 LPXN  
  .negative regulation of B cell receptor signaling pathway
.regulation of cell adhesion mediated by integrin
.signal transduction
  + 5 more...
.zinc ion binding
.transcription cofactor activity
.perinuclear region of cytoplasm
.cell projection
.membrane
  + 5 more...
3 EBI-10224192,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
4 EBI-743342,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-10224192,EBI-741210 C19orf57  
  .multicellular organismal development .N/A .N/A
6 EBI-10224192,EBI-375576 EPS8  
  .actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
7 EBI-10224192,EBI-372619 GSE1  
  .N/A .N/A .N/A
8 EBI-10224192,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
9 EBI-10224192,EBI-2514659 ZMYM4  
  .regulation of cell morphogenesis
.multicellular organismal development
.cytoskeleton organization
.zinc ion binding
.DNA binding
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
10 EBI-10224192,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
11 EBI-10224192,EBI-746909 CPSF7  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.membrane
.mRNA cleavage factor complex
.nucleoplasm
.nucleus
12 EBI-10224192,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
13 EBI-10224192,EBI-6942903 CREB3L1  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.extracellular matrix constituent secretion
  + 3 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.cAMP response element binding
  + 2 more...
.integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
.nucleus
14 EBI-10224192,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
15 EBI-10224192,EBI-3957793 PRDM14  
  .homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleoplasm
16 EBI-10224192,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
17 EBI-10224192,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bone27
brain7
connective tissue13
embryonic tissue23
eye19
heart78
kidney18
lung17
mammary gland6
muscle47
ovary9
pancreas89
pharynx24
placenta3
prostate26
skin18
spleen18
testis9
thyroid21
uterus4
vascular19
Health State
TissuesTPM*
normal2
adrenal tumor79
chondrosarcoma36
germ cell tumor41
head and neck tumor7
kidney tumor43
ovarian tumor13
pancreatic tumor66
primitive neuroectodermal tumor of the CNS15
soft tissue/muscle tissue tumor47
Developmental Stage
TissuesTPM*
adult15
neonate32
fetus16
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.6
adrenal gland3
appendix3.1
cerebral cortex5.9
colon2.8
duodenum1.1
esophagus3.2
gallbladder9.7
heart muscle8
kidney1.9
lung5.5
lymph node1.7
ovary5.7
placenta4.9
prostate3.4
salivary gland2.7
skin2.2
small intestine1.7
spleen2.8
stomach2.6
testis5.2
thyroid gland3.3
urinary bladder4.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#114500, phenotype) Colorectal cancer; CRCOMIM
2(*133435, gene) Runt-related transcription factor 1, translocated to, 1; RUNX1T1OMIM


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