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> Protein (NX_Q06547)
Protein (NX_Q06547)
Protein
Gene SymbolGABPB1 to neXtProt (NX_Q06547)
DescriptionGA-binding protein subunit beta-1
Chromosome15
Location15q21.2 (50569389 ~ 50647605) to Ensembl
Sequene Features : Isoforms 4, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.mitochondrion organization
.organelle organization
  + 2 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 34 1
2014-09-19protein level
4 25 1
2014-05-27protein level
4 25 1
2014-02-25protein level
4 26 1
2013-12-09protein level
4 25 1
2013-11-01protein level
4 24 1
2013-09-12protein level
4 24 0
2013-08-17protein level
4 24 0
2013-07-15protein level
4 17 0
2013-06-11protein level
4 17 0
2013-02-12protein level
4 8 0
2012-12-20protein level
4 8 0
2012-10-30protein level
4 6 0
2012-10-07protein level
4 6 0
2012-08-24protein level
4 3 0
2012-07-28protein level
4 3 0
2012-06-08protein level
4 15 0
2012-05-07protein level
4 15 0
2012-04-10protein level
4 15 0
2012-01-13protein level
4 15 0
2011-12-20protein level
4 15 0
2011-11-11protein level
4 15 0
2011-08-23protein level
4 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q06547-1
0 11 1 42456.4599
NX_Q06547-2
0 10 1 41295.8959
NX_Q06547-3
0 11 1 38087.2828
NX_Q06547-4
0 10 1 36926.7188
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-618165,EBI-1053651 SNRPB2  
  .gene expression
.RNA splicing
.mRNA processing
  + 2 more...
.snRNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nucleolus
.U2 snRNP
  + 2 more...
2 EBI-618165,EBI-607085 SNRPA  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.snRNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleolus
.U1 snRNP
  + 2 more...
3 EBI-618165,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
4 EBI-618189,EBI-396176 HCFC1  
  .protein stabilization
.positive regulation of cell cycle
.histone H4-K16 acetylation
  + 12 more...
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.MLL1 complex
.MLL5-L complex
.Set1C/COMPASS complex
  + 7 more...
5 EBI-618165,EBI-741332 RBM11  
  .cellular response to oxidative stress
.cell differentiation
.RNA splicing
  + 3 more...
.protein homodimerization activity
.poly(U) RNA binding
.nucleotide binding
.nuclear speck
.nucleoplasm
.nucleus
6 EBI-618165,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
7 EBI-618165,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
8 EBI-618165,EBI-1389308 POGZ  
  .kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
9 EBI-618165,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
10 EBI-618165,EBI-624505 TDRD7  
  .lens fiber cell differentiation
.posttranscriptional regulation of gene expression
.spermatogenesis
  + 2 more...
.mRNA binding .P granule
.ribonucleoprotein granule
.chromatoid body
  + 2 more...
11 EBI-618165,EBI-741835 MAGEB18  
  .N/A .N/A .cytoplasm
12 EBI-618165,EBI-748350 RTDR1  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
bone55
bone marrow82
brain20
cervix61
connective tissue46
embryonic tissue28
eye28
heart22
intestine25
kidney23
larynx42
liver34
lung14
lymph node144
mammary gland52
mouth45
muscle18
pancreas18
pharynx49
pituitary gland60
placenta45
prostate42
skin28
spleen18
stomach31
testis29
thymus25
trachea19
uterus47
vascular77
Health State
TissuesTPM*
normal32
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor16
germ cell tumor64
head and neck tumor37
kidney tumor58
leukemia84
liver tumor10
lung tumor9
non-neoplasia20
primitive neuroectodermal tumor of the CNS47
prostate cancer48
skin tumor39
soft tissue/muscle tissue tumor39
uterine tumor22
Developmental Stage
TissuesTPM*
adult38
blastocyst32
neonate32
fetus23
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.2
adrenal gland6.8
appendix13.4
bone marrow17.2
cerebral cortex4.3
colon8.3
duodenum6.3
esophagus9
gallbladder9.2
heart muscle4.8
kidney4.9
liver5.5
lung7.6
lymph node16.5
ovary6.9
pancreas2.9
placenta13.1
prostate8.3
salivary gland5.3
skin5
small intestine6.3
spleen8.9
stomach7.5
testis13.7
thyroid gland7.9
urinary bladder10.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600610, gene) Ga-binding protein transcription factor, beta subunit; GABPBOMIM


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