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> Protein (NX_Q06609)
Protein (NX_Q06609)
Protein
Gene SymbolRAD51 to neXtProt (NX_Q06609)
DescriptionDNA repair protein RAD51 homolog 1
Chromosome15
Location15q15.1 (40986972 ~ 41024354) to Ensembl
Sequene Features : Isoforms 4, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to camptothecin
.cellular response to ionizing radiation
.protein homooligomerization
  + 12 more...
.DNA polymerase binding
.single-stranded DNA-dependent ATPase activity
.identical protein binding
  + 5 more...
.perinuclear region of cytoplasm
.PML body
.microtubule organizing center
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 30 6
2014-09-19protein level
4 25 6
2014-05-27protein level
4 25 6
2014-02-25protein level
4 25 6
2013-12-09protein level
4 17 6
2013-11-01protein level
4 17 4
2013-09-12protein level
4 17 3
2013-08-17protein level
4 17 3
2013-07-15protein level
4 11 2
2013-06-11protein level
4 11 2
2013-02-12protein level
4 6 7
2012-12-20protein level
4 7 7
2012-10-30protein level
4 9 7
2012-10-07protein level
4 9 2
2012-08-24protein level
4 9 2
2012-07-28protein level
4 9 2
2012-06-08protein level
4 12 2
2012-05-07protein level
4 11 2
2012-04-10protein level
3 9 2
2012-01-13protein level
3 11 2
2011-12-20protein level
3 11 2
2011-11-11protein level
3 11 2
2011-08-23protein level
2 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q06609-1
0 14 0 36942.5964
NX_Q06609-2
0 9 0 26334.2462
NX_Q06609-3
2 11 0 30981.6363
NX_Q06609-4
3 11 0 36756.3867
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297202,EBI-974488 CHEK1  
  .regulation of histone H3-K9 acetylation
.negative regulation of DNA biosynthetic process
.replicative senescence
  + 17 more...
.histone kinase activity (H3-T11 specific)
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.intracellular membrane-bounded organelle
.cytosol
.centrosome
  + 6 more...
2 EBI-297202,EBI-2267048 RAD51C  
  .positive regulation of G2/M transition of mitotic cell cycle
.blood coagulation
.spermatogenesis
  + 8 more...
.crossover junction endodeoxyribonuclease activity
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.perinuclear region of cytoplasm
.Rad51C-XRCC3 complex
.Rad51B-Rad51C-Rad51D-XRCC2 complex
  + 5 more...
3 EBI-297202,EBI-2849976 XRCC3  
  .positive regulation of mitotic cell cycle spindle assembly checkpoint
.resolution of mitotic recombination intermediates
.regulation of centrosome duplication
  + 5 more...
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.perinuclear region of cytoplasm
.Rad51C-XRCC3 complex
.mitochondrion
  + 3 more...
4 EBI-297202,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
5 EBI-297202,EBI-9057228 NAT2  
  .small molecule metabolic process
.xenobiotic metabolic process
.arylamine N-acetyltransferase activity .cytosol
6 EBI-297202,EBI-706448 RAD52  
  .regulation of nucleotide-excision repair
.cellular protein metabolic process
.post-translational protein modification
  + 9 more...
.identical protein binding
.DNA binding
.recombinase activity
.nucleoplasm
.nucleus
7 EBI-297202,EBI-79792 BRCA2  
  .centrosome duplication
.replication fork protection
.positive regulation of mitotic cell cycle
  + 23 more...
.gamma-tubulin binding
.H4 histone acetyltransferase activity
.H3 histone acetyltransferase activity
  + 2 more...
.protein complex
.BRCA2-MAGE-D1 complex
.secretory granule
  + 4 more...
8 EBI-297202,EBI-3915542 IL24  
  .cellular response to interleukin-4
.cellular response to lipopolysaccharide
.positive regulation of JAK-STAT cascade
  + 11 more...
.cytokine activity .endoplasmic reticulum
.extracellular space
9 EBI-297202,EBI-5281637 SWSAP1  
  .protein stabilization
.double-strand break repair via homologous recombination
.ATPase activity
.single-stranded DNA binding
.Shu complex
.nucleus
10 EBI-297202,EBI-1222653 PALB2  
  .negative regulation of apoptotic process
.post-anal tail morphogenesis
.organ morphogenesis
  + 5 more...
.DNA binding .nucleoplasm
11 EBI-297202,EBI-1178743 RAD51AP1  
  .cellular response to ionizing radiation
.regulation of double-strand break repair via homologous recombination
.DNA repair
.double-strand break repair via homologous recombination
.RNA binding
.single-stranded DNA binding
.double-stranded DNA binding
.nucleus
12 EBI-297202,EBI-9057780 FAM84B  
  .N/A .N/A .plasma membrane
.cytoplasm
13 EBI-297202,EBI-3390132 WHSC1L1  
  .negative regulation of transcription, DNA-templated
.histone methylation
.transcription, DNA-templated
.chromatin organization
.histone methyltransferase activity (H3-K27 specific)
.histone methyltransferase activity (H3-K4 specific)
.histone-lysine N-methyltransferase activity
.zinc ion binding
.chromosome
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
blood16
bone13
bone marrow82
brain18
embryonic tissue37
eye28
heart11
intestine47
kidney14
liver4
lung2
lymph22
mammary gland26
muscle37
ovary49
pancreas9
pharynx24
placenta38
prostate10
skin28
stomach31
testis50
thymus50
uterus30
Health State
TissuesTPM*
normal13
adrenal tumor158
breast (mammary gland) tumor10
colorectal tumor53
gastrointestinal tumor50
germ cell tumor45
glioma18
head and neck tumor7
kidney tumor43
lymphoma41
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS196
prostate cancer19
retinoblastoma107
skin tumor47
soft tissue/muscle tissue tumor63
uterine tumor11
Developmental Stage
TissuesTPM*
adult17
embryoid body28
blastocyst65
fetus12
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.1
appendix8.1
bone marrow12.3
colon9.4
duodenum2.6
esophagus4.5
gallbladder2.8
liver1.3
lung1.6
lymph node13.4
placenta8.2
prostate1.1
skin3.2
small intestine5
spleen2.3
stomach3.8
testis25.4
urinary bladder3
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowHigh
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusMedium
fallopian tubeMedium
gallbladderLow
heart muscleLow
hippocampusLow
kidneyLow
lateral ventricleLow
liverLow
lungLow
lymph nodeHigh
nasopharynxLow
oral mucosaLow
ovaryLow
pancreasLow
parathyroid glandLow
placentaMedium
prostateLow
rectumLow
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Low
stomach 2Low
testisHigh
thyroid glandLow
tonsilHigh
urinary bladderLow
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#114480, phenotype) Breast cancerOMIM
2(*179617, gene) Rad51, s. cerevisiae, homolog of; RAD51OMIM
3(#614508, phenotype) Mirror movements 2; MRMV2OMIM


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2014-2019 (C) Yonsei Proteome Research Center