Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q06787)
Protein (NX_Q06787)
Protein
Gene SymbolFMR1 to neXtProt (NX_Q06787)
DescriptionFragile X mental retardation protein 1
ChromosomeX
LocationXq27.3 (146993469 ~ 147032645) to Ensembl
Sequene Features : Isoforms 9, Variants 94, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mRNA transport
.negative regulation of translational initiation
.negative regulation of translation
.central nervous system development
.poly(A) RNA binding
.mRNA binding
.RNA binding
.neuronal ribonucleoprotein granule
.synapse
.cell body
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
9 94 8
2014-09-19protein level
9 73 8
2014-05-27protein level
8 73 8
2014-02-25protein level
8 72 5
2013-12-09protein level
8 66 5
2013-11-01protein level
8 64 5
2013-09-12protein level
8 64 4
2013-08-17protein level
8 64 4
2013-07-15protein level
8 31 3
2013-06-11protein level
8 31 3
2013-02-12protein level
8 11 19
2012-12-20protein level
8 11 19
2012-10-30protein level
8 13 19
2012-10-07protein level
8 13 3
2012-08-24protein level
8 13 3
2012-07-28protein level
8 13 3
2012-06-08protein level
8 9 3
2012-05-07protein level
8 9 3
2012-04-10protein level
8 9 3
2012-01-13protein level
8 9 3
2011-12-20protein level
8 11 3
2011-11-11protein level
8 11 2
2011-08-23protein level
8 11 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q06787-1
0 28 3 71130.661
NX_Q06787-2
0 26 3 66929.4668
NX_Q06787-3
0 28 3 69982.2059
NX_Q06787-4
0 27 3 67988.2003
NX_Q06787-5
0 27 3 68412.5405
NX_Q06787-6
0 26 3 66418.5349
NX_Q06787-7
0 27 3 69136.6554
NX_Q06787-8
0 26 3 66205.3519
NX_Q06787-9
0 27 3 68923.4724
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10224470,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-10224470,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
3 EBI-366305,EBI-1048143 CYFIP1  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.cognition
.axon extension
  + 8 more...
.actin filament binding
.Rac GTPase binding
.protein complex binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 7 more...
4 EBI-366305,EBI-2433893 CYFIP2  
  .activation of cysteine-type endopeptidase activity
.vascular endothelial growth factor receptor signaling pathway
.positive regulation of proteolysis
  + 5 more...
.N/A .extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites50
bladder33
blood49
brain25
cervix41
connective tissue6
ear62
embryonic tissue65
eye14
intestine43
kidney109
liver29
lung32
lymph node133
mammary gland33
mouth15
muscle28
ovary39
pancreas23
placenta60
prostate36
skin18
spleen56
stomach20
testis13
thymus37
thyroid21
trachea19
uterus99
Health State
TissuesTPM*
normal42
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor33
germ cell tumor49
head and neck tumor14
kidney tumor14
leukemia52
liver tumor10
lung tumor38
lymphoma13
non-neoplasia62
ovarian tumor26
pancreatic tumor9
prostate cancer67
skin tumor23
soft tissue/muscle tissue tumor47
uterine tumor88
Developmental Stage
TissuesTPM*
adult39
embryoid body128
fetus25
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.6
adrenal gland18.3
appendix28.6
bone marrow31
cerebral cortex31.6
colon19.9
duodenum21.3
esophagus17.5
gallbladder19.8
heart muscle19.8
kidney32.2
liver25.2
lung22.3
lymph node27.3
ovary31.1
pancreas7.3
placenta38.6
prostate17.2
salivary gland12.8
skin21
small intestine21.3
spleen30.5
stomach18.5
testis22.4
thyroid gland32.9
urinary bladder21.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#300623, phenotype) Fragile x tremor/ataxia syndrome; FXTASOMIM
2(#300624, phenotype) Fragile x mental retardation syndromeOMIM
3(*309550, gene) Fmr1 gene; FMR1OMIM
4(#311360, phenotype) Premature ovarian failure 1; POF1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center