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> Protein (NX_Q07002)
Protein (NX_Q07002)
Protein
Gene SymbolCDK18 to neXtProt (NX_Q07002)
DescriptionCyclin-dependent kinase 18
Chromosome1
Location1q32.1 (205473723 ~ 205501921) to Ensembl
Sequene Features : Isoforms 3, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 64 9
2014-09-19protein level
3 46 9
2014-05-27protein level
3 46 9
2014-02-25protein level
3 45 8
2013-12-09protein level
3 32 8
2013-11-01protein level
3 30 7
2013-09-12protein level
3 30 7
2013-08-17protein level
3 30 7
2013-07-15protein level
3 20 7
2013-06-11protein level
3 20 7
2013-02-12protein level
3 12 36
2012-12-20protein level
3 13 36
2012-10-30protein level
3 15 36
2012-10-07protein level
3 15 12
2012-08-24protein level
3 15 12
2012-07-28protein level
3 15 12
2012-06-08protein level
3 19 12
2012-05-07protein level
3 16 12
2012-04-10protein level
3 16 12
2012-01-13protein level
3 12 12
2011-12-20protein level
3 12 12
2011-11-11protein level
3 12 12
2011-08-23protein level
3 12 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q07002-1
0 22 4 54145.7329
NX_Q07002-2
0 22 4 54389.8568
NX_Q07002-3
2 21 4 57540.5317
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746238,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
2 EBI-746238,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-746238,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
4 EBI-746238,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-746238,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
6 EBI-746238,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
7 EBI-746238,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
8 EBI-746238,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
9 EBI-746238,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
10 EBI-746238,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
11 EBI-746238,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
12 EBI-746238,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
13 EBI-746238,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder167
bone13
brain169
connective tissue13
embryonic tissue37
esophagus49
eye105
heart67
intestine73
kidney52
larynx85
liver4
lung35
lymph22
lymph node22
mammary gland6
mouth60
nerve64
ovary98
pancreas28
placenta42
prostate36
skin23
spleen18
testis34
thymus75
thyroid42
trachea19
uterus47
Health State
TissuesTPM*
normal74
bladder carcinoma227
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor71
esophageal tumor57
gastrointestinal tumor16
germ cell tumor41
glioma121
head and neck tumor52
kidney tumor87
lung tumor48
lymphoma41
non-neoplasia31
ovarian tumor118
pancreatic tumor19
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma150
skin tumor39
uterine tumor99
Developmental Stage
TissuesTPM*
adult53
embryoid body42
blastocyst65
fetus28
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.7
adrenal gland7.5
appendix5.9
bone marrow1
cerebral cortex53.2
colon11.9
duodenum36.2
esophagus4.8
gallbladder14.6
heart muscle79
kidney32.5
liver6.2
lung14.4
lymph node4.2
ovary13.8
pancreas9.5
placenta21.5
prostate7.8
salivary gland26.3
skin4.1
small intestine25.6
spleen9.8
stomach13.3
testis3.6
thyroid gland9.6
urinary bladder8.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*169190, gene) Pctaire protein kinase 3; PCTK3OMIM


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