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> Protein (NX_Q07666)
Protein (NX_Q07666)
Protein
Gene SymbolKHDRBS1 to neXtProt (NX_Q07666)
DescriptionKH domain-containing, RNA-binding, signal transduction-associated protein 1
Chromosome1
Location1p35.1 (32479430 ~ 32526451) to Ensembl
Sequene Features : Isoforms 3, Variants 37, PTMs 35 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 37 35
2014-09-19protein level
3 25 34
2014-05-27protein level
3 25 36
2014-02-25protein level
3 25 32
2013-12-09protein level
3 22 32
2013-11-01protein level
3 21 29
2013-09-12protein level
3 21 29
2013-08-17protein level
3 21 29
2013-07-15protein level
3 12 27
2013-06-11protein level
3 12 27
2013-02-12protein level
3 2 73
2012-12-20protein level
3 2 73
2012-10-30protein level
3 3 73
2012-10-07protein level
3 3 26
2012-08-24protein level
3 3 26
2012-07-28protein level
3 3 26
2012-06-08protein level
3 6 26
2012-05-07protein level
3 4 26
2012-04-10protein level
3 4 26
2012-01-13protein level
3 7 26
2011-12-20protein level
3 7 26
2011-11-11protein level
3 4 21
2011-08-23protein level
3 4 21
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q07666-1
0 11 2 48197.0453
NX_Q07666-2
1 10 2 45831.8303
NX_Q07666-3
0 10 1 43999.7371
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1364,EBI-2795384 ZBTB7A  
  .negative regulation of transcription, DNA-templated
.cell differentiation
.multicellular organismal development
  + 2 more...
.metal ion binding
.histone acetyltransferase binding
.DNA binding
.nucleus
2 EBI-1364,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
3 EBI-1364,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
4 EBI-1364,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
5 EBI-1364,EBI-352662 HNRNPA1  
  .nuclear import
.nuclear export
.mRNA transport
  + 7 more...
.poly(A) RNA binding
.single-stranded RNA binding
.RNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.intermediate filament cytoskeleton
  + 5 more...
6 EBI-1364,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
7 EBI-1364,EBI-625518 VAV1  
  .apoptotic signaling pathway
.reactive oxygen species metabolic process
.regulation of small GTPase mediated signal transduction
  + 19 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.sequence-specific DNA binding transcription factor activity
.cell-cell junction
.plasma membrane
.cytosol
8 EBI-1364,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
9 EBI-1364,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
10 EBI-1364,EBI-679562 SMARCA2  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 9 more...
.transcription regulatory region DNA binding
.DNA-dependent ATPase activity
.ATP binding
  + 3 more...
.nBAF complex
.npBAF complex
.intermediate filament cytoskeleton
  + 5 more...
11 EBI-1364,EBI-518246 JAK3  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of dendritic cell apoptotic process
.response to interleukin-9
  + 30 more...
.hormone receptor binding
.protein phosphatase binding
.ATP binding
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.endomembrane system
.cytoskeleton
.cytosol
12 EBI-1364,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland91
ascites50
bladder167
blood139
bone335
bone marrow164
brain115
cervix41
connective tissue107
ear62
embryonic tissue206
eye148
heart245
intestine90
kidney118
liver97
lung146
lymph67
lymph node100
mammary gland59
mouth45
muscle65
nerve64
ovary108
pancreas117
parathyroid48
pituitary gland121
placenta137
prostate84
salivary gland246
skin90
spleen37
stomach83
testis151
thymus112
thyroid64
trachea57
umbilical cord72
uterus198
vascular77
Health State
TissuesTPM*
normal113
adrenal tumor79
breast (mammary gland) tumor75
chondrosarcoma229
colorectal tumor79
gastrointestinal tumor75
germ cell tumor197
glioma158
head and neck tumor44
kidney tumor116
leukemia158
liver tumor177
lung tumor126
lymphoma124
non-neoplasia51
ovarian tumor118
pancreatic tumor38
primitive neuroectodermal tumor of the CNS204
prostate cancer38
retinoblastoma215
skin tumor87
soft tissue/muscle tissue tumor191
uterine tumor133
Developmental Stage
TissuesTPM*
adult112
embryoid body200
blastocyst195
neonate32
fetus183
infant170
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue51.3
adrenal gland49.7
appendix70.7
bone marrow59.9
cerebral cortex43.2
colon63.5
duodenum54.2
esophagus59.8
gallbladder59.9
heart muscle45.1
kidney51.3
liver30.6
lung54.1
lymph node92.2
ovary105
pancreas24.5
placenta62.9
prostate54.8
salivary gland33.9
skin50.3
small intestine54.9
spleen59.7
stomach49
testis53.4
thyroid gland65.6
urinary bladder67.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602489, gene) Kh domain-containing, rna-binding, signal transduction-associatedOMIM


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