Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q07812)
Protein (NX_Q07812)
Protein
Gene SymbolBAX to neXtProt (NX_Q07812)
DescriptionApoptosis regulator BAX
Chromosome19
Location19q13.33 (49458072 ~ 49465055) to Ensembl
Sequene Features : Isoforms 8, Variants 32, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 32 2
2014-09-19protein level
8 29 2
2014-05-27protein level
8 28 2
2014-02-25protein level
8 28 2
2013-12-09protein level
8 24 2
2013-11-01protein level
8 24 1
2013-09-12protein level
8 24 1
2013-08-17protein level
8 24 1
2013-07-15protein level
8 20 0
2013-06-11protein level
8 20 0
2013-02-12protein level
8 14 6
2012-12-20protein level
8 14 6
2012-10-30protein level
8 15 6
2012-10-07protein level
8 15 1
2012-08-24protein level
8 14 1
2012-07-28protein level
8 14 1
2012-06-08protein level
8 19 1
2012-05-07protein level
8 16 1
2012-04-10protein level
8 16 1
2012-01-13protein level
8 12 1
2011-12-20protein level
8 12 1
2011-11-11protein level
8 12 1
2011-08-23protein level
8 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q07812-1
0 10 0 21170.7019
NX_Q07812-2
5 9 0 24204.3255
NX_Q07812-3
2 1 0 4675.2221
NX_Q07812-4
1 6 0 15762.0259
NX_Q07812-5
2 8 1 18117.0345
NX_Q07812-6
0 5 0 12878.6486
NX_Q07812-7
0 8 0 19299.8955
NX_Q07812-8
1 9 0 19705.0179
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-516580,EBI-526406 BCL2L11  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of fibroblast apoptotic process
.positive regulation of IRE1-mediated unfolded protein response
  + 42 more...
.N/A .BIM-BCL-2 complex
.BIM-BCL-xl complex
.extrinsic component of membrane
  + 3 more...
2 EBI-516580,EBI-371750 ERN1  
  .peptidyl-serine trans-autophosphorylation
.insulin metabolic process
.positive regulation of endoplasmic reticulum unfolded protein response
  + 23 more...
.Hsp90 protein binding
.ADP binding
.protein homodimerization activity
  + 7 more...
.IRE1-RACK1-PP2A complex
.IRE1-TRAF2-ASK1 complex
.Ire1 complex
  + 6 more...
3 EBI-516580,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
4 EBI-516580,EBI-353208 XRCC6  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
5 EBI-516580,EBI-519672 BID  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
6 EBI-516580,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
7 EBI-516580,EBI-1003422 MCL1  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of response to DNA damage stimulus
  + 10 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
.protein channel activity
.Bcl-2 family protein complex
.integral component of membrane
.membrane
  + 7 more...
8 EBI-516580,EBI-519866 BAK1  
  .positive regulation of IRE1-mediated unfolded protein response
.apoptotic process involved in patterning of blood vessels
.positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  + 54 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
.identical protein binding
.pore complex
.integral component of mitochondrial outer membrane
.cytosol
  + 3 more...
9 EBI-516580,EBI-2129982 RNF144B  
  .protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.apoptotic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.cytoplasm
.ubiquitin ligase complex
10 EBI-516580,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
11 EBI-516580,EBI-2952704 UVRAG  
  .double-strand break repair via classical nonhomologous end joining
.regulation of protein serine/threonine kinase activity
.regulation of vesicle-mediated transport
  + 10 more...
.SNARE binding .phagocytic vesicle
.protein complex
.midbody
  + 6 more...
12 EBI-516580,EBI-751215 PYCARD  
  .regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of interleukin-10 secretion
  + 51 more...
.BMP receptor binding
.protein homodimerization activity
.Pyrin domain binding
  + 6 more...
.AIM2 inflammasome complex
.NLRP3 inflammasome complex
.NLRP1 inflammasome complex
  + 9 more...
13 EBI-516580,EBI-5291808 SH3GLB1  
  .positive regulation of autophagic vacuole assembly
.positive regulation of protein targeting to mitochondrion
.protein localization to vacuolar membrane
  + 11 more...
.protein homodimerization activity
.identical protein binding
.lipid binding
.extracellular exosome
.midbody
.mitochondrial outer membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood16
bone13
bone marrow20
brain4
connective tissue13
embryonic tissue46
eye33
intestine17
liver9
lung23
lymph45
mammary gland6
mouth60
nerve64
ovary9
pancreas18
parathyroid48
pharynx908
placenta24
prostate5
salivary gland49
skin9
stomach20
testis6
thymus25
uterus12
Health State
TissuesTPM*
normal14
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor8
germ cell tumor7
glioma9
head and neck tumor313
leukemia10
liver tumor20
lung tumor58
lymphoma27
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult34
embryoid body71
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.7
adrenal gland35.5
appendix77.1
bone marrow44.6
cerebral cortex29.5
colon80.9
duodenum84.1
esophagus31.5
gallbladder48.6
heart muscle16.7
kidney38.5
liver27.3
lung51.6
lymph node69.5
ovary19.5
pancreas12.4
placenta49.8
prostate44.6
salivary gland14.7
skin23.5
small intestine85.9
spleen77
stomach71.4
testis23.9
thyroid gland25.9
urinary bladder45.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600040, gene) Bcl2-associated x protein; BAXOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center