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> Protein (NX_Q07817)
Protein (NX_Q07817)
Protein
Gene SymbolBCL2L1 to neXtProt (NX_Q07817)
DescriptionBcl-2-like protein 1
Chromosome20
Location20q11.21 (30252255 ~ 30311792) to Ensembl
Sequene Features : Isoforms 3, Variants 21, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 21 4
2014-09-19protein level
3 19 4
2014-05-27protein level
3 19 4
2014-02-25protein level
3 20 4
2013-12-09protein level
3 16 4
2013-11-01protein level
3 15 3
2013-09-12protein level
3 15 3
2013-08-17protein level
3 15 3
2013-07-15protein level
3 8 2
2013-06-11protein level
3 8 2
2013-02-12protein level
3 5 6
2012-12-20protein level
3 5 6
2012-10-30protein level
3 6 6
2012-10-07protein level
3 6 2
2012-08-24protein level
3 2 2
2012-07-28protein level
3 2 2
2012-06-08protein level
3 13 2
2012-05-07protein level
3 13 2
2012-04-10protein level
3 13 2
2012-01-13protein level
3 13 2
2011-12-20protein level
3 13 2
2011-11-11protein level
3 12 1
2011-08-23protein level
3 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q07817-1
1 9 0 26032.6297
NX_Q07817-2
1 6 0 18882.1344
NX_Q07817-3
3 8 0 25274.3549
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-287195,EBI-701322 HRK  
  .positive regulation of release of cytochrome c from mitochondria
.positive regulation of apoptotic process
.positive regulation of protein homooligomerization
.apoptotic process
.N/A .integral component of membrane
.mitochondrion
2 EBI-287195,EBI-520756 SIVA1  
  .positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 3 more...
.metal ion binding
.zinc ion binding
.CD27 receptor binding
.virus receptor activity
.mitochondrion
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-287195,EBI-526406 BCL2L11  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of fibroblast apoptotic process
.positive regulation of IRE1-mediated unfolded protein response
  + 42 more...
.N/A .BIM-BCL-2 complex
.BIM-BCL-xl complex
.extrinsic component of membrane
  + 3 more...
4 EBI-287195,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
5 EBI-287195,EBI-4322678 CLU  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of neurofibrillary tangle assembly
  + 34 more...
.misfolded protein binding
.chaperone binding
.ubiquitin protein ligase binding
.apical dendrite
.neurofibrillary tangle
.blood microparticle
  + 15 more...
6 EBI-287195,EBI-519672 BID  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
7 EBI-78035,EBI-446479 CYCS  
  .intrinsic apoptotic signaling pathway
.cellular respiration
.small molecule metabolic process
  + 14 more...
.electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
.heme binding
.iron ion binding
.respiratory chain
.cytosol
.mitochondrial intermembrane space
  + 4 more...
8 EBI-287195,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
9 EBI-287195,EBI-700794 BIK  
  .positive regulation of release of cytochrome c from mitochondria
.positive regulation of protein homooligomerization
.apoptotic mitochondrial changes
  + 3 more...
.N/A .mitochondrial membrane
.integral component of membrane
.endomembrane system
10 EBI-287195,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
11 EBI-287195,EBI-949378 BECN1  
  .positive regulation of mitochondrion degradation
.positive regulation of attachment of mitotic spindle microtubules to kinetochore
.activation of mitophagy in response to mitochondrial depolarization
  + 28 more...
.phosphatidylinositol 3-kinase binding .phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 12 more...
12 EBI-287195,EBI-519866 BAK1  
  .positive regulation of IRE1-mediated unfolded protein response
.apoptotic process involved in patterning of blood vessels
.positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  + 54 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
.identical protein binding
.pore complex
.integral component of mitochondrial outer membrane
.cytosol
  + 3 more...
13 EBI-287195,EBI-1207633 VRK2  
  .regulation of interleukin-1-mediated signaling pathway
.protein autophosphorylation
.regulation of MAPK cascade
  + 7 more...
.protein domain specific binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.protein complex
.mitochondrial membrane
.integral component of membrane
  + 4 more...
14 EBI-78035,EBI-700771 BAD  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of type B pancreatic cell development
.positive regulation of neuron death
  + 58 more...
.protein kinase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.lipid binding
.phospholipid binding
.cytosol
.mitochondrial outer membrane
.mitochondrion
15 EBI-78035,EBI-3919268 BMF  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of apoptotic signaling pathway
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 6 more...
.N/A .myosin complex
.plasma membrane
.cytosol
  + 2 more...
16 EBI-287195,EBI-519884 BBC3  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of cysteine-type endopeptidase activity
.positive regulation of IRE1-mediated unfolded protein response
  + 21 more...
.N/A .cytosol
.mitochondrial outer membrane
.mitochondrion
17 EBI-78035,EBI-1220518 NLRP1  
  .neuron apoptotic process
.regulation of inflammatory response
.positive regulation of interleukin-1 beta secretion
  + 6 more...
.protein domain specific binding
.enzyme binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.ATP binding
.NLRP1 inflammasome complex
.cytosol
.nucleus
.intracellular
18 EBI-78035,EBI-1386527 SPNS1  
  .transmembrane transport
.locomotion
.sphingosine-1-phosphate signaling pathway
.sphingolipid transporter activity .vesicle
.integral component of membrane
.lysosomal membrane
.mitochondrial inner membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder33
blood57
bone41
brain57
cervix61
connective tissue13
embryonic tissue37
esophagus49
eye119
heart55
intestine133
kidney109
liver224
lung125
lymph node100
mammary gland46
mouth15
muscle75
ovary216
pancreas103
pituitary gland60
placenta102
prostate68
salivary gland197
skin66
spleen56
stomach219
testis43
thyroid214
tonsil117
uterus120
vascular58
Health State
TissuesTPM*
normal45
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma96
colorectal tumor266
esophageal tumor57
gastrointestinal tumor151
germ cell tumor125
glioma83
head and neck tumor112
kidney tumor246
leukemia31
liver tumor468
lung tumor311
non-neoplasia31
ovarian tumor105
pancreatic tumor209
primitive neuroectodermal tumor of the CNS55
prostate cancer67
retinoblastoma150
skin tumor103
soft tissue/muscle tissue tumor111
uterine tumor188
Developmental Stage
TissuesTPM*
adult63
embryoid body42
blastocyst65
fetus34
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue43.4
adrenal gland32.2
appendix29
bone marrow71.4
cerebral cortex41
colon41.3
duodenum45.4
esophagus60.1
gallbladder67.6
heart muscle38.3
kidney70.6
liver40.6
lung54.3
lymph node30.3
ovary18.5
pancreas24.6
placenta44.6
prostate40.4
salivary gland27.5
skin27.1
small intestine41
spleen39.1
stomach45.6
testis43.5
thyroid gland44
urinary bladder46.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600039, gene) Bcl2-like 1; BCL2L1OMIM


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2014-2019 (C) Yonsei Proteome Research Center