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> Protein (NX_Q07869)
Protein (NX_Q07869)
Protein
Gene SymbolPPARA to neXtProt (NX_Q07869)
DescriptionPeroxisome proliferator-activated receptor alpha
Chromosome22
Location22q13.31 (46546424 ~ 46639653) to Ensembl
Sequene Features : Isoforms 2, Variants 61, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription regulatory region DNA binding
.negative regulation of neuron death
.regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
  + 35 more...
.sequence-specific DNA binding
.ubiquitin conjugating enzyme binding
.lipid binding
  + 11 more...
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 61 0
2014-09-19protein level
2 39 0
2014-05-27protein level
2 39 0
2014-02-25protein level
2 38 0
2013-12-09protein level
2 30 0
2013-11-01protein level
2 30 0
2013-09-12protein level
2 30 0
2013-08-17protein level
2 30 0
2013-07-15protein level
1 23 0
2013-06-11protein level
1 23 0
2013-02-12protein level
1 17 0
2012-12-20protein level
1 17 0
2012-10-30protein level
1 20 0
2012-10-07protein level
1 20 0
2012-08-24protein level
1 19 0
2012-07-28protein level
1 19 0
2012-06-08protein level
1 30 0
2012-05-07protein level
1 25 0
2012-04-10protein level
1 25 0
2012-01-13protein level
1 21 0
2011-12-20protein level
1 21 0
2011-11-11protein level
1 21 0
2011-08-23protein level
1 21 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q07869-1
14 2 0 52190.8729
NX_Q07869-2
1 2 0 18929.7825
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-78615,EBI-347233 NCOR1  
  .regulation of fatty acid transport
.regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
.regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
  + 22 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.histone deacetylase binding
  + 6 more...
.transcriptional repressor complex
.membrane
.spindle microtubule
  + 5 more...
2 EBI-78615,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-78615,EBI-960730 CHD9  
  .small molecule metabolic process
.cellular lipid metabolic process
.chromatin modification
  + 2 more...
.ATP binding
.helicase activity
.DNA binding
.plasma membrane
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
bladder33
blood8
bone41
bone marrow20
brain19
connective tissue20
embryonic tissue9
eye23
heart33
intestine64
kidney66
liver73
lung32
lymph node11
mammary gland6
mouth30
muscle178
nerve64
ovary9
pancreas9
parathyroid48
pharynx49
placenta24
skin28
spleen18
stomach20
testis2
thyroid42
uterus17
vascular19
Health State
TissuesTPM*
normal33
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma60
colorectal tumor53
gastrointestinal tumor25
germ cell tumor15
glioma74
head and neck tumor22
kidney tumor58
leukemia10
liver tumor62
lung tumor19
non-neoplasia51
ovarian tumor13
pancreatic tumor19
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor119
uterine tumor11
Developmental Stage
TissuesTPM*
adult36
embryoid body28
fetus5
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.8
adrenal gland8.7
appendix6
bone marrow3.1
cerebral cortex5.2
colon14.9
duodenum18.9
esophagus8
gallbladder6.5
heart muscle24.8
kidney32.3
liver18.2
lung4.3
lymph node4.6
ovary12.8
pancreas4.6
placenta4.7
prostate7.1
salivary gland6.7
skin7.5
small intestine21.6
spleen5.5
stomach6.2
testis2.6
thyroid gland9
urinary bladder7.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(+170998, gene/phenotype) Peroxisome proliferator-activated receptor-alpha; PPARAOMIM


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