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> Protein (NX_Q07889)
Protein (NX_Q07889)
Protein
Gene SymbolSOS1 to neXtProt (NX_Q07889)
DescriptionSon of sevenless homolog 1
Chromosome2
Location2p22.1 (39208537 ~ 39351486) to Ensembl
Sequene Features : Isoforms 2, Variants 187, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 187 10
2014-09-19protein level
1 159 10
2014-05-27protein level
1 159 10
2014-02-25protein level
1 159 10
2013-12-09protein level
1 145 10
2013-11-01protein level
1 139 10
2013-09-12protein level
1 139 10
2013-08-17protein level
1 139 10
2013-07-15protein level
1 121 10
2013-06-11protein level
1 121 10
2013-02-12protein level
1 80 6
2012-12-20protein level
1 80 6
2012-10-30protein level
1 82 6
2012-10-07protein level
1 82 6
2012-08-24protein level
1 62 6
2012-07-28protein level
1 62 6
2012-06-08protein level
1 62 6
2012-05-07protein level
1 62 6
2012-04-10protein level
1 62 6
2012-01-13protein level
1 57 6
2011-12-20protein level
1 57 6
2011-11-11protein level
1 57 6
2011-08-23protein level
1 29 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q07889-1
41 13 10 152367.6916
NX_Q07889-2
2 13 1 36050.5184
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297487,EBI-350145 HRAS  
  .positive regulation of miRNA metabolic process
.positive regulation of actin cytoskeleton reorganization
.positive regulation of ruffle assembly
  + 53 more...
.protein C-terminus binding
.GTP binding
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 4 more...
2 EBI-297487,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
3 EBI-297487,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
4 EBI-297487,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
5 EBI-297487,EBI-1049657 NEB  
  .regulation of actin filament length
.muscle filament sliding
.somatic muscle development
.muscle organ development
.structural constituent of muscle .extracellular exosome
.Z disc
.actin cytoskeleton
.cytosol
6 EBI-297487,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
7 EBI-297487,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
8 EBI-297487,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
9 EBI-297487,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
10 EBI-297487,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
11 EBI-297487,EBI-7014859 SH3PXD2A  
  .osteoclast fusion
.superoxide metabolic process
.phosphatidylinositol binding .cell projection
.cell junction
.cytoplasm
.podosome
12 EBI-297487,EBI-77926 PACSIN3  
  .membrane tubulation
.negative regulation of calcium ion transport
.positive regulation of membrane protein ectodomain proteolysis
  + 4 more...
.calcium channel inhibitor activity
.lipid binding
.cytoskeletal protein binding
.phospholipid binding
.extracellular exosome
.membrane-bounded vesicle
.membrane
  + 4 more...
13 EBI-297487,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood24
bone41
bone marrow41
brain38
cervix123
connective tissue20
embryonic tissue42
eye43
heart78
intestine4
kidney52
liver19
lung2
lymph node133
mammary gland6
mouth45
muscle9
nerve64
ovary19
pancreas18
parathyroid48
placenta3
prostate42
skin33
spleen18
stomach10
testis43
thymus12
thyroid85
tonsil58
trachea19
uterus21
vascular19
Health State
TissuesTPM*
normal1
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor115
chondrosarcoma72
colorectal tumor53
gastrointestinal tumor8
germ cell tumor30
glioma27
head and neck tumor37
kidney tumor58
leukemia31
liver tumor20
lymphoma13
non-neoplasia20
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
uterine tumor22
Developmental Stage
TissuesTPM*
adult2
embryoid body57
blastocyst65
fetus80
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.5
adrenal gland9.6
appendix17.3
bone marrow5.4
cerebral cortex12.2
colon13.9
duodenum14.2
esophagus13
gallbladder17.4
heart muscle7.8
kidney10.7
liver6.4
lung11.7
lymph node18.7
ovary22.6
pancreas4.2
placenta14.4
prostate13
salivary gland8.1
skin9.4
small intestine15.9
spleen15.2
stomach11.9
testis16.6
thyroid gland18.4
urinary bladder20.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#135300, phenotype) Fibromatosis, gingival, 1; GINGF1OMIM
2(*182530, gene) Son of sevenless, drosophila, homolog 1; SOS1OMIM
3(#610733, phenotype) Noonan syndrome 4; NS4OMIM


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