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> Protein (NX_Q07890)
Protein (NX_Q07890)
Protein
Gene SymbolSOS2 to neXtProt (NX_Q07890)
DescriptionSon of sevenless homolog 2
Chromosome14
Location14q21.3 (50583847 ~ 50698276) to Ensembl
Sequene Features : Isoforms 2, Variants 143, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity
.DNA binding
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 143 1
2014-09-19protein level
2 109 1
2014-05-27protein level
2 109 1
2014-02-25protein level
1 107 1
2013-12-09protein level
1 86 1
2013-11-01protein level
1 82 1
2013-09-12protein level
1 82 1
2013-08-17protein level
1 82 1
2013-07-15protein level
1 54 1
2013-06-11protein level
1 54 1
2013-02-12protein level
1 25 0
2012-12-20protein level
1 25 0
2012-10-30protein level
1 30 0
2012-10-07protein level
1 30 0
2012-08-24protein level
1 20 0
2012-07-28protein level
1 20 0
2012-06-08protein level
1 37 0
2012-05-07protein level
1 37 0
2012-04-10protein level
1 37 0
2012-01-13protein level
1 31 0
2011-12-20protein level
1 31 0
2011-11-11protein level
1 31 0
2011-08-23protein level
1 31 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q07890-1
2 54 10 152882.0111
NX_Q07890-2
1 54 10 148907.933
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-298181,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
2 EBI-298181,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-298181,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
4 EBI-298181,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
5 EBI-298181,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
6 EBI-298181,EBI-77926 PACSIN3  
  .membrane tubulation
.negative regulation of calcium ion transport
.positive regulation of membrane protein ectodomain proteolysis
  + 4 more...
.calcium channel inhibitor activity
.lipid binding
.cytoskeletal protein binding
.phospholipid binding
.extracellular exosome
.membrane-bounded vesicle
.membrane
  + 4 more...
7 EBI-298181,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder100
blood24
bone41
bone marrow102
brain23
cervix20
connective tissue6
ear62
embryonic tissue18
eye9
heart44
intestine12
kidney75
larynx85
liver38
lung23
lymph node133
mammary gland39
mouth75
muscle37
nerve128
ovary19
pancreas18
parathyroid97
placenta98
prostate36
salivary gland49
skin28
stomach20
testis41
thymus12
thyroid64
uterus17
Health State
TissuesTPM*
normal41
bladder carcinoma56
cervical tumor28
chondrosarcoma36
colorectal tumor17
gastrointestinal tumor16
germ cell tumor26
glioma9
head and neck tumor59
kidney tumor72
leukemia105
lung tumor9
non-neoplasia82
ovarian tumor26
pancreatic tumor9
prostate cancer19
skin tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult43
embryoid body42
fetus43
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.4
adrenal gland15.6
appendix16.8
bone marrow24.2
cerebral cortex14.2
colon17.4
duodenum19.6
esophagus17.6
gallbladder14.1
heart muscle17.1
kidney20.9
liver5.8
lung14.9
lymph node14.5
ovary14.6
pancreas7.7
placenta18.3
prostate14.5
salivary gland10.8
skin14.8
small intestine22.8
spleen15.4
stomach11.7
testis32.9
thyroid gland27.1
urinary bladder18.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601247, gene) Son of sevenless, drosophila, homolog 2; SOS2OMIM


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