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> Protein (NX_Q08117)
Protein (NX_Q08117)
Protein
Gene SymbolAES to neXtProt (NX_Q08117)
DescriptionAmino-terminal enhancer of split
Chromosome19
Location19p13.3 (3052908 ~ 3063105) to Ensembl
Sequene Features : Isoforms 2, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 15 5
2014-09-19protein level
2 11 5
2014-05-27protein level
2 11 5
2014-02-25protein level
2 11 5
2013-12-09protein level
2 11 5
2013-11-01protein level
2 11 5
2013-09-12protein level
2 11 5
2013-08-17protein level
2 11 5
2013-07-15protein level
2 10 1
2013-06-11protein level
2 10 1
2013-02-12protein level
2 2 2
2012-12-20protein level
2 2 2
2012-10-30protein level
2 2 2
2012-10-07protein level
2 2 1
2012-08-24protein level
2 2 1
2012-07-28protein level
2 2 1
2012-06-08protein level
2 3 1
2012-05-07protein level
2 3 1
2012-04-10protein level
1 3 1
2012-01-13protein level
1 7 1
2011-12-20protein level
1 7 1
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q08117-1
1 6 1 21955.9332
NX_Q08117-2
4 6 1 29072.7384
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717810,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-717810,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
3 EBI-717810,EBI-308663 ARHGAP32  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.phosphatidylinositol binding
.GTPase activator activity
.postsynaptic membrane
.dendritic spine
.cell junction
  + 7 more...
4 EBI-717810,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
5 EBI-717810,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
6 EBI-717810,EBI-3452216 TBX3  
  .positive regulation of stem cell proliferation
.cellular senescence
.sinoatrial node cell development
  + 35 more...
.sequence-specific DNA binding
.RNA polymerase II activating transcription factor binding
.RNA polymerase II transcription factor binding
  + 2 more...
.nucleus
7 EBI-717810,EBI-1050253 CTAGE5  
  .positive regulation of catalytic activity .enzyme activator activity .membrane
8 EBI-717810,EBI-983612 FOXP2  
  .positive regulation of epithelial cell proliferation involved in lung morphogenesis
.righting reflex
.smooth muscle tissue development
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 4 more...
.nucleus
9 EBI-717810,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
10 EBI-717810,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
11 EBI-717810,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
12 EBI-717810,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
13 EBI-717810,EBI-9027467 PROP1  
  .somatotropin secreting cell differentiation
.canonical Wnt signaling pathway
.hypophysis morphogenesis
  + 8 more...
.sequence-specific DNA binding
.chromatin binding
.transcription factor complex
.nucleus
14 EBI-717810,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
15 EBI-717810,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
16 EBI-717810,EBI-739806 CCNK  
  .positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
.negative regulation of cell cycle arrest
.cell division
  + 8 more...
.protein kinase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.cyclin-dependent protein serine/threonine kinase activity
.nucleus
.cyclin K-CDK13 complex
.cyclin K-CDK12 complex
17 EBI-717810,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
18 EBI-717810,EBI-2902468 SKIL  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.response to growth factor
  + 19 more...
.SMAD binding
.protein complex binding
.protein domain specific binding
  + 4 more...
.protein complex
.PML body
.cytoplasm
  + 3 more...
19 EBI-717810,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
20 EBI-717810,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
21 EBI-717810,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
22 EBI-717810,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
23 EBI-717810,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
24 EBI-717810,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
25 EBI-717810,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
26 EBI-717810,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
27 EBI-717810,EBI-3505701 SOX5  
  .positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
28 EBI-717810,EBI-765407 BCL6  
  .negative regulation of cellular senescence
.positive regulation of cellular component movement
.regulation of immune response
  + 32 more...
.metal ion binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 4 more...
.nucleus
29 EBI-717810,EBI-347462 QARS  
  .gene expression
.brain development
.glutaminyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.glutamine-tRNA ligase activity
.cytosol
.mitochondrial matrix
.cytoplasm
30 EBI-717810,EBI-352986 HNRNPF  
  .regulation of RNA splicing
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.single-stranded RNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
31 EBI-717810,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
32 EBI-717810,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
33 EBI-717810,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
34 EBI-717810,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
35 EBI-717810,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
36 EBI-717810,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
37 EBI-717810,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
38 EBI-717810,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
39 EBI-717810,EBI-2803328 PRR3  
  .N/A .metal ion binding
.poly(A) RNA binding
.N/A
40 EBI-717810,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
41 EBI-717810,EBI-721525 RBM10  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding
.identical protein binding
.protein complex binding
  + 2 more...
.nucleoplasm
.nucleus
42 EBI-717810,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
43 EBI-717810,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
44 EBI-717810,EBI-2341136 TRIM26  
  .negative regulation of viral release from host cell
.interferon-gamma-mediated signaling pathway
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 3 more...
.metal ion binding
.zinc ion binding
.DNA binding
.cytosol
45 EBI-717810,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
46 EBI-717810,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
47 EBI-717810,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
48 EBI-717810,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
49 EBI-717810,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
50 EBI-717810,EBI-10233719 DIP2A  
  .regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
51 EBI-717810,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
52 EBI-717810,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
53 EBI-717810,EBI-743675 SIX1  
  .regulation of skeletal muscle cell differentiation
.positive regulation of mesenchymal cell proliferation involved in ureter development
.negative regulation of branching involved in ureteric bud morphogenesis
  + 47 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 4 more...
.cytoplasm
.nucleolus
.transcription factor complex
  + 2 more...
54 EBI-717810,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
55 EBI-717810,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
56 EBI-717810,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
57 EBI-717810,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
58 EBI-717810,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
59 EBI-717810,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
60 EBI-717810,EBI-946029 C1orf94  
  .N/A .N/A .N/A
61 EBI-717810,EBI-10225049 OLIG3  
  .spinal cord motor neuron migration
.spinal cord motor neuron cell fate specification
.DNA binding
.RNA polymerase II transcription corepressor activity
.nucleus
62 EBI-717810,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
63 EBI-717810,EBI-744506 FAM124A  
  .N/A .N/A .N/A
64 EBI-717810,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
65 EBI-717810,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
66 EBI-717810,EBI-749051 C6orf165  
  .N/A .N/A .N/A
67 EBI-717810,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
68 EBI-717810,EBI-746909 CPSF7  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.membrane
.mRNA cleavage factor complex
.nucleoplasm
.nucleus
69 EBI-717810,EBI-747505 C1orf216  
  .N/A .N/A .N/A
70 EBI-717810,EBI-742750 BAHD1  
  .negative regulation of transcription, DNA-templated
.heterochromatin assembly
.transcription, DNA-templated
.chromatin silencing
.chromatin binding
.transcription regulatory region sequence-specific DNA binding
.chromatin silencing complex
.nucleoplasm
.chromatin
71 EBI-717810,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
72 EBI-717810,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
73 EBI-717810,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
74 EBI-717810,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
75 EBI-717810,EBI-739909 L3MBTL2  
  .chromatin modification
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.histone binding
.methylated histone binding
.zinc ion binding
.nucleus
76 EBI-717810,EBI-746778 MAGOHB  
  .mRNA transport
.RNA splicing
.mRNA processing
.poly(A) RNA binding .catalytic step 2 spliceosome
.exon-exon junction complex
77 EBI-717810,EBI-517623 BIRC7  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.regulation of natural killer cell apoptotic process
.negative regulation of apoptotic process
  + 4 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.enzyme binding
.ligase activity
  + 3 more...
.Golgi apparatus
.cytoplasm
.nucleus
78 EBI-717810,EBI-10225152 RNF31  
  .positive regulation of protein targeting to mitochondrion
.protein linear polyubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 4 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.LUBAC complex
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytoplasm
79 EBI-717810,EBI-10286106 LINC00526  
  .N/A .N/A .N/A
80 EBI-717810,EBI-710402 PPP1R16A  
  .N/A .protein phosphatase type 1 regulator activity .plasma membrane
81 EBI-717810,EBI-769261 EAF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .ELL-EAF complex
.nuclear speck
.Cajal body
  + 3 more...
82 EBI-717810,EBI-3918381 TSSK3  
  .intracellular signal transduction
.cell differentiation
.regulation of signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
83 EBI-717810,EBI-10292696 CIB3  
  .N/A .calcium ion binding .N/A
84 EBI-717810,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
85 EBI-717810,EBI-10297093 NUDT22  
  .N/A .hydrolase activity .nucleoplasm
86 EBI-717810,EBI-739773 CRACR2A  
  .positive regulation of calcium ion transport
.activation of store-operated calcium channel activity
.immune system process
.store-operated calcium entry
.calcium ion binding .membrane
.Golgi apparatus
.cytoplasm
  + 2 more...
87 EBI-717810,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
88 EBI-717810,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
89 EBI-717810,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
90 EBI-717810,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
91 EBI-717810,EBI-741626 FAM124B  
  .N/A .N/A .N/A
92 EBI-717810,EBI-3921014 ZNF576  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
93 EBI-717810,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
94 EBI-717810,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
95 EBI-717810,EBI-3921217 PARVG  
  .actin cytoskeleton reorganization
.cell-matrix adhesion
.actin binding .focal adhesion
.plasma membrane
.cytoskeleton
.cytoplasm
96 EBI-717810,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
97 EBI-717810,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
98 EBI-717810,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
99 EBI-717810,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
100 EBI-717810,EBI-1053490 NCDN  
  .regulation of neuronal synaptic plasticity
.bone resorption
.neuron projection development
.N/A .neuronal cell body
.dendrite
.membrane
.cytosol
101 EBI-717810,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
102 EBI-717810,EBI-741109 MLX  
  .negative regulation of transcription, DNA-templated
.small molecule metabolic process
.positive regulation of cellular metabolic process
  + 4 more...
.protein heterodimerization activity
.protein homodimerization activity
.transcription factor binding
  + 4 more...
.cytoplasm
.nucleus
103 EBI-717810,EBI-9057006 OSGIN1  
  .positive regulation of apoptotic process
.negative regulation of cell growth
.cell differentiation
.multicellular organismal development
.growth factor activity .N/A
104 EBI-717810,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
105 EBI-717810,EBI-347416 LSM2  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.Ral GTPase binding
.U6 snRNA binding
.catalytic step 2 spliceosome
.cytosol
.nucleoplasm
106 EBI-717810,EBI-1056751 PTRH2  
  .negative regulation of anoikis
.positive regulation of anoikis
.negative regulation of gene expression
  + 2 more...
.aminoacyl-tRNA hydrolase activity .membrane
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites225
bladder234
blood212
bone321
bone marrow61
brain150
cervix309
connective tissue100
embryonic tissue112
esophagus49
eye320
heart279
intestine159
kidney128
larynx213
liver63
lung268
lymph158
lymph node267
mammary gland165
mouth30
muscle272
nerve579
ovary226
pancreas271
parathyroid339
pharynx73
pituitary gland363
placenta173
prostate332
salivary gland296
skin223
spleen206
stomach219
testis50
thymus87
thyroid107
tonsil587
uterus168
vascular19
Health State
TissuesTPM*
normal166
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor182
cervical tumor231
chondrosarcoma265
colorectal tumor133
esophageal tumor57
gastrointestinal tumor185
germ cell tumor64
glioma354
head and neck tumor141
kidney tumor116
leukemia105
liver tumor62
lung tumor321
lymphoma235
non-neoplasia144
ovarian tumor262
pancreatic tumor476
primitive neuroectodermal tumor of the CNS251
prostate cancer308
retinoblastoma279
skin tumor231
soft tissue/muscle tissue tumor271
uterine tumor166
Developmental Stage
TissuesTPM*
adult222
embryoid body57
blastocyst146
fetus181
infant170
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue184.6
adrenal gland240
appendix166.3
bone marrow96
cerebral cortex195.8
colon182.7
duodenum116.4
esophagus140.2
gallbladder121.3
heart muscle281.5
kidney178.3
liver94.7
lung209.7
lymph node189.7
ovary165.4
pancreas94.9
placenta124.5
prostate219.1
salivary gland243
skin143.5
small intestine144
spleen242.8
stomach211.7
testis97.9
thyroid gland171.3
urinary bladder166.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*600188, gene) Amino-terminal enhancer of split; AESOMIM


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