Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q08209)
Protein (NX_Q08209)
Protein
Gene SymbolPPP3CA to neXtProt (NX_Q08209)
DescriptionSerine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Chromosome4
Location4q24 (101944566 ~ 102269435) to Ensembl
Sequene Features : Isoforms 5, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cardiac muscle hypertrophy in response to stress
.cellular response to glucose stimulus
.regulation of excitatory postsynaptic membrane potential
  + 20 more...
.protein dimerization activity
.calmodulin-dependent protein phosphatase activity
.enzyme binding
  + 4 more...
.sarcolemma
.Z disc
.calcineurin complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 57 4
2014-09-19protein level
5 42 4
2014-05-27protein level
5 42 5
2014-02-25protein level
4 41 5
2013-12-09protein level
4 36 5
2013-11-01protein level
4 31 3
2013-09-12protein level
4 31 3
2013-08-17protein level
3 31 3
2013-07-15protein level
3 19 1
2013-06-11protein level
3 19 1
2013-02-12protein level
3 3 3
2012-12-20protein level
3 3 3
2012-10-30protein level
3 6 3
2012-10-07protein level
3 6 1
2012-08-24protein level
3 4 1
2012-07-28protein level
3 4 1
2012-06-08protein level
3 4 1
2012-05-07protein level
3 4 1
2012-04-10protein level
2 4 1
2012-01-13protein level
2 2 1
2011-12-20protein level
2 2 1
2011-11-11protein level
2 2 1
2011-08-23protein level
2 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q08209-1
0 16 8 58650.139
NX_Q08209-2
0 16 8 57621.6755
NX_Q08209-3
0 16 6 52638.2761
NX_Q08209-4
1 10 3 31716.1274
NX_Q08209-5
1 11 8 51212.1259
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352922,EBI-1048016 USP14  
  .negative regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of proteasomal protein catabolic process
.regulation of chemotaxis
  + 4 more...
.proteasome binding
.tRNA guanylyltransferase activity
.endopeptidase inhibitor activity
  + 2 more...
.extracellular exosome
.synapse
.cytoplasmic membrane-bounded vesicle
  + 5 more...
2 EBI-352922,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-352922,EBI-915984 PPP3R1  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.positive regulation of NFAT protein import into nucleus
  + 8 more...
.protein domain specific binding
.calmodulin binding
.calcium ion binding
.calcium-dependent protein serine/threonine phosphatase activity
.sarcolemma
.calcineurin complex
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
blood8
bone209
bone marrow20
brain43
cervix61
connective tissue67
ear62
embryonic tissue56
eye62
heart22
intestine8
kidney4
liver19
lung56
lymph node11
mammary gland99
muscle18
nerve193
ovary49
pancreas14
placenta14
prostate163
skin14
testis4
thyroid85
trachea19
uterus43
vascular58
Health State
TissuesTPM*
normal46
breast (mammary gland) tumor85
cervical tumor86
chondrosarcoma205
gastrointestinal tumor16
glioma18
head and neck tumor29
liver tumor20
lung tumor19
non-neoplasia82
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
prostate cancer211
skin tumor15
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult64
embryoid body57
fetus78
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.9
adrenal gland20.1
appendix17.6
bone marrow9.4
cerebral cortex109.4
colon22
duodenum10.8
esophagus26.1
gallbladder24.8
heart muscle10.2
kidney11.5
liver10
lung21.8
lymph node19.7
ovary24
pancreas5.1
placenta13.9
prostate68.3
salivary gland18.7
skin24.2
small intestine12.3
spleen14.3
stomach21.1
testis13.8
thyroid gland23
urinary bladder34.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineLow
colonLow
duodenumLow
endometrium 1Low
epididymisLow
gallbladderLow
hippocampusHigh
kidneyLow
lateral ventricleHigh
lymph nodeLow
nasopharynxLow
oral mucosaLow
ovaryLow
prostateMedium
rectumLow
skin 2Low
small intestineLow
spleenMedium
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*114105, gene) Protein phosphatase 3, catalytic subunit, alpha isoform; PPP3CAOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center