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> Protein (NX_Q08345)
Protein (NX_Q08345)
Protein
Gene SymbolDDR1 to neXtProt (NX_Q08345)
DescriptionEpithelial discoidin domain-containing receptor 1
Chromosome6
Location6p21.33 (30844198 ~ 30867933) to Ensembl
Sequene Features : Isoforms 5, Variants 127, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.smooth muscle cell-matrix adhesion
.mammary gland alveolus development
.branching involved in mammary gland duct morphogenesis
  + 14 more...
.metal ion binding
.protein tyrosine kinase collagen receptor activity
.ATP binding
  + 2 more...
.extracellular exosome
.receptor complex
.integral component of plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 127 15
2014-09-19protein level
5 101 15
2014-05-27protein level
5 95 12
2014-02-25protein level
5 41 12
2013-12-09protein level
5 21 12
2013-11-01protein level
5 21 12
2013-09-12protein level
5 21 12
2013-08-17protein level
5 21 12
2013-07-15protein level
5 21 12
2013-06-11protein level
5 21 12
2013-02-12protein level
5 21 48
2012-12-20protein level
5 19 48
2012-10-30protein level
5 22 39
2012-10-07protein level
5 22 11
2012-08-24protein level
5 22 11
2012-07-28protein level
5 22 11
2012-06-08protein level
5 32 11
2012-05-07protein level
5 32 11
2012-04-10protein level
4 26 11
2012-01-13protein level
4 26 10
2011-12-20protein level
4 22 10
2011-11-11protein level
4 15 10
2011-08-23protein level
4 14 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q08345-1
0 37 1 101062.8008
NX_Q08345-2
0 35 1 97111.6489
NX_Q08345-4
2 9 0 27112.128
NX_Q08345-5
1 37 1 101731.1161
NX_Q08345-6
1 34 1 99000.5294
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-711879,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-711879,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites75
bladder267
brain501
cervix82
connective tissue46
ear62
embryonic tissue192
esophagus99
eye90
heart67
intestine137
kidney42
larynx127
liver34
lung59
lymph node33
mammary gland211
mouth1239
muscle84
nerve128
ovary206
pancreas224
pharynx49
pituitary gland60
placenta120
prostate73
salivary gland49
skin42
spleen18
stomach62
testis353
thymus326
thyroid128
trachea1390
uterus120
Health State
TissuesTPM*
normal196
adrenal tumor79
bladder carcinoma284
breast (mammary gland) tumor300
cervical tumor115
chondrosarcoma60
colorectal tumor213
esophageal tumor115
gastrointestinal tumor67
germ cell tumor558
glioma569
head and neck tumor665
kidney tumor101
leukemia10
liver tumor41
lung tumor19
non-neoplasia41
ovarian tumor262
pancreatic tumor180
primitive neuroectodermal tumor of the CNS39
prostate cancer48
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor199
Developmental Stage
TissuesTPM*
adult199
embryoid body228
blastocyst211
fetus186
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.2
adrenal gland24.3
appendix18.3
bone marrow1.2
cerebral cortex119.3
colon60.7
duodenum53.5
esophagus68.9
gallbladder61.1
heart muscle19.5
kidney50.7
liver4.2
lung49.9
lymph node6.5
ovary27.8
pancreas40.3
placenta31.3
prostate57.8
salivary gland75.1
skin108
small intestine57.7
spleen10.1
stomach90.2
testis18.5
thyroid gland84.8
urinary bladder52.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600408, gene) Discoidin domain receptor family, member 1; DDR1OMIM


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