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> Protein (NX_Q08426)
Protein (NX_Q08426)
Protein
Gene SymbolEHHADH to neXtProt (NX_Q08426)
DescriptionPeroxisomal bifunctional enzyme
Chromosome3
Location3q27.2 (184908412 ~ 184999778) to Ensembl
Sequene Features : Isoforms 2, Variants 127, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 127 23
2014-09-19protein level
2 107 23
2014-05-27protein level
2 106 23
2014-02-25protein level
2 106 12
2013-12-09protein level
2 86 12
2013-11-01protein level
2 86 11
2013-09-12protein level
2 86 5
2013-08-17protein level
2 86 5
2013-07-15protein level
2 64 5
2013-06-11protein level
2 64 5
2013-02-12protein level
2 44 10
2012-12-20protein level
2 44 10
2012-10-30protein level
2 50 10
2012-10-07protein level
2 50 5
2012-08-24protein level
2 45 5
2012-07-28protein level
2 45 5
2012-06-08protein level
2 51 5
2012-05-07protein level
2 51 5
2012-04-10protein level
2 51 5
2012-01-13protein level
1 29 5
2011-12-20protein level
1 29 5
2011-11-11protein level
1 29 5
2011-08-23protein level
1 29 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q08426-1
7 34 0 79444.5059
NX_Q08426-2
1 34 0 69109.9046
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2339219,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-2339219,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
3 EBI-2339219,EBI-2515299 SSNA1  
  .ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
.organelle organization
  + 2 more...
.N/A .ciliary basal body
.cytosol
.centrosome
.nucleus
4 EBI-2339219,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
5 EBI-2339219,EBI-1055572 DES  
  .muscle filament sliding
.regulation of heart contraction
.cytoskeleton organization
.muscle contraction
.identical protein binding
.cytoskeletal protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.sarcolemma
.neuromuscular junction
  + 4 more...
6 EBI-2339219,EBI-1044672 TPP2  
  .proteolysis
.antigen processing and presentation of peptide antigen via MHC class I
.protein polyubiquitination
.peptide binding
.tripeptidyl-peptidase activity
.serine-type endopeptidase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
7 EBI-2339219,EBI-740135 CBS  
  .hydrogen sulfide biosynthetic process
.oxidation-reduction process
.homocysteine metabolic process
  + 12 more...
.S-adenosyl-L-methionine binding
.modified amino acid binding
.nitric oxide binding
  + 11 more...
.intracellular membrane-bounded organelle
.cytosol
.nucleolus
.nucleus
8 EBI-2339219,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
9 EBI-2339219,EBI-351292 ACTG1  
  .platelet aggregation
.membrane organization
.ephrin receptor signaling pathway
  + 11 more...
.identical protein binding
.ubiquitin protein ligase binding
.ATP binding
.structural constituent of cytoskeleton
.blood microparticle
.extracellular exosome
.filamentous actin
  + 7 more...
10 EBI-2339219,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
11 EBI-2339219,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
12 EBI-2339219,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
13 EBI-2339219,EBI-3059266 FUNDC1  
  .response to hypoxia
.mitochondrion degradation
.N/A .integral component of mitochondrial outer membrane
.mitochondrial outer membrane
14 EBI-2339219,EBI-2511344 KCTD6  
  .protein homooligomerization .ankyrin binding .N/A
15 EBI-2339219,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
16 EBI-2339219,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
17 EBI-2339219,EBI-395708 ZBTB9  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
18 EBI-2339219,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
19 EBI-2339219,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
20 EBI-2339219,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain11
cervix20
connective tissue6
eye23
heart11
intestine12
kidney75
larynx42
liver136
lung2
lymph node22
mammary gland33
mouth75
muscle28
placenta10
prostate36
salivary gland49
skin9
spleen18
stomach10
testis9
thymus12
trachea173
uterus21
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor32
cervical tumor28
colorectal tumor8
gastrointestinal tumor8
germ cell tumor11
head and neck tumor44
kidney tumor14
liver tumor104
non-neoplasia20
primitive neuroectodermal tumor of the CNS7
prostate cancer48
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult21
neonate32
fetus55
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.4
adrenal gland4.6
appendix3
bone marrow1.2
cerebral cortex2.7
colon15
duodenum19.1
esophagus6.8
gallbladder5
heart muscle8.8
kidney117.1
liver167.7
lung4.3
lymph node2.1
ovary3.1
pancreas5.7
placenta2.4
prostate7
salivary gland4.2
skin3.9
small intestine12
spleen3.4
stomach9.1
testis3.2
thyroid gland6.4
urinary bladder6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusLow
kidneyHigh
lateral ventricleLow
liverHigh
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2High
stomach 1Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607037, gene) Enoyl-coa hydratase/3-hydroxyacyl coa dehydrogenase; EHHADHOMIM


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