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> Protein (NX_Q08AM6)
Protein (NX_Q08AM6)
Protein
Gene SymbolVAC14 to neXtProt (NX_Q08AM6)
DescriptionProtein VAC14 homolog
Chromosome16
Location16q22.1 (70721342 ~ 70835064) to Ensembl
Sequene Features : Isoforms 2, Variants 74, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 74 4
2014-09-19protein level
1 62 4
2014-05-27protein level
1 62 4
2014-02-25protein level
1 62 4
2013-12-09protein level
1 49 4
2013-11-01protein level
1 45 4
2013-09-12protein level
1 45 3
2013-08-17protein level
1 45 3
2013-07-15protein level
1 29 3
2013-06-11protein level
1 29 3
2013-02-12protein level
1 12 6
2012-12-20protein level
1 12 6
2012-10-30protein level
1 15 6
2012-10-07protein level
1 15 6
2012-08-24protein level
1 9 6
2012-07-28protein level
1 9 6
2012-06-08protein level
1 18 6
2012-05-07protein level
1 18 6
2012-04-10protein level
1 18 6
2012-01-13protein level
1 14 6
2011-12-20protein level
1 14 6
2011-11-11protein level
1 14 5
2011-08-23protein level
1 14 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q08AM6-1
29 9 0 87916.4581
NX_Q08AM6-2
0 9 0 24766.8853
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2107455,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-2107455,EBI-750381 SIGLEC5  
  .cell adhesion .carbohydrate binding .integral component of membrane
3 EBI-2107455,EBI-530034 PHF1  
  .positive regulation of histone H3-K27 methylation
.negative regulation of histone H3-K27 methylation
.negative regulation of gene expression, epigenetic
  + 5 more...
.methylated histone binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.site of double-strand break
.microtubule organizing center
.cytoplasm
  + 2 more...
4 EBI-2107455,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-2107455,EBI-9090173 JMJD7  
  .N/A .N/A .N/A
6 EBI-2107455,EBI-747133 COL8A1  
  .epithelial cell proliferation
.camera-type eye morphogenesis
.endodermal cell differentiation
  + 6 more...
.N/A .extracellular exosome
.intracellular membrane-bounded organelle
.endoplasmic reticulum lumen
  + 2 more...
7 EBI-2107455,EBI-516667 CASP1  
  .toxin transport
.programmed necrotic cell death
.cellular response to organic substance
  + 19 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.cysteine-type endopeptidase activity
.endopeptidase activity
.AIM2 inflammasome complex
.NLRP3 inflammasome complex
.NLRP1 inflammasome complex
  + 4 more...
8 EBI-2107455,EBI-7164065 NOS1  
  .regulation of generation of L-type calcium current
.positive regulation of sodium ion transmembrane transport
.positive regulation of adrenergic receptor signaling pathway involved in heart process
  + 31 more...
.scaffold protein binding
.NADP binding
.flavin adenine dinucleotide binding
  + 11 more...
.perinuclear region of cytoplasm
.synapse
.membrane raft
  + 9 more...
9 EBI-2107455,EBI-10172814 PRR20C  
  .N/A .N/A .N/A
10 EBI-2107455,EBI-396540 TP53BP1  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 5 more...
.telomeric DNA binding
.methylated histone binding
.damaged DNA binding
  + 3 more...
.cytoplasm
.replication fork
.nucleoplasm
  + 2 more...
11 EBI-2107455,EBI-2350461 MPPED2  
  .nervous system development .metal ion binding
.hydrolase activity
.N/A
12 EBI-2107455,EBI-10238012 LPAL2  
  .N/A .N/A .extracellular region
13 EBI-2107455,EBI-10238309 CCBL1  
  .L-kynurenine catabolic process
.kynurenine metabolic process
.small molecule metabolic process
  + 5 more...
.L-glutamine:pyruvate aminotransferase activity
.cysteine-S-conjugate beta-lyase activity
.glutamine-phenylpyruvate transaminase activity
  + 5 more...
.cytosol
.cytoplasm
.nucleoplasm
14 EBI-2107455,EBI-1048945 KRTAP19-5  
  .N/A .N/A .intermediate filament
15 EBI-2107455,EBI-10241353 KRTAP19-7  
  .N/A .N/A .intermediate filament
16 EBI-2107455,EBI-10242151 FNDC3B  
  .N/A .poly(A) RNA binding .integral component of membrane
17 EBI-2107455,EBI-749970 SMUG1  
  .depyrimidination
.base-excision repair, AP site formation
.base-excision repair
  + 2 more...
.DNA N-glycosylase activity
.single-strand selective uracil DNA N-glycosylase activity
.uracil DNA N-glycosylase activity
  + 2 more...
.intracellular membrane-bounded organelle
.nucleolus
.nucleoplasm
18 EBI-2107455,EBI-10248098 SPRYD7  
  .N/A .N/A .N/A
19 EBI-2107455,EBI-751947 PHYKPL  
  .N/A .pyridoxal phosphate binding
.lyase activity
.transaminase activity
.mitochondrion
20 EBI-2107455,EBI-10261970 CCDC103  
  .determination of digestive tract left/right asymmetry
.axonemal dynein complex assembly
.epithelial cilium movement involved in determination of left/right asymmetry
  + 5 more...
.protein homodimerization activity .motile cilium
.axoneme
.cytoplasm
21 EBI-2107455,EBI-10264496 ZNF34  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.nucleus
22 EBI-2107455,EBI-10264791 LINC00518  
  .N/A .N/A .N/A
23 EBI-2107455,EBI-10264911 C4orf33  
  .N/A .N/A .N/A
24 EBI-2107455,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
25 EBI-2107455,EBI-707573 ASB13  
  .intracellular signal transduction
.protein ubiquitination
.N/A .N/A
26 EBI-2107455,EBI-448369 PELI1  
  .protein K48-linked ubiquitination
.innate immune response
.response to dsRNA
  + 19 more...
.ligase activity
.ubiquitin-protein transferase activity
.cytosol
.nucleus
27 EBI-2107455,EBI-747719 SNF8  
  .regulation of viral budding via host ESCRT complex
.positive regulation of exosomal secretion
.regulation of protein complex stability
  + 11 more...
.protein N-terminus binding
.protein homodimerization activity
.channel regulator activity
  + 2 more...
.extracellular exosome
.recycling endosome
.perinuclear region of cytoplasm
  + 10 more...
28 EBI-2107455,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
29 EBI-2107455,EBI-744593 MTMR9  
  .N/A .enzyme regulator activity .cytoplasm
30 EBI-2107455,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
31 EBI-2107455,EBI-10297527 PRADC1  
  .N/A .N/A .extracellular exosome
.extracellular region
32 EBI-2107455,EBI-740204 C11orf54  
  .metabolic process .hydrolase activity, acting on ester bonds
.zinc ion binding
.extracellular exosome
.nucleus
33 EBI-2107455,EBI-9257341 CD209  
  .intracellular transport of virus
.peptide antigen transport
.innate immune response
  + 11 more...
.metal ion binding
.virion binding
.peptide antigen binding
  + 2 more...
.extracellular exosome
.integral component of membrane
.membrane
  + 3 more...
34 EBI-2107455,EBI-10311409 NGB  
  .oxygen transport
.apoptotic process
.heme binding
.iron ion binding
.oxygen transporter activity
.perikaryon
.mitochondrion
35 EBI-2107455,EBI-10313831 ACSS1  
  .small molecule metabolic process
.propionate biosynthetic process
.acetyl-CoA biosynthetic process from acetate
  + 4 more...
.AMP binding
.ATP binding
.acetate-CoA ligase activity
.mitochondrial matrix
36 EBI-2107455,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
37 EBI-2107455,EBI-6138650 PIKFYVE  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.retrograde transport, endosome to Golgi
  + 6 more...
.metal ion binding
.phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
.1-phosphatidylinositol-4-phosphate 5-kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.membrane raft
.late endosome membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
blood65
bone69
bone marrow102
brain37
cervix185
connective tissue67
embryonic tissue75
eye76
heart22
intestine60
kidney47
larynx42
liver29
lung65
lymph248
lymph node11
mammary gland33
nerve193
ovary68
pancreas56
placenta45
prostate31
salivary gland49
skin137
spleen37
testis68
thymus50
trachea19
umbilical cord72
uterus60
vascular19
Health State
TissuesTPM*
normal37
breast (mammary gland) tumor32
chondrosarcoma181
colorectal tumor106
gastrointestinal tumor25
germ cell tumor87
glioma167
head and neck tumor14
kidney tumor29
leukemia63
liver tumor62
lung tumor87
lymphoma152
non-neoplasia10
ovarian tumor52
pancreatic tumor28
primitive neuroectodermal tumor of the CNS47
prostate cancer57
retinoblastoma86
skin tumor135
soft tissue/muscle tissue tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult49
embryoid body71
blastocyst113
neonate32
fetus39
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.1
adrenal gland10.4
appendix17.5
bone marrow10.4
cerebral cortex12.9
colon12.7
duodenum12
esophagus12.9
gallbladder12.8
heart muscle12.9
kidney14.9
liver6.3
lung14.8
lymph node28.2
ovary12.4
pancreas9
placenta12.8
prostate10.6
salivary gland12.8
skin16.7
small intestine12.9
spleen18.4
stomach11.7
testis16.8
thyroid gland20.7
urinary bladder15.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604632, gene) Vac14, s. cerevisiae, homolog of; VAC14OMIM


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