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> Protein (NX_Q09472)
Protein (NX_Q09472)
Protein
Gene SymbolEP300 to neXtProt (NX_Q09472)
DescriptionHistone acetyltransferase p300
Chromosome22
Location22q13.2 (41487790 ~ 41576081) to Ensembl
Sequene Features : Isoforms 1, Variants 308, PTMs 43 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 308 43
2014-09-19protein level
1 257 43
2014-05-27protein level
1 257 40
2014-02-25protein level
1 254 42
2013-12-09protein level
1 208 42
2013-11-01protein level
1 173 37
2013-09-12protein level
1 173 37
2013-08-17protein level
1 173 37
2013-07-15protein level
1 138 37
2013-06-11protein level
1 138 37
2013-02-12protein level
1 70 33
2012-12-20protein level
1 70 33
2012-10-30protein level
1 80 33
2012-10-07protein level
1 80 33
2012-08-24protein level
1 72 39
2012-07-28protein level
1 72 39
2012-06-08protein level
1 66 39
2012-05-07protein level
1 66 39
2012-04-10protein level
1 66 39
2012-01-13protein level
1 48 39
2011-12-20protein level
1 48 39
2011-11-11protein level
1 44 35
2011-08-23protein level
1 42 34
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q09472-1
65 0 18 263989.6412
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-447295,EBI-494844 NBN  
  .intrinsic apoptotic signaling pathway
.meiotic cell cycle
.neuromuscular process controlling balance
  + 16 more...
.protein N-terminus binding
.transcription factor binding
.damaged DNA binding
.nuclear inclusion body
.site of double-strand break
.Mre11 complex
  + 6 more...
2 EBI-447295,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
3 EBI-447295,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-447295,EBI-347351 TFAP2A  
  .negative regulation of reactive oxygen species metabolic process
.metanephric nephron development
.basement membrane organization
  + 43 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 14 more...
.intracellular membrane-bounded organelle
.centrosome
.Golgi apparatus
  + 3 more...
5 EBI-447295,EBI-286357 VDR  
  .vitamin D receptor signaling pathway
.mammary gland branching involved in pregnancy
.regulation of calcidiol 1-monooxygenase activity
  + 20 more...
.lithocholic acid binding
.calcitriol binding
.retinoid X receptor binding
  + 6 more...
.RNA polymerase II transcription factor complex
.receptor complex
.nucleoplasm
.nucleus
6 EBI-447295,EBI-711855 CREB1  
  .cellular response to zinc ion
.Type I pneumocyte differentiation
.lung saccule development
  + 45 more...
.cAMP response element binding
.enzyme binding
.transcription cofactor activity
  + 7 more...
.ATF4-CREB1 transcription factor complex
.nuclear euchromatin
.nucleoplasm
.nucleus
7 EBI-447295,EBI-351962 DDX5  
  .regulation of skeletal muscle cell differentiation
.intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of androgen receptor signaling pathway
  + 13 more...
.androgen receptor binding
.poly(A) RNA binding
.pre-mRNA binding
  + 5 more...
.catalytic step 2 spliceosome
.extracellular exosome
.ribonucleoprotein complex
  + 5 more...
8 EBI-447295,EBI-1167176 POU3F2  
  .cellular response to organic substance
.regulation of axonogenesis
.positive regulation of multicellular organism growth
  + 9 more...
.sequence-specific DNA binding
.identical protein binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription coactivator activity
.transcription factor complex
.nucleus
9 EBI-447295,EBI-375096 CDK2  
  .cellular response to nitric oxide
.regulation of gene silencing
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 20 more...
.metal ion binding
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.Cajal body
.cytosol
.centrosome
  + 10 more...
10 EBI-447295,EBI-1048805 APEX1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of G1/S transition of mitotic cell cycle
.DNA demethylation
  + 25 more...
.metal ion binding
.poly(A) RNA binding
.chromatin DNA binding
  + 15 more...
.perinuclear region of cytoplasm
.nuclear speck
.ribosome
  + 8 more...
11 EBI-447295,EBI-1186478 STAT6  
  .cellular response to reactive nitrogen species
.cellular response to hydrogen peroxide
.mammary gland morphogenesis
  + 13 more...
.identical protein binding
.protein phosphatase binding
.signal transducer activity
  + 2 more...
.membrane raft
.cytosol
.cytoplasm
  + 2 more...
12 EBI-447295,EBI-356392 NAP1L1  
  .positive regulation of cell proliferation
.nucleosome assembly
.DNA replication
.poly(A) RNA binding .melanosome
.membrane
.nucleus
13 EBI-447295,EBI-1050386 COPS2  
  .negative regulation of nucleic acid-templated transcription
.skeletal muscle cell differentiation
.neuron differentiation
  + 5 more...
.signal transducer activity
.transcription corepressor activity
.COP9 signalosome
.cytoplasm
14 EBI-447295,EBI-354065 YBX1  
  .CRD-mediated mRNA stabilization
.positive regulation of cell division
.negative regulation of striated muscle cell differentiation
  + 8 more...
.GTPase binding
.poly(A) RNA binding
.RNA binding
  + 6 more...
.histone pre-mRNA 3'end processing complex
.CRD-mediated mRNA stability complex
.extracellular exosome
  + 8 more...
15 EBI-447295,EBI-389564 GTF2B  
  .viral process
.gene expression
.transcription elongation from RNA polymerase II promoter
  + 3 more...
.thyroid hormone receptor binding
.zinc ion binding
.transcription factor binding
.core promoter binding
.nucleolus
.nucleoplasm
.nucleus
16 EBI-447295,EBI-456291 SKP2  
  .cellular response to cell-matrix adhesion
.regulation of cell cycle
.positive regulation of smooth muscle cell proliferation
  + 8 more...
.identical protein binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.aggresome
.cytosol
  + 4 more...
17 EBI-447295,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
18 EBI-447295,EBI-925990 RUNX3  
  .positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of epithelial cell proliferation
.peripheral nervous system neuron development
  + 14 more...
.ATP binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.RNA polymerase II regulatory region sequence-specific DNA binding
.intracellular membrane-bounded organelle
.Golgi apparatus
.cytoplasm
  + 3 more...
19 EBI-447295,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
20 EBI-447295,EBI-5550163 PPP1R13L  
  .cardiac muscle contraction
.multicellular organismal homeostasis
.hair cycle
  + 8 more...
.identical protein binding
.transcription factor binding
.transcription corepressor activity
.intercellular bridge
.cell junction
.cytoplasm
.nucleus
21 EBI-447295,EBI-477430 KAT2B  
  .rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 19 more...
.histone deacetylase binding
.protein complex binding
.protein kinase binding
  + 7 more...
.actomyosin
.I band
.A band
  + 5 more...
22 EBI-447295,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
23 EBI-447295,EBI-1105153 PPP1R13B  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
.N/A .plasma membrane
.cytoplasm
.nucleoplasm
.nucleus
24 EBI-447295,EBI-937732 CITED2  
  .positive regulation of male gonad development
.regulation of nucleic acid-templated transcription
.nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
  + 29 more...
.LBD domain binding
.histone acetyltransferase binding
.transcription corepressor activity
  + 4 more...
.cytoplasm
.nucleus
.nuclear chromatin
25 EBI-447295,EBI-348345 HIPK2  
  .intrinsic apoptotic signaling pathway
.cellular response to hypoxia
.iris morphogenesis
  + 34 more...
.virion binding
.SMAD binding
.ATP binding
  + 5 more...
.RNA polymerase II transcription factor complex
.PML body
.nuclear body
  + 2 more...
26 EBI-447295,EBI-711221 BRD7  
  .negative regulation of G1/S transition of mitotic cell cycle
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 6 more...
.lysine-acetylated histone binding
.transcription regulatory region DNA binding
.histone binding
  + 4 more...
.cytoplasm
.nucleus
27 EBI-447295,EBI-540797 ASH2L  
  .histone H3-K4 methylation
.positive regulation of transcription from RNA polymerase II promoter
.response to estrogen
  + 7 more...
.metal ion binding
.transcription regulatory region DNA binding
.DNA binding
.Set1C/COMPASS complex
.histone methyltransferase complex
.nucleoplasm
.nucleus
28 EBI-447295,EBI-81196 NCOA3  
  .regulation of RNA biosynthetic process
.mammary gland branching involved in thelarche
.labyrinthine layer morphogenesis
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.thyroid hormone receptor binding
  + 7 more...
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder33
blood204
bone13
brain1
cervix41
connective tissue26
embryonic tissue131
esophagus49
eye43
heart11
intestine99
kidney33
larynx468
liver34
lung47
lymph22
lymph node222
mammary gland105
mouth45
muscle9
nerve64
ovary9
pancreas9
parathyroid145
pharynx49
placenta102
prostate21
skin42
spleen74
stomach62
testis22
thymus12
thyroid150
uterus60
Health State
TissuesTPM*
normal1
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor128
cervical tumor57
chondrosarcoma36
colorectal tumor159
esophageal tumor57
gastrointestinal tumor8
germ cell tumor3
glioma18
head and neck tumor141
kidney tumor14
leukemia232
liver tumor62
lung tumor19
lymphoma13
non-neoplasia41
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma129
skin tumor7
soft tissue/muscle tissue tumor55
uterine tumor77
Developmental Stage
TissuesTPM*
adult89
embryoid body142
blastocyst195
fetus1
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.9
adrenal gland10.8
appendix15.1
bone marrow33.5
cerebral cortex9.6
colon12.9
duodenum10.7
esophagus11.7
gallbladder13.6
heart muscle7.9
kidney12.4
liver8.1
lung12.6
lymph node14.9
ovary20.4
pancreas7.5
placenta17.3
prostate12.1
salivary gland9.3
skin13.2
small intestine11
spleen14.4
stomach12.3
testis20.8
thyroid gland17.6
urinary bladder14.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602700, gene) E1a-binding protein, 300-kd; EP300OMIM
2(#613684, phenotype) Rubinstein-taybi syndrome 2; RSTS2OMIM
3colorectal;breast;pancreatic;acute myelogenous leukemia;acute lymphocytic leukemia;diffuse large B-cell lymphomaCGP


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