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> Protein (NX_Q0D2K3)
Protein (NX_Q0D2K3)
Protein
Gene SymbolRIPPLY1 to neXtProt (NX_Q0D2K3)
DescriptionProtein ripply1
ChromosomeX
LocationXq22.3 (106143293 ~ 106146565) to Ensembl
Sequene Features : Isoforms 2, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.bone morphogenesis
.negative regulation of transcription, DNA-templated
.somite rostral/caudal axis specification
  + 4 more...
.N/A .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
2 18 0
2014-09-19transcript level
2 14 0
2014-05-27transcript level
2 14 0
2014-02-25transcript level
2 14 0
2013-12-09transcript level
2 11 0
2013-11-01transcript level
2 11 0
2013-09-12transcript level
2 11 0
2013-08-17transcript level
2 11 0
2013-07-15transcript level
2 7 0
2013-06-11transcript level
2 7 0
2013-02-12transcript level
2 3 0
2012-12-20transcript level
2 0 0
2012-10-30transcript level
2 2 0
2012-10-07transcript level
2 2 0
2012-08-24transcript level
2 2 0
2012-07-28transcript level
2 2 0
2012-06-08transcript level
2 2 0
2012-05-07transcript level
2 2 0
2012-04-10transcript level
2 2 0
2012-01-13transcript level
2 1 0
2011-12-20transcript level
2 1 0
2011-11-11transcript level
2 1 0
2011-08-23transcript level
2 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q0D2K3-1
2 2 0 16368.9167
NX_Q0D2K3-2
0 2 0 11212.3016
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10226430,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
2 EBI-10226430,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
3 EBI-10226430,EBI-10276431 HDAC7  
  .positive regulation of cell migration involved in sprouting angiogenesis
.negative regulation of osteoblast differentiation
.cellular protein metabolic process
  + 8 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.14-3-3 protein binding
.repressing transcription factor binding
  + 9 more...
.cytoplasm
.nucleoplasm
.nucleus
.histone deacetylase complex
4 EBI-10226430,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
5 EBI-10226430,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
6 EBI-10226430,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain2
kidney4
liver4
uterus4
Health State
TissuesTPM*
liver tumor10
non-neoplasia31
uterine tumor11
Developmental Stage
TissuesTPM*
adult1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
kidney2.5
liver3.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300575, gene) Ripply1, zebrafish, homolog of; RIPPLY1OMIM


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