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> Protein (NX_Q0VD86)
Protein (NX_Q0VD86)
Protein
Gene SymbolINCA1 to neXtProt (NX_Q0VD86)
DescriptionProtein INCA1
Chromosome17
Location17p13.2 (4891425 ~ 4900905) to Ensembl
Sequene Features : Isoforms 2, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 25 4
2014-09-19protein level
2 21 4
2014-05-27protein level
2 21 4
2014-02-25protein level
2 21 4
2013-12-09protein level
2 11 4
2013-11-01protein level
2 8 4
2013-09-12protein level
2 8 4
2013-08-17protein level
2 8 4
2013-07-15protein level
2 5 4
2013-06-11protein level
2 5 4
2013-02-12protein level
2 4 8
2012-12-20protein level
2 5 8
2012-10-30protein level
2 4 8
2012-10-07protein level
2 4 4
2012-08-24protein level
2 3 4
2012-07-28protein level
2 3 4
2012-06-08protein level
2 8 4
2012-05-07protein level
2 8 4
2012-04-10protein level
2 8 4
2012-01-13protein level
2 7 4
2011-12-20protein level
2 7 4
2011-11-11protein level
2 7 4
2011-08-23protein level
2 7 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q0VD86-1
2 10 0 26800.3452
NX_Q0VD86-2
1 10 0 25199.5829
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6509505,EBI-1044156 SAP18  
  .negative regulation of nucleic acid-templated transcription
.negative regulation of mRNA splicing, via spliceosome
.negative regulation of gene expression, epigenetic
  + 9 more...
.poly(A) RNA binding
.transcription corepressor activity
.ASAP complex
.nuclear speck
.cytoplasm
  + 2 more...
2 EBI-6509505,EBI-10182490 EPHB6  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.ephrin receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.cytosol
.extracellular region
3 EBI-6509505,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
4 EBI-6509505,EBI-3921553 ZNF16  
  .positive regulation of cell cycle phase transition
.cellular response to sodium dodecyl sulfate
.positive regulation of cell division
  + 9 more...
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
5 EBI-6509505,EBI-747133 COL8A1  
  .epithelial cell proliferation
.camera-type eye morphogenesis
.endodermal cell differentiation
  + 6 more...
.N/A .extracellular exosome
.intracellular membrane-bounded organelle
.endoplasmic reticulum lumen
  + 2 more...
6 EBI-6509505,EBI-745859 CDKN2D  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of protein serine/threonine kinase activity
.autophagic cell death
  + 13 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
7 EBI-6509505,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
8 EBI-6509505,EBI-701903 FHL2  
  .heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
9 EBI-6509505,EBI-1993619 UBXN2B  
  .membrane fusion
.regulation of catalytic activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin binding
.protein phosphatase type 1 regulator activity
.cytosol
.Golgi apparatus
.endoplasmic reticulum
.nucleus
10 EBI-6509505,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
11 EBI-6509505,EBI-10277790 PATE1  
  .N/A .N/A .extracellular region
12 EBI-6509505,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
13 EBI-6509505,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
14 EBI-6509505,EBI-746595 ZMYND19  
  .N/A .metal ion binding .synapse
.plasma membrane
.cytoplasm
15 EBI-6509505,EBI-745021 STAMBPL1  
  .N/A .metal ion binding
.metallopeptidase activity
.membrane
16 EBI-6509505,EBI-744023 FAM103A1  
  .recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
.methylation
.7-methylguanosine mRNA capping
.poly(A) RNA binding
.RNA binding
.mRNA cap binding complex
.nucleus
17 EBI-6509505,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
18 EBI-6509505,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
19 EBI-6509505,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
20 EBI-6509505,EBI-10311131 CABP5  
  .signal transduction .calcium ion binding .cytosol
21 EBI-6509505,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
22 EBI-6509505,EBI-747082 CTNNBIP1  
  .negative regulation of mesenchymal cell proliferation
.negative regulation of transcription initiation from RNA polymerase II promoter
.negative regulation of smooth muscle cell proliferation
  + 10 more...
.armadillo repeat domain binding
.beta-catenin binding
.beta-catenin destruction complex
.cytosol
.cytoplasm
  + 2 more...
23 EBI-6509505,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
24 EBI-6509505,EBI-10320311 SEC14L4  
  .N/A .lipid binding
.transporter activity
.integral component of membrane
.intracellular
25 EBI-6509505,EBI-9057006 OSGIN1  
  .positive regulation of apoptotic process
.negative regulation of cell growth
.cell differentiation
.multicellular organismal development
.growth factor activity .N/A
26 EBI-6509505,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
27 EBI-6509505,EBI-745527 UBE2D4  
  .protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
28 EBI-6509505,EBI-2321769 CHCHD2  
  .regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
embryonic tissue4
lung2
ovary9
skin4
testis25
Health State
TissuesTPM*
normal2
bladder carcinoma56
lung tumor9
ovarian tumor13
Developmental Stage
TissuesTPM*
adult1
embryoid body14
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.2
appendix1.6
cerebral cortex2.3
colon1.4
duodenum2
esophagus1.2
gallbladder1.6
heart muscle2.6
kidney1.8
lung3.1
lymph node1
ovary2.6
prostate2.3
small intestine2.4
spleen2.2
stomach1
testis27
thyroid gland1.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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