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> Protein (NX_Q12774)
Protein (NX_Q12774)
Protein
Gene SymbolARHGEF5 to neXtProt (NX_Q12774)
DescriptionRho guanine nucleotide exchange factor 5
Chromosome7
Location7q35 (144052381 ~ 144077725) to Ensembl
Sequene Features : Isoforms 2, Variants 95, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of podosome assembly
.regulation of GTPase activity
.intracellular signal transduction
  + 2 more...
.GTP binding
.Rho guanyl-nucleotide exchange factor activity
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 95 14
2014-09-19protein level
2 61 14
2014-05-27protein level
2 61 16
2014-02-25protein level
2 62 15
2013-12-09protein level
2 53 15
2013-11-01protein level
2 53 15
2013-09-12protein level
2 53 15
2013-08-17protein level
2 53 15
2013-07-15protein level
2 39 15
2013-06-11protein level
2 39 15
2013-02-12protein level
2 20 20
2012-12-20protein level
2 20 20
2012-10-30protein level
2 15 20
2012-10-07protein level
2 15 14
2012-08-24protein level
2 15 14
2012-07-28protein level
2 16 14
2012-06-08protein level
2 18 14
2012-05-07protein level
2 13 14
2012-04-10protein level
2 13 14
2012-01-13protein level
2 9 14
2011-12-20protein level
2 9 14
2011-11-11protein level
2 9 12
2011-08-23protein level
2 9 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12774-1
33 29 13 176689.9511
NX_Q12774-2
0 29 0 60018.6621
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-602199,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-602199,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-602199,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
4 EBI-602199,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
5 EBI-602199,EBI-720457 HSPBAP1  
  .N/A .N/A .cytoplasm
6 EBI-602199,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder100
bone13
bone marrow20
embryonic tissue18
eye4
intestine25
kidney14
lung23
mammary gland85
mouth15
muscle9
pancreas4
placenta3
prostate5
skin9
testis2
thyroid21
uterus4
Health State
TissuesTPM*
normal11
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor25
germ cell tumor15
glioma9
head and neck tumor22
kidney tumor101
leukemia10
lung tumor29
non-neoplasia10
pancreatic tumor19
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult17
embryoid body14
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2
adrenal gland1.4
appendix2.9
bone marrow2.1
colon11.7
duodenum13.4
esophagus13.5
gallbladder7.7
kidney8.5
liver3.6
lung6.7
lymph node2.2
ovary3.6
pancreas5.8
placenta7.3
prostate8.7
salivary gland9
skin20.3
small intestine12
spleen2
stomach11
testis1.7
thyroid gland21.6
urinary bladder5.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600888, gene) Rho guanine nucleotide exchange factor 5; ARHGEF5OMIM


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