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> Protein (NX_Q12800)
Protein (NX_Q12800)
Protein
Gene SymbolTFCP2 to neXtProt (NX_Q12800)
DescriptionAlpha-globin transcription factor CP2
Chromosome12
Location12q13.12 (51487446 ~ 51566926) to Ensembl
Sequene Features : Isoforms 4, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 46 0
2014-09-19protein level
4 33 0
2014-05-27protein level
4 33 1
2014-02-25protein level
4 33 1
2013-12-09protein level
4 29 1
2013-11-01protein level
4 27 1
2013-09-12protein level
4 27 1
2013-08-17protein level
4 27 1
2013-07-15protein level
4 16 0
2013-06-11protein level
4 16 0
2013-02-12protein level
4 3 0
2012-12-20protein level
4 3 0
2012-10-30protein level
4 4 0
2012-10-07protein level
4 4 0
2012-08-24protein level
4 1 0
2012-07-28protein level
4 1 0
2012-06-08protein level
4 8 0
2012-05-07protein level
4 8 0
2012-04-10protein level
4 8 0
2012-01-13protein level
4 8 0
2011-12-20protein level
4 8 0
2011-11-11protein level
4 8 0
2011-08-23protein level
4 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12800-1
0 16 3 57219.56
NX_Q12800-2
0 15 3 51275.6731
NX_Q12800-3
0 15 3 51346.71
NX_Q12800-4
0 16 3 57148.5231
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717422,EBI-7779316 E2F8  
  .hepatocyte differentiation
.chorionic trophoblast cell differentiation
.trophoblast giant cell differentiation
  + 8 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.transcription factor complex
.nucleus
2 EBI-717422,EBI-10171490 KIAA1598  
  .regulation of neuron migration
.regulation of establishment of cell polarity
.axon guidance
.N/A .axonal growth cone
3 EBI-717422,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
4 EBI-717422,EBI-2861268 PITPNM1  
  .phospholipid transport
.protein transport
.phototransduction
  + 2 more...
.metal ion binding
.phosphatidylinositol transporter activity
.Golgi cisterna membrane
.cleavage furrow
.midbody
  + 4 more...
5 EBI-717422,EBI-530034 PHF1  
  .positive regulation of histone H3-K27 methylation
.negative regulation of histone H3-K27 methylation
.negative regulation of gene expression, epigenetic
  + 5 more...
.methylated histone binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.site of double-strand break
.microtubule organizing center
.cytoplasm
  + 2 more...
6 EBI-717422,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
7 EBI-717422,EBI-2466403 TSPAN12  
  .regulation of angiogenesis
.retina layer formation
.cell surface receptor signaling pathway
.angiogenesis
.N/A .integral component of membrane
.membrane
.integral component of plasma membrane
8 EBI-717422,EBI-751540 GPANK1  
  .N/A .nucleic acid binding .N/A
9 EBI-717422,EBI-3912102 CA1  
  .small molecule metabolic process
.bicarbonate transport
.one-carbon metabolic process
.hydro-lyase activity
.zinc ion binding
.carbonate dehydratase activity
.arylesterase activity
.extracellular exosome
.cytosol
10 EBI-717422,EBI-5462600 RBMS1  
  .RNA processing
.DNA replication
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.nucleus
11 EBI-717422,EBI-347552 BAG6  
  .tail-anchored membrane protein insertion into ER membrane
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.protein stabilization
  + 17 more...
.proteasome binding
.ribosome binding
.ubiquitin protein ligase binding
.polyubiquitin binding
.BAT3 complex
.intracellular membrane-bounded organelle
.cytosol
  + 3 more...
12 EBI-717422,EBI-6657604 ADPRH  
  .protein de-ADP-ribosylation
.cellular protein modification process
.ADP-ribosylarginine hydrolase activity
.magnesium ion binding
.N/A
13 EBI-717422,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
14 EBI-717422,EBI-396072 PPIG  
  .RNA splicing
.protein folding
.protein peptidyl-prolyl isomerization
.poly(A) RNA binding
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
15 EBI-717422,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
16 EBI-717422,EBI-752143 PSMD5  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteasome regulatory particle assembly
  + 22 more...
.N/A .proteasome accessory complex
.cytosol
.nucleoplasm
.proteasome complex
17 EBI-717422,EBI-10244652 EPHA10  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.transmembrane-ephrin receptor activity
.ephrin receptor activity
.extracellular exosome
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
18 EBI-717422,EBI-9658404 IRAK1BP1  
  .I-kappaB kinase/NF-kappaB signaling
.immune response
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleus
19 EBI-717422,EBI-930143 CDC73  
  .negative regulation of G1/S transition of mitotic cell cycle
.cellular response to lipopolysaccharide
.negative regulation of epithelial cell proliferation
  + 17 more...
.RNA polymerase II core binding .Cdc73/Paf1 complex
.nucleoplasm
.nucleus
20 EBI-717422,EBI-748373 ZCCHC12  
  .BMP signaling pathway
.transcription, DNA-templated
.ligand-dependent nuclear receptor transcription coactivator activity
.zinc ion binding
.nucleic acid binding
.nuclear speck
21 EBI-717422,EBI-9679267 MOB3C  
  .N/A .metal ion binding .N/A
22 EBI-717422,EBI-10269715 NPEPL1  
  .N/A .manganese ion binding
.metalloexopeptidase activity
.aminopeptidase activity
.cytoplasm
.nucleus
23 EBI-717422,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
24 EBI-717422,EBI-2609717 ASAP3  
  .regulation of stress fiber assembly
.positive regulation of GTPase activity
.cell migration
.zinc ion binding
.GTPase activator activity
.focal adhesion
.cytoplasm
.ruffle
25 EBI-717422,EBI-714194 STMN2  
  .cellular response to nerve growth factor stimulus
.positive regulation of microtubule depolymerization
.negative regulation of microtubule polymerization
  + 3 more...
.calcium-dependent protein binding
.tubulin binding
.perinuclear region of cytoplasm
.neuronal cell body
.neuron projection
  + 8 more...
26 EBI-717422,EBI-2889252 NABP1  
  .response to ionizing radiation
.mitotic cell cycle checkpoint
.cellular response to DNA damage stimulus
  + 2 more...
.RNA binding
.single-stranded DNA binding
.SOSS complex
.cytoplasm
.nucleoplasm
.nucleus
27 EBI-717422,EBI-769261 EAF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .ELL-EAF complex
.nuclear speck
.Cajal body
  + 3 more...
28 EBI-717422,EBI-3906025 PPP3R2  
  .N/A .calcium ion binding .N/A
29 EBI-717422,EBI-2568609 FAM64A  
  .cell division
.mitotic nuclear division
.N/A .cytoplasm
.nucleolus
.nucleus
30 EBI-717422,EBI-2855862 POLR3GL  
  .innate immune response
.positive regulation of type I interferon production
.gene expression
  + 5 more...
.N/A .cytosol
.DNA-directed RNA polymerase III complex
.nucleoplasm
31 EBI-717422,EBI-10300345 CCDC94  
  .N/A .N/A .N/A
32 EBI-717422,EBI-10301451 TDRD1  
  .meiotic cell cycle
.DNA methylation involved in gamete generation
.piRNA metabolic process
  + 5 more...
.metal ion binding .pi-body
.P granule
.chromatoid body
.cytoplasm
33 EBI-717422,EBI-10303200 DPH1  
  .cellular protein metabolic process
.post-translational protein modification
.peptidyl-diphthamide biosynthetic process from peptidyl-histidine
.cell proliferation
.N/A .cytosol
.nucleus
34 EBI-717422,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
35 EBI-717422,EBI-1053902 MRPL40  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding .mitochondrial ribosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
36 EBI-717422,EBI-3396023 PLCB1  
  .positive regulation of CD24 biosynthetic process
.negative regulation of monocyte extravasation
.positive regulation of acrosome reaction
  + 30 more...
.protein homodimerization activity
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
  + 5 more...
.extracellular exosome
.nuclear membrane
.nuclear speck
  + 4 more...
37 EBI-717422,EBI-2859285 C19orf73  
  .N/A .N/A .N/A
38 EBI-717422,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
39 EBI-717422,EBI-10317544 DNAJC27  
  .regulation of MAPK export from nucleus
.positive regulation of ERK1 and ERK2 cascade
.Rab protein signal transduction
  + 2 more...
.GTP binding
.GTPase activity
.mitochondrion
.nucleus
40 EBI-717422,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
41 EBI-717422,EBI-722119 PPP1R1B  
  .regulation of catalytic activity
.negative regulation of catalytic activity
.intracellular signal transduction
  + 6 more...
.protein phosphatase type 1 regulator activity
.protein serine/threonine phosphatase inhibitor activity
.protein phosphatase inhibitor activity
.protein kinase inhibitor activity
.neuronal cell body
.cytosol
.cytoplasm
.nucleus
42 EBI-717422,EBI-10320535 DNAJC5B  
  .N/A .N/A .membrane
43 EBI-717422,EBI-10320765 POLL  
  .somatic hypermutation of immunoglobulin genes
.nucleotide-excision repair
.DNA replication
.metal ion binding
.lyase activity
.DNA-directed DNA polymerase activity
.DNA binding
.nucleus
44 EBI-717422,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites75
bladder33
blood57
bone69
bone marrow41
brain60
cervix61
connective tissue87
embryonic tissue61
esophagus49
eye67
heart100
intestine60
kidney37
liver24
lung29
lymph22
lymph node55
mammary gland26
mouth75
muscle37
ovary59
pharynx24
pituitary gland60
placenta21
prostate31
skin28
spleen74
stomach41
testis64
thymus50
thyroid64
trachea96
uterus60
Health State
TissuesTPM*
normal45
adrenal tumor79
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma96
colorectal tumor44
esophageal tumor57
gastrointestinal tumor50
germ cell tumor140
glioma55
head and neck tumor67
kidney tumor29
leukemia74
liver tumor52
lung tumor9
lymphoma55
non-neoplasia51
ovarian tumor78
primitive neuroectodermal tumor of the CNS15
prostate cancer9
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor39
uterine tumor77
Developmental Stage
TissuesTPM*
adult68
embryoid body28
blastocyst65
neonate64
fetus62
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.1
adrenal gland13.8
appendix21.3
bone marrow7
cerebral cortex19.1
colon18.8
duodenum13.9
esophagus16
gallbladder17
heart muscle16.1
kidney14.9
liver7.7
lung13.7
lymph node23.4
ovary19.2
pancreas7.3
placenta18.8
prostate18.1
salivary gland12.8
skin14.1
small intestine15.4
spleen18.9
stomach15.3
testis11.1
thyroid gland19
urinary bladder19.9
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*189889, gene) Transcription factor cp2; TFCP2OMIM


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