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> Protein (NX_Q12841)
Protein (NX_Q12841)
Protein
Gene SymbolFSTL1 to neXtProt (NX_Q12841)
DescriptionFollistatin-related protein 1
Chromosome3
Location3q13.33 (120111140 ~ 120170100) to Ensembl
Sequene Features : Isoforms 2, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to starvation
.BMP signaling pathway
.heparin binding
.calcium ion binding
.extracellular exosome
.extracellular space
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 41 6
2014-09-19protein level
2 35 6
2014-05-27protein level
1 35 6
2014-02-25protein level
1 36 6
2013-12-09protein level
1 27 6
2013-11-01protein level
1 27 6
2013-09-12protein level
1 27 6
2013-08-17protein level
1 27 6
2013-07-15protein level
1 21 6
2013-06-11protein level
1 21 6
2013-02-12protein level
1 8 6
2012-12-20protein level
1 8 6
2012-10-30protein level
1 12 6
2012-10-07protein level
1 12 6
2012-08-24protein level
1 7 6
2012-07-28protein level
1 7 6
2012-06-08protein level
1 7 6
2012-05-07protein level
1 7 6
2012-04-10protein level
1 7 6
2012-01-13protein level
1 1 6
2011-12-20protein level
1 1 6
2011-11-11protein level
1 1 6
2011-08-23protein level
1 1 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12841-1
2 17 0 34962.7628
NX_Q12841-2
1 17 0 31208.0123
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2349801,EBI-779636 TGFB1  
  .positive regulation of transcription regulatory region DNA binding
.regulation of actin cytoskeleton reorganization
.positive regulation of NAD+ ADP-ribosyltransferase activity
  + 151 more...
.type III transforming growth factor beta receptor binding
.type I transforming growth factor beta receptor binding
.enzyme binding
  + 4 more...
.blood microparticle
.neuronal cell body
.platelet alpha granule lumen
  + 9 more...
2 EBI-2349801,EBI-3905196 CD14  
  .activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
.cellular response to lipoteichoic acid
  + 25 more...
.lipoteichoic acid binding
.peptidoglycan receptor activity
.opsonin receptor activity
.lipopolysaccharide binding
.extracellular exosome
.membrane raft
.anchored component of membrane
  + 5 more...
3 EBI-2349801,EBI-1029262 BMP2  
  .negative regulation of cardiac muscle cell differentiation
.negative regulation of cortisol biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
  + 81 more...
.BMP receptor binding
.protein heterodimerization activity
.SMAD binding
  + 5 more...
.cell surface
.extracellular space
.extracellular region
4 EBI-2349801,EBI-2564275 DIP2A  
  .regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
5 EBI-2349801,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue932
adrenal gland182
ascites25
bladder167
bone698
bone marrow246
brain161
cervix82
connective tissue952
ear559
embryonic tissue1033
esophagus49
eye210
heart804
intestine51
kidney270
larynx1747
liver126
lung146
lymph node11
mammary gland92
mouth786
muscle423
nerve386
ovary147
pancreas154
parathyroid97
pharynx98
placenta809
prostate221
salivary gland98
skin374
spleen74
stomach240
testis335
thymus326
thyroid815
trachea1796
umbilical cord435
uterus973
vascular735
Health State
TissuesTPM*
normal343
adrenal tumor316
bladder carcinoma113
breast (mammary gland) tumor42
cervical tumor115
chondrosarcoma688
colorectal tumor44
esophageal tumor57
gastrointestinal tumor151
germ cell tumor562
glioma121
head and neck tumor792
kidney tumor304
liver tumor124
lung tumor97
lymphoma13
non-neoplasia807
ovarian tumor157
pancreatic tumor257
primitive neuroectodermal tumor of the CNS94
prostate cancer192
skin tumor87
soft tissue/muscle tissue tumor79
uterine tumor255
Developmental Stage
TissuesTPM*
adult375
embryoid body1715
blastocyst781
neonate450
fetus310
infant85
juvenile215
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue321.2
adrenal gland126.5
appendix108.8
bone marrow1.5
cerebral cortex16.6
colon93.6
duodenum29.6
esophagus111.7
gallbladder258.1
heart muscle185.4
kidney39.9
liver21.7
lung78.4
lymph node49.9
ovary87.3
pancreas15.7
placenta363.2
prostate176.5
salivary gland24.3
skin29.9
small intestine49.5
spleen60.4
stomach35.9
testis45.3
thyroid gland48.5
urinary bladder264.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605547, gene) Follistatin-like 1; FSTL1OMIM


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