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> Protein (NX_Q12846)
Protein (NX_Q12846)
Protein
Gene SymbolSTX4 to neXtProt (NX_Q12846)
DescriptionSyntaxin-4
Chromosome16
Location16p11.2 (31044210 ~ 31054296) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 11
2014-09-19protein level
2 27 11
2014-05-27protein level
2 27 11
2014-02-25protein level
1 26 11
2013-12-09protein level
1 23 11
2013-11-01protein level
1 22 9
2013-09-12protein level
1 22 8
2013-08-17protein level
1 22 8
2013-07-15protein level
1 9 6
2013-06-11protein level
1 9 6
2013-02-12protein level
1 6 6
2012-12-20protein level
1 6 6
2012-10-30protein level
1 8 6
2012-10-07protein level
1 8 6
2012-08-24protein level
1 7 6
2012-07-28protein level
1 7 6
2012-06-08protein level
1 9 6
2012-05-07protein level
1 7 6
2012-04-10protein level
1 7 6
2012-01-13protein level
1 3 6
2011-12-20protein level
1 3 6
2011-11-11protein level
1 3 5
2011-08-23protein level
1 3 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12846-1
3 10 0 34158.7537
NX_Q12846-2
1 10 0 33819.6832
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744942,EBI-4401517 GOSR2  
  .membrane fusion
.vesicle fusion with Golgi apparatus
.cellular protein metabolic process
  + 7 more...
.SNAP receptor activity
.transporter activity
.SNARE binding
.late endosome membrane
.SNARE complex
.integral component of membrane
  + 5 more...
2 EBI-744942,EBI-2853548 STX16  
  .Golgi ribbon formation
.vesicle docking
.retrograde transport, endosome to Golgi
  + 3 more...
.syntaxin binding
.SNAP receptor activity
.SNARE binding
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.Golgi cisterna
  + 11 more...
3 EBI-744942,EBI-749204 BET1  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.N/A .Golgi cisterna
.integral component of membrane
.membrane
  + 3 more...
4 EBI-744942,EBI-3221827 STX7  
  .regulation of protein localization to plasma membrane
.positive regulation of receptor localization to synapse
.organelle assembly
  + 5 more...
.syntaxin binding
.chloride channel inhibitor activity
.SNAP receptor activity
.SNARE binding
.tertiary granule
.extracellular exosome
.recycling endosome
  + 16 more...
5 EBI-744942,EBI-2695795 STX6  
  .Golgi ribbon formation
.Golgi vesicle transport
.retrograde transport, endosome to Golgi
  + 4 more...
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.trans-Golgi network membrane
.SNARE complex
  + 6 more...
6 EBI-744942,EBI-744953 VAMP4  
  .Golgi ribbon formation
.regulation of Golgi to plasma membrane protein transport
.SNARE complex assembly
  + 2 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.cell surface
  + 5 more...
7 EBI-744942,EBI-10191195 VAMP5  
  .Golgi to plasma membrane protein transport
.cell differentiation
.skeletal muscle tissue development
  + 4 more...
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.integral component of organelle membrane
  + 9 more...
8 EBI-744942,EBI-10201335 VAMP1  
  .SNARE complex assembly
.vesicle fusion
.exocytosis
.SNAP receptor activity
.SNARE binding
.tertiary granule membrane
.neuron projection
.specific granule membrane
  + 8 more...
9 EBI-744942,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
10 EBI-744942,EBI-749652 NAPA  
  .membrane fusion
.membrane organization
.apical protein localization
  + 8 more...
.syntaxin binding
.soluble NSF attachment protein activity
.extracellular exosome
.synaptobrevin 2-SNAP-25-syntaxin-1a complex
.SNARE complex
  + 3 more...
11 EBI-744942,EBI-520113 VAMP2  
  .positive regulation of intracellular protein transport
.membrane fusion
.membrane organization
  + 22 more...
.calcium-dependent protein binding
.protein self-association
.syntaxin binding
  + 5 more...
.clathrin-sculpted monoamine transport vesicle membrane
.extracellular exosome
.synaptobrevin 2-SNAP-25-syntaxin-1a complex
  + 23 more...
12 EBI-744942,EBI-714206 STX5  
  .regulation of Golgi organization
.Golgi disassembly
.vesicle fusion with Golgi apparatus
  + 7 more...
.protein N-terminus binding
.SNAP receptor activity
.SNARE binding
.endoplasmic reticulum-Golgi intermediate compartment membrane
.vesicle
.SNARE complex
  + 5 more...
13 EBI-744942,EBI-1394295 STX3  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.long-term synaptic potentiation
  + 7 more...
.arachidonic acid binding
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.neuron projection
.azurophil granule
  + 11 more...
14 EBI-744942,EBI-722343 VAMP3  
  .negative regulation of secretion by cell
.membrane fusion
.Golgi to plasma membrane protein transport
  + 11 more...
.SNAP receptor activity
.SNARE binding
.recycling endosome
.intracellular membrane-bounded organelle
.neuron projection
  + 12 more...
15 EBI-744942,EBI-8637742 CYBRD1  
  .transmembrane transport
.response to iron ion
.cellular iron ion homeostasis
.metal ion binding
.oxidoreductase activity, oxidizing metal ions
.ferric-chelate reductase activity
.extracellular exosome
.brush border membrane
.integral component of membrane
.plasma membrane
16 EBI-744942,EBI-10244848 SNAP47  
  .long-term synaptic potentiation
.synaptic vesicle fusion to presynaptic membrane
.synaptic vesicle priming
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.neuronal cell body
.SNARE complex
  + 3 more...
17 EBI-744942,EBI-2691717 STX12  
  .protein stabilization
.vesicle docking
.cholesterol efflux
  + 2 more...
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.phagocytic vesicle
.membrane raft
  + 5 more...
18 EBI-744942,EBI-6166686 GIMAP5  
  .negative regulation of lipid catabolic process
.negative regulation of T cell activation
.regulation of mitochondrial membrane permeability
  + 14 more...
.GTP binding .integral component of membrane
.lysosome
.mitochondrial outer membrane
19 EBI-744942,EBI-8652744 SEC22A  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.SNAP receptor activity
.transporter activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endoplasmic reticulum membrane
20 EBI-744942,EBI-3921185 NAPB  
  .membrane fusion
.SNARE complex disassembly
.intracellular protein transport
.syntaxin binding
.soluble NSF attachment protein activity
.extracellular exosome
.SNARE complex
.vacuolar membrane
21 EBI-744942,EBI-723716 VTI1B  
  .regulation of protein localization to plasma membrane
.membrane fusion
.vesicle fusion with Golgi apparatus
  + 8 more...
.chloride channel inhibitor activity
.SNAP receptor activity
.SNARE binding
.recycling endosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 11 more...
22 EBI-744942,EBI-727240 STX8  
  .regulation of protein localization to plasma membrane
.early endosome to late endosome transport
.endosome to lysosome transport
  + 3 more...
.syntaxin binding
.chloride channel inhibitor activity
.SNAP receptor activity
.recycling endosome
.perinuclear region of cytoplasm
.vesicle
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood81
bone97
brain23
cervix61
connective tissue20
embryonic tissue42
esophagus49
eye38
heart11
intestine51
kidney28
larynx426
liver38
lung95
lymph22
lymph node22
mammary gland19
muscle18
nerve64
ovary59
pancreas32
pharynx24
pituitary gland60
placenta14
prostate68
skin37
spleen37
stomach31
testis13
thymus50
thyroid64
uterus51
Health State
TissuesTPM*
normal31
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma84
colorectal tumor35
esophageal tumor57
gastrointestinal tumor59
germ cell tumor15
glioma46
head and neck tumor97
kidney tumor29
leukemia42
liver tumor20
lung tumor87
lymphoma13
non-neoplasia10
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer57
retinoblastoma21
skin tumor63
soft tissue/muscle tissue tumor119
uterine tumor55
Developmental Stage
TissuesTPM*
adult54
embryoid body71
blastocyst16
neonate64
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.1
adrenal gland51.4
appendix45.8
bone marrow39.4
cerebral cortex26
colon32.2
duodenum42.1
esophagus27.7
gallbladder40
heart muscle25.2
kidney26
liver24.1
lung42.8
lymph node41.5
ovary27.6
pancreas14.1
placenta35
prostate29.8
salivary gland25.7
skin56.2
small intestine38.9
spleen56.8
stomach37.5
testis18.1
thyroid gland26.4
urinary bladder33.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*186591, gene) Syntaxin 4; STX4OMIM


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