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> Protein (NX_Q12851)
Protein (NX_Q12851)
Protein
Gene SymbolMAP4K2 to neXtProt (NX_Q12851)
DescriptionMitogen-activated protein kinase kinase kinase kinase 2
Chromosome11
Location11q13.1 (64556290 ~ 64570713) to Ensembl
Sequene Features : Isoforms 2, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of JNK cascade
.innate immune response
.regulation of apoptotic process
  + 8 more...
.mitogen-activated protein kinase kinase kinase binding
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.basolateral plasma membrane
.Golgi membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 76 3
2014-09-19protein level
2 59 3
2014-05-27protein level
2 58 3
2014-02-25protein level
1 59 3
2013-12-09protein level
1 34 3
2013-11-01protein level
1 34 3
2013-09-12protein level
1 34 3
2013-08-17protein level
1 34 3
2013-07-15protein level
1 19 2
2013-06-11protein level
1 19 2
2013-02-12protein level
1 11 5
2012-12-20protein level
1 11 5
2012-10-30protein level
1 14 5
2012-10-07protein level
1 14 5
2012-08-24protein level
1 9 5
2012-07-28protein level
1 8 5
2012-06-08protein level
1 9 5
2012-05-07protein level
1 9 5
2012-04-10protein level
1 9 5
2012-01-13protein level
1 7 5
2011-12-20protein level
1 7 5
2011-11-11protein level
1 7 5
2011-08-23protein level
1 7 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12851-1
1 34 2 91497.8291
NX_Q12851-2
1 34 2 90751.4349
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-49783,EBI-49776 MAP3K1  
  .cellular response to mechanical stimulus
.eyelid development in camera-type eye
.stress-activated MAPK cascade
  + 21 more...
.protein kinase binding
.JUN kinase kinase activity
.zinc ion binding
  + 3 more...
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood89
bone marrow512
brain10
cervix20
embryonic tissue4
eye38
heart22
intestine12
kidney37
larynx42
liver4
lung29
lymph22
lymph node122
mammary gland13
muscle47
ovary9
pancreas18
placenta49
prostate68
skin4
spleen56
thymus12
tonsil117
uterus25
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma24
germ cell tumor22
glioma9
head and neck tumor7
kidney tumor29
leukemia391
liver tumor10
lymphoma41
pancreatic tumor38
prostate cancer105
retinoblastoma21
soft tissue/muscle tissue tumor55
uterine tumor22
Developmental Stage
TissuesTPM*
adult38
embryoid body14
neonate32
fetus19
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8
adrenal gland6.4
appendix16.3
bone marrow18.4
cerebral cortex8.9
colon5.4
duodenum6.5
esophagus4.1
gallbladder7.7
heart muscle5.5
kidney6.9
liver2.6
lung17.3
lymph node30.3
ovary4.6
pancreas4.3
placenta15.5
prostate6.8
salivary gland8
skin4.7
small intestine5.5
spleen31.6
stomach8.2
testis8.6
thyroid gland10.2
urinary bladder8.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasLow
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603166, gene) Mitogen-activated protein kinase kinase kinase kinase 2; MAP4K2OMIM


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