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> Protein (NX_Q12873)
Protein (NX_Q12873)
Protein
Gene SymbolCHD3 to neXtProt (NX_Q12873)
DescriptionChromodomain-helicase-DNA-binding protein 3
Chromosome17
Location17p13.1 (7788124 ~ 7816078) to Ensembl
Sequene Features : Isoforms 3, Variants 196, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.centrosome organization
.DNA duplex unwinding
.chromatin modification
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.ATP binding
  + 3 more...
.intermediate filament cytoskeleton
.NuRD complex
.centrosome
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 196 9
2014-09-19protein level
3 138 9
2014-05-27protein level
3 138 10
2014-02-25protein level
3 138 10
2013-12-09protein level
3 116 10
2013-11-01protein level
3 114 9
2013-09-12protein level
3 114 9
2013-08-17protein level
3 114 9
2013-07-15protein level
2 72 9
2013-06-11protein level
2 72 9
2013-02-12protein level
2 27 20
2012-12-20protein level
2 27 20
2012-10-30protein level
2 27 20
2012-10-07protein level
2 27 10
2012-08-24protein level
2 22 10
2012-07-28protein level
2 22 10
2012-06-08protein level
2 27 10
2012-05-07protein level
2 16 10
2012-04-10protein level
2 16 10
2012-01-13protein level
2 15 10
2011-12-20protein level
2 15 10
2011-11-11protein level
2 15 9
2011-08-23protein level
2 15 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12873-1
0 67 22 226448.8893
NX_Q12873-2
0 64 22 222720.1262
NX_Q12873-3
2 65 22 232890.3562
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-523590,EBI-710124 KDM1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
2 EBI-523590,EBI-473291 PRPF40A  
  .cell division
.regulation of cytokinesis
.cell migration
  + 5 more...
.poly(A) RNA binding .nuclear speck
.nuclear matrix
.membrane
  + 2 more...
3 EBI-523590,EBI-351962 DDX5  
  .regulation of skeletal muscle cell differentiation
.intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of androgen receptor signaling pathway
  + 13 more...
.androgen receptor binding
.poly(A) RNA binding
.pre-mRNA binding
  + 5 more...
.catalytic step 2 spliceosome
.extracellular exosome
.ribonucleoprotein complex
  + 5 more...
4 EBI-523590,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
5 EBI-523590,EBI-473220 SUMO2  
  .positive regulation of transcription from RNA polymerase II promoter
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.PML body
.nucleoplasm
.nucleus
6 EBI-523590,EBI-523558 SERBP1  
  .regulation of mRNA stability
.regulation of apoptotic process
.poly(A) RNA binding
.mRNA 3'-UTR binding
.extracellular exosome
.perinuclear region of cytoplasm
.membrane
  + 3 more...
7 EBI-523590,EBI-473181 BARD1  
  .protein K6-linked ubiquitination
.negative regulation of protein export from nucleus
.positive regulation of protein catabolic process
  + 9 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase binding
  + 4 more...
.BRCA1-A complex
.intracellular membrane-bounded organelle
.BRCA1-BARD1 complex
  + 5 more...
8 EBI-523590,EBI-466061 GIT1  
  .ephrin receptor signaling pathway
.regulation of cytokinesis
.regulation of G-protein coupled receptor protein signaling pathway
.axon guidance
.zinc ion binding
.GTPase activator activity
.aggresome
.membrane
.focal adhesion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
bladder66
blood89
bone125
brain140
cervix103
connective tissue46
embryonic tissue112
esophagus148
eye134
heart67
intestine94
kidney52
larynx426
liver77
lung143
lymph361
lymph node356
mammary gland132
mouth332
muscle37
nerve193
ovary68
pancreas98
pharynx24
pituitary gland60
placenta24
prostate184
skin56
spleen18
stomach94
testis36
thymus276
thyroid193
trachea77
umbilical cord72
uterus107
vascular58
Health State
TissuesTPM*
normal100
bladder carcinoma170
breast (mammary gland) tumor182
cervical tumor144
chondrosarcoma96
colorectal tumor151
esophageal tumor173
gastrointestinal tumor75
germ cell tumor83
glioma102
head and neck tumor246
kidney tumor116
leukemia137
liver tumor72
lung tumor262
lymphoma263
non-neoplasia93
ovarian tumor65
pancreatic tumor95
primitive neuroectodermal tumor of the CNS70
prostate cancer154
retinoblastoma86
skin tumor55
soft tissue/muscle tissue tumor31
uterine tumor144
Developmental Stage
TissuesTPM*
adult111
embryoid body128
blastocyst16
neonate64
fetus165
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.8
adrenal gland28.6
appendix44.6
bone marrow40.1
cerebral cortex42.9
colon26
duodenum16.5
esophagus27.2
gallbladder36.4
heart muscle10.6
kidney26.9
liver4.1
lung36.6
lymph node56.9
ovary41.9
pancreas15.2
placenta20.5
prostate62.4
salivary gland35.2
skin42.8
small intestine22
spleen45.1
stomach27.2
testis28
thyroid gland30.6
urinary bladder43.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602120, gene) Chromodomain helicase dna-binding protein 3; CHD3OMIM


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