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> Protein (NX_Q12888)
Protein (NX_Q12888)
Protein
Gene SymbolTP53BP1 to neXtProt (NX_Q12888)
DescriptionTumor suppressor p53-binding protein 1
Chromosome15
Location15q15.3 (43699407 ~ 43802926) to Ensembl
Sequene Features : Isoforms 3, Variants 229, PTMs 91 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 5 more...
.telomeric DNA binding
.methylated histone binding
.damaged DNA binding
  + 3 more...
.cytoplasm
.replication fork
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 229 91
2014-09-19protein level
3 173 92
2014-05-27protein level
2 173 92
2014-02-25protein level
2 172 92
2013-12-09protein level
2 135 92
2013-11-01protein level
2 127 91
2013-09-12protein level
2 127 89
2013-08-17protein level
2 127 89
2013-07-15protein level
2 99 89
2013-06-11protein level
2 99 89
2013-02-12protein level
2 65 218
2012-12-20protein level
2 62 218
2012-10-30protein level
2 74 218
2012-10-07protein level
2 74 109
2012-08-24protein level
2 48 109
2012-07-28protein level
2 48 109
2012-06-08protein level
2 73 109
2012-05-07protein level
2 73 109
2012-04-10protein level
2 73 109
2012-01-13protein level
2 58 109
2011-12-20protein level
2 58 109
2011-11-11protein level
2 58 98
2011-08-23protein level
2 58 98
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12888-1
1 90 0 213442.089
NX_Q12888-2
0 91 0 213984.3035
NX_Q12888-3
1 90 0 213856.2453
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396540,EBI-347522 ZNHIT1  
  .negative regulation of G0 to G1 transition
.histone exchange
.regulation of T cell proliferation
  + 2 more...
.metal ion binding
.histone deacetylase binding
.nucleosome binding
.nucleus
.Swr1 complex
2 EBI-396540,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-396540,EBI-302023 HIST2H4A  
  .protein heterotetramerization
.negative regulation of gene expression, epigenetic
.negative regulation of megakaryocyte differentiation
  + 13 more...
.poly(A) RNA binding
.histone binding
.histone demethylase activity (H4-K20 specific)
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 5 more...
4 EBI-396540,EBI-79722 HIST1H3A  
  .regulation of gene silencing
.protein heterotetramerization
.negative regulation of gene expression, epigenetic
  + 10 more...
.histone binding
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 6 more...
5 EBI-396540,EBI-2107455 VAC14  
  .small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
6 EBI-396540,EBI-743225 PAXIP1  
  .chorion development
.adipose tissue development
.positive regulation of transcription initiation from RNA polymerase II promoter
  + 13 more...
.N/A .histone methyltransferase complex
.nuclear matrix
.nucleus
7 EBI-396540,EBI-1769146 VRK1  
  .Golgi disassembly
.histone H3-T3 phosphorylation
.cell division
  + 10 more...
.histone kinase activity (H3-T3 specific)
.histone kinase activity (H3-S10 specific)
.nucleosomal histone binding
  + 4 more...
.cytosol
.spindle
.Golgi stack
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
bladder33
blood32
bone27
bone marrow82
brain53
cervix61
connective tissue53
embryonic tissue93
esophagus49
eye47
heart78
intestine38
kidney18
larynx213
liver19
lung50
lymph node22
mammary gland244
mouth30
muscle56
ovary118
pancreas32
parathyroid48
placenta38
prostate84
salivary gland49
skin118
spleen56
testis43
thymus50
thyroid128
tonsil117
trachea77
uterus99
Health State
TissuesTPM*
normal48
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma24
colorectal tumor35
esophageal tumor57
gastrointestinal tumor42
germ cell tumor30
glioma18
head and neck tumor104
kidney tumor14
leukemia21
liver tumor31
lung tumor58
ovarian tumor118
pancreatic tumor38
primitive neuroectodermal tumor of the CNS47
prostate cancer125
skin tumor167
soft tissue/muscle tissue tumor55
uterine tumor122
Developmental Stage
TissuesTPM*
adult72
embryoid body28
blastocyst16
neonate32
fetus46
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.1
adrenal gland15.5
appendix13.5
bone marrow9.6
cerebral cortex19.8
colon10.9
duodenum5.6
esophagus8.3
gallbladder16.6
heart muscle8.9
kidney10.7
liver3.3
lung10.4
lymph node12.5
ovary21.7
pancreas4.1
placenta13.2
prostate15.6
salivary gland10
skin10.8
small intestine6
spleen11.4
stomach11.2
testis24.2
thyroid gland23.5
urinary bladder16.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605230, gene) Tumor protein p53-binding protein 1; TP53BP1OMIM


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