Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q12913)
Protein (NX_Q12913)
Protein
Gene SymbolPTPRJ to neXtProt (NX_Q12913)
DescriptionReceptor-type tyrosine-protein phosphatase eta
Chromosome11
Location11p11.2 (48002113 ~ 48189670) to Ensembl
Sequene Features : Isoforms 2, Variants 208, PTMs 36 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 208 36
2014-09-19protein level
2 159 36
2014-05-27protein level
2 159 36
2014-02-25protein level
2 157 36
2013-12-09protein level
2 123 36
2013-11-01protein level
2 116 36
2013-09-12protein level
2 116 36
2013-08-17protein level
2 116 36
2013-07-15protein level
2 81 36
2013-06-11protein level
2 81 36
2013-02-12protein level
2 51 56
2012-12-20protein level
2 46 56
2012-10-30protein level
2 65 56
2012-10-07protein level
2 65 36
2012-08-24protein level
2 63 36
2012-07-28protein level
2 63 36
2012-06-08protein level
2 71 36
2012-05-07protein level
2 56 36
2012-04-10protein level
1 56 36
2012-01-13protein level
1 29 36
2011-12-20protein level
1 29 36
2011-11-11protein level
1 29 35
2011-08-23protein level
1 29 35
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12913-1
36 24 0 145850.2694
NX_Q12913-2
0 24 0 57154.6854
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2264500,EBI-701927 CTNND1  
  .negative regulation of canonical Wnt signaling pathway
.vascular endothelial growth factor receptor signaling pathway
.cell-cell junction organization
  + 8 more...
.cadherin binding
.receptor binding
.extracellular exosome
.synapse
.dendritic spine
  + 9 more...
2 EBI-2264500,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-2264500,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
4 EBI-2264500,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
5 EBI-2264500,EBI-286316 GHR  
  .JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.positive regulation of peptidyl-tyrosine phosphorylation
  + 25 more...
.proline-rich region binding
.protein homodimerization activity
.protein kinase binding
  + 3 more...
.growth hormone receptor complex
.receptor complex
.integral component of membrane
  + 5 more...
6 EBI-2264500,EBI-1026718 FLT1  
  .embryonic morphogenesis
.blood vessel morphogenesis
.vascular endothelial growth factor receptor signaling pathway
  + 20 more...
.placental growth factor-activated receptor activity
.VEGF-B-activated receptor activity
.VEGF-A-activated receptor activity
  + 4 more...
.receptor complex
.focal adhesion
.integral component of plasma membrane
  + 3 more...
7 EBI-2264500,EBI-73995 MAPK3  
  .negative regulation of apolipoprotein binding
.regulation of early endosome to late endosome transport
.regulation of cellular response to heat
  + 62 more...
.phosphatase binding
.ATP binding
.MAP kinase activity
.extracellular exosome
.pseudopodium
.microtubule cytoskeleton
  + 11 more...
8 EBI-2264500,EBI-959949 MAPK1  
  .regulation of early endosome to late endosome transport
.regulation of cellular response to heat
.cellular response to granulocyte macrophage colony-stimulating factor stimulus
  + 70 more...
.phosphatase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.protein complex
  + 17 more...
9 EBI-2264500,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
10 EBI-2264500,EBI-1005487 KDR  
  .positive regulation of vasculogenesis
.negative regulation of endothelial cell apoptotic process
.positive regulation of ERK1 and ERK2 cascade
  + 39 more...
.Hsp90 protein binding
.vascular endothelial growth factor binding
.growth factor binding
  + 6 more...
.sorting endosome
.membrane raft
.cell junction
  + 10 more...
11 EBI-2264500,EBI-3946257 FLT3  
  .dendritic cell differentiation
.cellular response to glucocorticoid stimulus
.cellular response to cytokine stimulus
  + 24 more...
.protein homodimerization activity
.ATP binding
.vascular endothelial growth factor-activated receptor activity
  + 2 more...
.protein complex
.external side of plasma membrane
.integral component of plasma membrane
  + 3 more...
12 EBI-2264500,EBI-2257090 TEK  
  .negative regulation of endothelial cell apoptotic process
.regulation of endothelial cell apoptotic process
.positive regulation of actin cytoskeleton reorganization
  + 45 more...
.ATP binding
.receptor activity
.transmembrane receptor protein tyrosine kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.membrane raft
.apical plasma membrane
  + 10 more...
13 EBI-2264500,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood65
bone69
brain17
connective tissue6
embryonic tissue4
eye33
heart33
intestine25
kidney85
liver24
lung14
lymph node11
mammary gland26
mouth15
pancreas46
placenta31
prostate21
skin37
stomach73
testis9
thyroid42
tonsil58
trachea19
uterus25
Health State
TissuesTPM*
normal24
breast (mammary gland) tumor32
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor67
germ cell tumor7
glioma18
head and neck tumor7
kidney tumor29
leukemia201
liver tumor20
lung tumor9
non-neoplasia10
pancreatic tumor57
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult32
embryoid body14
neonate32
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.6
adrenal gland2.8
appendix19.1
bone marrow16.4
cerebral cortex8.8
colon10.1
duodenum7.7
esophagus2
gallbladder7.6
heart muscle2
kidney12.1
liver4.8
lung7.4
lymph node13.4
ovary1.7
pancreas2.9
placenta8.7
prostate5.4
salivary gland6.5
skin2.4
small intestine12.2
spleen17.5
stomach12.1
testis2.6
thyroid gland20.6
urinary bladder7.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineLow
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverHigh
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600925, gene) Protein-tyrosine phosphatase, receptor-type, j; PTPRJOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center