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> Protein (NX_Q12923)
Protein (NX_Q12923)
Protein
Gene SymbolPTPN13 to neXtProt (NX_Q12923)
DescriptionTyrosine-protein phosphatase non-receptor type 13
Chromosome4
Location4q21.3 (87515468 ~ 87736324) to Ensembl
Sequene Features : Isoforms 4, Variants 271, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-tyrosine dephosphorylation
.regulation of phosphatidylinositol 3-kinase signaling
.protein dephosphorylation
.phosphatidylinositol 3-kinase regulatory subunit binding
.protein tyrosine phosphatase activity
.extracellular exosome
.cell body
.neuron projection
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 271 13
2014-09-19protein level
4 212 13
2014-05-27protein level
4 212 13
2014-02-25protein level
4 211 13
2013-12-09protein level
4 142 13
2013-11-01protein level
4 140 13
2013-09-12protein level
4 140 14
2013-08-17protein level
4 140 14
2013-07-15protein level
4 92 14
2013-06-11protein level
4 92 14
2013-02-12protein level
4 45 39
2012-12-20protein level
4 44 39
2012-10-30protein level
4 66 39
2012-10-07protein level
4 66 13
2012-08-24protein level
4 62 13
2012-07-28protein level
4 62 13
2012-06-08protein level
4 87 13
2012-05-07protein level
4 72 13
2012-04-10protein level
4 72 13
2012-01-13protein level
4 57 13
2011-12-20protein level
4 57 13
2011-11-11protein level
4 57 13
2011-08-23protein level
4 57 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12923-1
0 121 0 276731.9465
NX_Q12923-2
1 111 0 255765.4474
NX_Q12923-3
1 120 0 274760.0741
NX_Q12923-4
2 120 0 277334.2876
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355227,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
2 EBI-355227,EBI-2693017 RAPGEF6  
  .protein localization to plasma membrane
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 2 more...
.phosphatidic acid binding
.GTP-dependent protein binding
.Ras GTPase binding
.guanyl-nucleotide exchange factor activity
.endocytic vesicle
.apical plasma membrane
.plasma membrane
.cytosol
3 EBI-355227,EBI-740195 PDCD10  
  .negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
.Golgi reassembly
.negative regulation of cell migration involved in sprouting angiogenesis
  + 16 more...
.protein N-terminus binding
.protein homodimerization activity
.protein kinase binding
.extracellular exosome
.plasma membrane
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
bone139
brain26
cervix20
connective tissue107
ear310
embryonic tissue131
eye114
intestine8
kidney80
larynx127
lung14
lymph node11
mammary gland13
mouth60
muscle75
pancreas23
pharynx24
pituitary gland242
placenta10
prostate31
skin4
testis32
thyroid21
trachea38
uterus34
Health State
TissuesTPM*
normal39
bladder carcinoma284
cervical tumor28
chondrosarcoma48
colorectal tumor8
germ cell tumor26
glioma37
head and neck tumor52
kidney tumor29
lymphoma13
non-neoplasia41
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer28
retinoblastoma172
soft tissue/muscle tissue tumor127
uterine tumor22
Developmental Stage
TissuesTPM*
adult40
embryoid body157
blastocyst113
fetus43
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.2
adrenal gland7.1
appendix3.6
cerebral cortex9.5
colon3.2
esophagus25.6
gallbladder8.5
heart muscle4.1
kidney23.6
lung21
lymph node5.2
ovary27.7
pancreas2.6
placenta2.9
prostate11.9
salivary gland1.5
skin46.1
small intestine1.2
spleen3.9
stomach3
testis16.4
thyroid gland20.7
urinary bladder22.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skin 1Low
skin 2High
small intestineHigh
soft tissue 1Low
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandLow
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600267, gene) Protein-tyrosine phosphatase, nonreceptor-type, 13; PTPN13OMIM


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