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> Protein (NX_Q12929)
Protein (NX_Q12929)
Protein
Gene SymbolEPS8 to neXtProt (NX_Q12929)
DescriptionEpidermal growth factor receptor kinase substrate 8
Chromosome12
Location12p12.3 (15773092 ~ 16035263) to Ensembl
Sequene Features : Isoforms 2, Variants 113, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 113 8
2014-09-19protein level
1 89 8
2014-05-27protein level
1 89 8
2014-02-25protein level
1 88 8
2013-12-09protein level
1 64 8
2013-11-01protein level
1 60 8
2013-09-12protein level
1 60 8
2013-08-17protein level
1 60 8
2013-07-15protein level
1 45 8
2013-06-11protein level
1 45 8
2013-02-12protein level
1 32 8
2012-12-20protein level
1 32 8
2012-10-30protein level
1 35 8
2012-10-07protein level
1 35 8
2012-08-24protein level
1 20 8
2012-07-28protein level
1 20 8
2012-06-08protein level
1 21 8
2012-05-07protein level
1 21 8
2012-04-10protein level
1 21 8
2012-01-13protein level
1 21 8
2011-12-20protein level
1 21 8
2011-11-11protein level
1 21 8
2011-08-23protein level
1 21 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12929-1
13 25 0 91824.161
NX_Q12929-2
0 25 0 62831.9878
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-375576,EBI-1215506 CASK  
  .negative regulation of cellular response to growth factor stimulus
.positive regulation of calcium ion import
.calcium ion import
  + 9 more...
.ATP binding
.protein serine/threonine kinase activity
.guanylate kinase activity
.ciliary membrane
.presynaptic membrane
.nuclear matrix
  + 10 more...
2 EBI-375576,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-375576,EBI-357966 HNRNPC  
  .3'-UTR-mediated mRNA stabilization
.ATP-dependent chromatin remodeling
.gene expression
  + 3 more...
.N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.identical protein binding
  + 7 more...
.catalytic step 2 spliceosome
.extracellular exosome
.protein complex
  + 6 more...
4 EBI-375576,EBI-726842 ALDH7A1  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.glycine betaine biosynthetic process from choline
  + 3 more...
.betaine-aldehyde dehydrogenase activity
.L-aminoadipate-semialdehyde dehydrogenase activity
.aldehyde dehydrogenase (NAD) activity
.extracellular exosome
.cytosol
.mitochondrial matrix
  + 3 more...
5 EBI-375576,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
6 EBI-375576,EBI-10224192 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
.mitochondrion
.cytoplasm
.nucleoplasm
7 EBI-375576,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
8 EBI-375576,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
9 EBI-375576,EBI-10236940 INPP5J  
  .phosphatidylinositol dephosphorylation
.small molecule metabolic process
.inositol phosphate metabolic process
  + 5 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.dendritic shaft
.growth cone
.plasma membrane
  + 3 more...
10 EBI-375576,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
11 EBI-375576,EBI-10193358 C17orf59  
  .N/A .N/A .N/A
12 EBI-375576,EBI-741214 C19orf25  
  .N/A .N/A .N/A
13 EBI-375576,EBI-525456 BAIAP2  
  .positive regulation of actin cytoskeleton reorganization
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.proline-rich region binding
.identical protein binding
.cytoskeletal adaptor activity
.protein C-terminus binding
.extracellular exosome
.neuron projection
.filopodium
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
ascites25
bladder133
blood8
bone83
bone marrow61
brain65
connective tissue174
embryonic tissue9
eye86
heart11
intestine103
kidney90
liver136
lung56
mammary gland59
mouth287
muscle47
ovary29
pancreas23
pharynx24
placenta84
prostate15
skin66
spleen56
stomach52
testis39
thymus50
thyroid128
trachea405
uterus202
vascular212
Health State
TissuesTPM*
normal63
bladder carcinoma227
breast (mammary gland) tumor32
chondrosarcoma84
colorectal tumor97
gastrointestinal tumor50
germ cell tumor75
glioma46
head and neck tumor186
kidney tumor29
liver tumor249
lung tumor19
non-neoplasia113
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult69
neonate128
fetus66
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue52.4
adrenal gland15.6
appendix17.6
cerebral cortex13.2
colon53.8
duodenum35.9
esophagus21.1
gallbladder63
heart muscle22
kidney45.7
liver21.6
lung25.3
lymph node10.1
ovary49.6
pancreas7.8
placenta44.7
prostate16.8
salivary gland9
skin8.9
small intestine41
spleen13.2
stomach31.6
testis18.6
thyroid gland25
urinary bladder57.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverHigh
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600206, gene) Epidermal growth factor receptor pathway substrate 8; EPS8OMIM


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