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> Protein (NX_Q12933)
Protein (NX_Q12933)
Protein
Gene SymbolTRAF2 to neXtProt (NX_Q12933)
DescriptionTNF receptor-associated factor 2
Chromosome9
Location9q34.3 (139776364 ~ 139821059) to Ensembl
Sequene Features : Isoforms 4, Variants 54, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 54 17
2014-09-19protein level
4 44 17
2014-05-27protein level
4 44 17
2014-02-25protein level
4 44 17
2013-12-09protein level
4 30 17
2013-11-01protein level
4 26 13
2013-09-12protein level
4 26 13
2013-08-17protein level
4 26 13
2013-07-15protein level
4 16 11
2013-06-11protein level
4 16 11
2013-02-12protein level
4 10 40
2012-12-20protein level
4 12 40
2012-10-30protein level
4 17 40
2012-10-07protein level
4 17 10
2012-08-24protein level
4 17 10
2012-07-28protein level
4 17 10
2012-06-08protein level
4 26 10
2012-05-07protein level
4 22 10
2012-04-10protein level
4 22 10
2012-01-13protein level
4 12 10
2011-12-20protein level
4 12 10
2011-11-11protein level
4 12 9
2011-08-23protein level
4 12 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12933-1
0 24 0 55822.5358
NX_Q12933-2
2 23 0 61343.279
NX_Q12933-3
1 23 0 54635.0033
NX_Q12933-4
0 22 0 53020.1195
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355744,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
2 EBI-355744,EBI-368321 PPL  
  .keratinization .structural constituent of cytoskeleton .extracellular exosome
.desmosome
.plasma membrane
  + 3 more...
3 EBI-355744,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
4 EBI-355744,EBI-371750 ERN1  
  .peptidyl-serine trans-autophosphorylation
.insulin metabolic process
.positive regulation of endoplasmic reticulum unfolded protein response
  + 23 more...
.Hsp90 protein binding
.ADP binding
.protein homodimerization activity
  + 7 more...
.IRE1-RACK1-PP2A complex
.IRE1-TRAF2-ASK1 complex
.Ire1 complex
  + 6 more...
5 EBI-355744,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
6 EBI-355744,EBI-2880203 NEBL  
  .cardiac muscle thin filament assembly .actin filament binding
.filamin binding
.structural constituent of muscle
  + 2 more...
.extracellular exosome
.I band
.Z disc
.stress fiber
7 EBI-355744,EBI-958922 BCL10  
  .positive regulation of extrinsic apoptotic signaling pathway
.cellular response to mechanical stimulus
.T cell apoptotic process
  + 29 more...
.NF-kappaB binding
.protein self-association
.protein kinase B binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 8 more...
8 EBI-355744,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
9 EBI-355744,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
10 EBI-355744,EBI-353467 GSTP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.glutathione derivative biosynthetic process
.negative regulation of monocyte chemotactic protein-1 production
  + 27 more...
.nitric oxide binding
.dinitrosyl-iron complex binding
.S-nitrosoglutathione binding
  + 3 more...
.TRAF2-GSTP1 complex
.extracellular exosome
.vesicle
  + 7 more...
11 EBI-355744,EBI-299451 TNFRSF1A  
  .death-inducing signaling complex assembly
.cellular response to estradiol stimulus
.cellular response to mechanical stimulus
  + 29 more...
.tumor necrosis factor-activated receptor activity .synapse
.membrane raft
.receptor complex
  + 10 more...
12 EBI-355744,EBI-358983 TNFRSF1B  
  .extrinsic apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to lipopolysaccharide
  + 8 more...
.ubiquitin protein ligase binding
.tumor necrosis factor-activated receptor activity
.perinuclear region of cytoplasm
.membrane raft
.varicosity
  + 5 more...
13 EBI-355744,EBI-527670 TNFAIP3  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of CD40 signaling pathway
.positive regulation of hepatocyte proliferation
  + 46 more...
.protein self-association
.ubiquitin binding
.ligase activity
  + 5 more...
.extracellular exosome
.cytosol
.centrosome
  + 3 more...
14 EBI-355744,EBI-1054489 USF1  
  .lipid homeostasis
.negative regulation of fibrinolysis
.carbon catabolite regulation of transcription
  + 11 more...
.protein heterodimerization activity
.sequence-specific DNA binding
.bHLH transcription factor binding
  + 6 more...
.transcription factor complex
.nucleoplasm
.nucleus
15 EBI-355744,EBI-739899 ZBTB25  
  .gene expression
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
16 EBI-355744,EBI-525714 CD40  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of protein kinase C signaling
.cellular response to mechanical stimulus
  + 21 more...
.ubiquitin protein ligase binding
.enzyme binding
.receptor activity
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.CD40 receptor complex
  + 6 more...
17 EBI-355744,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
18 EBI-355744,EBI-519280 CDKN1B  
  .mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
19 EBI-355744,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
20 EBI-355744,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
21 EBI-355744,EBI-8472267 KLF3  
  .cellular response to peptide
.multicellular organismal development
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
22 EBI-355744,EBI-739737 EWSR1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleolus
  + 2 more...
23 EBI-355744,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
24 EBI-355744,EBI-711925 ZBTB16  
  .positive regulation of cartilage development
.cartilage development
.positive regulation of NK T cell differentiation
  + 22 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.transcriptional repressor complex
.nuclear speck
.PML body
  + 5 more...
25 EBI-355744,EBI-618165 GABPB1  
  .positive regulation of transcription from RNA polymerase II promoter
.mitochondrion organization
.organelle organization
  + 2 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
26 EBI-355744,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
27 EBI-355744,EBI-10226430 RIPPLY1  
  .bone morphogenesis
.negative regulation of transcription, DNA-templated
.somite rostral/caudal axis specification
  + 4 more...
.N/A .nucleus
28 EBI-355744,EBI-536772 EFEMP1  
  .negative regulation of chondrocyte differentiation
.extracellular matrix organization
.peptidyl-tyrosine phosphorylation
  + 3 more...
.calcium ion binding
.epidermal growth factor receptor binding
.epidermal growth factor-activated receptor activity
.extracellular exosome
.extracellular space
.proteinaceous extracellular matrix
.extracellular region
29 EBI-355744,EBI-2349743 TROAP  
  .cell adhesion .N/A .cytoplasm
30 EBI-355744,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
31 EBI-355744,EBI-49776 MAP3K1  
  .cellular response to mechanical stimulus
.eyelid development in camera-type eye
.stress-activated MAPK cascade
  + 21 more...
.protein kinase binding
.JUN kinase kinase activity
.zinc ion binding
  + 3 more...
.cytosol
.cytoplasm
32 EBI-355744,EBI-517709 BIRC3  
  .negative regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 27 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane raft
.protein complex
.cytosol
  + 3 more...
33 EBI-355744,EBI-514538 BIRC2  
  .regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
34 EBI-355744,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
35 EBI-355744,EBI-358507 RIPK1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 48 more...
.death domain binding
.identical protein binding
.protein complex binding
  + 5 more...
.ripoptosome
.membrane raft
.receptor complex
  + 4 more...
36 EBI-355744,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
37 EBI-355744,EBI-359215 TRADD  
  .regulation of extrinsic apoptotic signaling pathway via death domain receptors
.programmed necrotic cell death
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
  + 17 more...
.death domain binding
.binding, bridging
.identical protein binding
  + 2 more...
.membrane raft
.receptor complex
.death-inducing signaling complex
  + 4 more...
38 EBI-355744,EBI-3951858 NFIL3  
  .cellular response to interleukin-4
.positive regulation of gene expression
.circadian rhythm
  + 3 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
  + 3 more...
.nucleus
39 EBI-355744,EBI-2547810 NRF1  
  .response to electrical stimulus
.response to folic acid
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.cytoplasm
.nucleoplasm
40 EBI-355744,EBI-10239244 GSG1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum membrane
41 EBI-355744,EBI-10242151 FNDC3B  
  .N/A .poly(A) RNA binding .integral component of membrane
42 EBI-355744,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
43 EBI-355744,EBI-10243723 VWA2  
  .protein homooligomerization
.regulation of insulin receptor signaling pathway
.calcium-independent cell-matrix adhesion
.identical protein binding .extracellular exosome
.extracellular space
.basement membrane
44 EBI-355744,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
45 EBI-355744,EBI-9675710 HENMT1  
  .piRNA metabolic process
.gene silencing by RNA
.gene expression
.RNA methylation
.metal ion binding
.RNA methyltransferase activity
.O-methyltransferase activity
.RNA binding
.P granule
46 EBI-355744,EBI-744761 CYB5R2  
  .oxidation-reduction process
.sterol biosynthetic process
.cytochrome-b5 reductase activity, acting on NAD(P)H .membrane
.mitochondrion
.nucleus
47 EBI-355744,EBI-724630 ZFAND6  
  .cellular response to tumor necrosis factor
.regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of apoptotic process
  + 2 more...
.polyubiquitin binding
.zinc ion binding
.DNA binding
.cytoplasm
48 EBI-355744,EBI-2841978 ZNF544  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
49 EBI-355744,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
50 EBI-355744,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
51 EBI-355744,EBI-10255155 ZNF662  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.metal ion binding
.transcription cofactor activity
.DNA binding
.nucleus
52 EBI-355744,EBI-2827999 PCGF5  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.zinc ion binding .PcG protein complex
.centrosome
.nucleolus
.nucleus
53 EBI-355744,EBI-720304 ZNF410  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
54 EBI-355744,EBI-8465536 C17orf82  
  .N/A .N/A .N/A
55 EBI-355744,EBI-10260504 CDC20B  
  .N/A .N/A .N/A
56 EBI-355744,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
57 EBI-355744,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
58 EBI-355744,EBI-749333 C5orf55  
  .N/A .N/A .extracellular region
59 EBI-355744,EBI-8656665 NATD1  
  .N/A .N/A .N/A
60 EBI-355744,EBI-625509 ZNF655  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
61 EBI-355744,EBI-10268317 ASCC1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA dealkylation involved in DNA repair
.DNA repair
.RNA binding .cytoplasm
.transcription factor complex
.nucleoplasm
62 EBI-355744,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
63 EBI-355744,EBI-10220600 IQUB  
  .cilium morphogenesis
.smoothened signaling pathway
.N/A .motile cilium
.acrosomal vesicle
64 EBI-355744,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
65 EBI-355744,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
66 EBI-355744,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
67 EBI-355744,EBI-2949647 EDARADD  
  .trachea gland development
.odontogenesis of dentin-containing tooth
.cell differentiation
  + 2 more...
.N/A .cytoplasm
68 EBI-355744,EBI-356349 TANK  
  .innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
69 EBI-355744,EBI-746309 GPKOW  
  .N/A .nucleic acid binding .nucleoplasm
70 EBI-355760,EBI-1056653 TNFRSF14  
  .positive regulation of T cell migration
.defense response to Gram-positive bacterium
.defense response to Gram-negative bacterium
  + 7 more...
.ubiquitin protein ligase binding
.tumor necrosis factor-activated receptor activity
.virus receptor activity
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
71 EBI-355744,EBI-740711 TIFA  
  .I-kappaB kinase/NF-kappaB signaling .N/A .N/A
72 EBI-355744,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
73 EBI-355744,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
74 EBI-355744,EBI-10290053 PGBD1  
  .N/A .scavenger receptor activity
.sequence-specific DNA binding transcription factor activity
.membrane
.nucleus
75 EBI-355744,EBI-948288 ZNF488  
  .positive regulation of oligodendrocyte differentiation
.negative regulation of transcription, DNA-templated
.oligodendrocyte development
  + 2 more...
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
76 EBI-355744,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
77 EBI-355744,EBI-358011 MAP3K14  
  .cellular response to mechanical stimulus
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 9 more...
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
  + 3 more...
.cytosol
.cytoplasm
78 EBI-355744,EBI-739534 CDCA3  
  .cell division
.protein ubiquitination
.mitotic nuclear division
.N/A .cytosol
79 EBI-355744,EBI-2949792 NUDT16L1  
  .N/A .poly(A) RNA binding
.snoRNA binding
.hydrolase activity
.cytoplasm
80 EBI-355744,EBI-10297077 FDXACB1  
  .rRNA base methylation
.tRNA processing
.rRNA (uridine-N3-)-methyltransferase activity
.ATP binding
.magnesium ion binding
.tRNA binding
.cytoplasm
81 EBI-355744,EBI-745392 SYT17  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.plasma membrane
.trans-Golgi network
82 EBI-355744,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
83 EBI-355744,EBI-9675976 SNRNP25  
  .RNA splicing
.mRNA processing
.N/A .intercellular bridge
.cytoplasm
.U12-type spliceosomal complex
  + 2 more...
84 EBI-355744,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
85 EBI-355744,EBI-8644516 TEKT3  
  .regulation of fertilization
.cilium morphogenesis
.sperm motility
.N/A .extracellular exosome
.sperm flagellum
.microtubule
  + 2 more...
86 EBI-355744,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
87 EBI-355744,EBI-10303844 NMUR2  
  .chloride transmembrane transport
.arachidonic acid secretion
.response to pain
  + 14 more...
.neuromedin U binding
.GTP binding
.intracellular calcium activated chloride channel activity
  + 2 more...
.integral component of membrane
.plasma membrane
88 EBI-355744,EBI-2371956 FAM192A  
  .N/A .N/A .nucleus
89 EBI-355744,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
90 EBI-355744,EBI-2872322 SMG9  
  .gene expression
.nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.identical protein binding .cytosol
.intracellular
91 EBI-355744,EBI-1384100 TAOK3  
  .protein autophosphorylation
.positive regulation of JNK cascade
.negative regulation of JNK cascade
  + 11 more...
.transferase activity
.ATP binding
.protein kinase inhibitor activity
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
92 EBI-355744,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
93 EBI-355744,EBI-744488 PRKRIP1  
  .negative regulation of phosphorylation
.negative regulation of protein kinase activity
.renal system process
.protein kinase binding
.protein kinase inhibitor activity
.double-stranded RNA binding
.extracellular exosome
.nucleolus
94 EBI-355744,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
95 EBI-355744,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
96 EBI-355744,EBI-2851995 TNFRSF12A  
  .positive regulation of extrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
.regulation of wound healing
  + 5 more...
.N/A .integral component of membrane
.cell surface
.plasma membrane
.ruffle
97 EBI-355744,EBI-740884 AASDHPPT  
  .small molecule metabolic process
.pantothenate metabolic process
.water-soluble vitamin metabolic process
.vitamin metabolic process
.holo-[acyl-carrier-protein] synthase activity
.magnesium ion binding
.extracellular exosome
.cytosol
98 EBI-355744,EBI-722397 RNF146  
  .positive regulation of canonical Wnt signaling pathway
.protein K48-linked ubiquitination
.protein autoubiquitination
  + 2 more...
.poly-ADP-D-ribose binding
.ubiquitin protein ligase activity
.ligase activity
  + 2 more...
.cytosol
.nucleus
99 EBI-355744,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
100 EBI-355744,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
101 EBI-355744,EBI-395282 AFF4  
  .spermatid development
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity .transcriptionally active chromatin
.transcription elongation factor complex
.mitochondrion
  + 3 more...
102 EBI-355744,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
103 EBI-355744,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
104 EBI-355744,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
105 EBI-355744,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
106 EBI-355744,EBI-717229 TSSC4  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites125
bladder66
blood65
bone13
bone marrow102
brain79
cervix185
connective tissue120
embryonic tissue28
esophagus49
eye52
heart22
intestine77
kidney99
liver43
lung56
lymph112
mammary gland92
mouth105
muscle9
ovary88
pancreas28
parathyroid48
pituitary gland60
placenta42
prostate42
skin80
spleen449
stomach31
testis119
thymus426
thyroid21
trachea96
umbilical cord145
uterus30
vascular58
Health State
TissuesTPM*
normal60
breast (mammary gland) tumor139
cervical tumor57
chondrosarcoma48
colorectal tumor44
esophageal tumor57
gastrointestinal tumor50
germ cell tumor151
glioma139
head and neck tumor44
kidney tumor43
leukemia52
liver tumor93
lung tumor77
lymphoma138
non-neoplasia103
ovarian tumor65
pancreatic tumor57
primitive neuroectodermal tumor of the CNS220
retinoblastoma64
skin tumor23
soft tissue/muscle tissue tumor39
uterine tumor22
Developmental Stage
TissuesTPM*
adult61
embryoid body57
neonate225
fetus39
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.7
adrenal gland4.7
appendix11.3
bone marrow6.8
cerebral cortex3.7
colon6.6
duodenum7.7
esophagus7
gallbladder5.3
heart muscle4.9
kidney4.6
liver3.4
lung6.6
lymph node15.6
ovary4.7
pancreas2.3
placenta7.3
prostate7.1
salivary gland8
skin7.4
small intestine7.3
spleen11.2
stomach8.5
testis10.2
thyroid gland7.9
urinary bladder7.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowLow
breastLow
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumLow
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyLow
lateral ventricleLow
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumLow
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Low
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601895, gene) Tnf receptor-associated factor 2; TRAF2OMIM


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