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> Protein (NX_Q12955)
Protein (NX_Q12955)
Protein
Gene SymbolANK3 to neXtProt (NX_Q12955)
DescriptionAnkyrin-3
Chromosome10
Location10q21.2 (61786056 ~ 62493248) to Ensembl
Sequene Features : Isoforms 5, Variants 706, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of sodium ion transmembrane transporter activity
.negative regulation of delayed rectifier potassium channel activity
.positive regulation of membrane depolarization during cardiac muscle cell action potential
  + 23 more...
.cadherin binding
.ion channel binding
.protein binding, bridging
  + 3 more...
.postsynaptic membrane
.axon initial segment
.costamere
  + 17 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 706 13
2014-09-19protein level
5 467 13
2014-05-27protein level
5 465 14
2014-02-25protein level
4 459 17
2013-12-09protein level
4 372 17
2013-11-01protein level
4 333 17
2013-09-12protein level
4 333 17
2013-08-17protein level
4 333 17
2013-07-15protein level
3 218 17
2013-06-11protein level
3 218 17
2013-02-12protein level
3 115 26
2012-12-20protein level
3 114 26
2012-10-30protein level
3 138 26
2012-10-07protein level
1 133 10
2012-08-24protein level
1 84 10
2012-07-28protein level
1 84 10
2012-06-08protein level
1 92 10
2012-05-07protein level
1 92 10
2012-04-10protein level
1 92 10
2012-01-13protein level
1 56 10
2011-12-20protein level
1 56 10
2011-11-11protein level
1 56 10
2011-08-23protein level
1 56 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12955-3
124 80 9 480112.0938
NX_Q12955-4
2 77 9 204014.6629
NX_Q12955-5
1 78 9 202465.516
NX_Q12955-6
1 44 2 111028.5678
NX_Q12955-7
3 64 7 160845.8127
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2691178,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood16
bone marrow20
brain116
connective tissue40
ear62
embryonic tissue28
esophagus49
eye90
heart100
intestine30
kidney90
larynx42
liver9
lung47
mammary gland92
mouth45
muscle75
nerve128
pancreas4
parathyroid582
pharynx73
pituitary gland60
placenta286
prostate94
skin42
testis25
thymus12
thyroid42
trachea115
uterus30
Health State
TissuesTPM*
normal85
breast (mammary gland) tumor96
chondrosarcoma12
colorectal tumor53
esophageal tumor57
germ cell tumor83
glioma46
head and neck tumor52
kidney tumor87
leukemia21
liver tumor10
lung tumor9
non-neoplasia51
pancreatic tumor9
prostate cancer96
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor47
uterine tumor33
Developmental Stage
TissuesTPM*
adult91
embryoid body28
blastocyst32
fetus96
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.7
adrenal gland6.3
appendix5.9
cerebral cortex31.6
colon22.8
duodenum34
esophagus15.4
gallbladder20.8
heart muscle58.8
kidney73.9
liver10.2
lung20.7
lymph node5
ovary9.5
pancreas4.8
placenta34.2
prostate19.3
salivary gland28.4
skin28.7
small intestine23.2
spleen8.4
stomach10.6
testis7.7
thyroid gland33.6
urinary bladder14.3
Tissues
TissuesExpression level
appendixMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumLow
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungLow
nasopharynxMedium
oral mucosaLow
pancreasMedium
parathyroid glandMedium
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleHigh
skin 1Medium
skin 2Medium
small intestineMedium
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600465, gene) Ankyrin 3; ANK3OMIM


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