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> Protein (NX_Q12972)
Protein (NX_Q12972)
Protein
Gene SymbolPPP1R8 to neXtProt (NX_Q12972)
DescriptionNuclear inhibitor of protein phosphatase 1
Chromosome1
Location1p35.3 (28157289 ~ 28178187) to Ensembl
Sequene Features : Isoforms 3, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA phosphodiester bond hydrolysis
.negative regulation of catalytic activity
.RNA splicing
  + 5 more...
.ribonuclease E activity
.protein phosphatase type 1 regulator activity
.protein serine/threonine phosphatase inhibitor activity
  + 3 more...
.nuclear speck
.cytoplasm
.spliceosomal complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 30 5
2014-09-19protein level
3 22 5
2014-05-27protein level
3 22 5
2014-02-25protein level
3 21 5
2013-12-09protein level
3 15 5
2013-11-01protein level
3 12 5
2013-09-12protein level
3 12 5
2013-08-17protein level
3 12 5
2013-07-15protein level
3 11 5
2013-06-11protein level
3 11 5
2013-02-12protein level
3 4 12
2012-12-20protein level
3 4 12
2012-10-30protein level
3 5 12
2012-10-07protein level
3 5 5
2012-08-24protein level
3 5 5
2012-07-28protein level
3 5 5
2012-06-08protein level
3 17 5
2012-05-07protein level
3 15 5
2012-04-10protein level
3 15 5
2012-01-13protein level
3 16 5
2011-12-20protein level
3 16 5
2011-11-11protein level
3 16 4
2011-08-23protein level
3 16 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12972-1
6 8 0 38454.7199
NX_Q12972-2
0 8 0 22696.5482
NX_Q12972-3
1 3 0 13335.9129
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-716633,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
2 EBI-716633,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites251
bladder66
blood130
bone55
bone marrow20
brain74
cervix123
connective tissue60
embryonic tissue61
eye23
heart89
intestine51
kidney61
liver48
lung23
lymph203
lymph node22
mammary gland72
mouth15
muscle75
ovary29
pancreas23
parathyroid97
pharynx24
pituitary gland181
placenta52
prostate110
skin33
spleen56
stomach31
testis82
thymus163
trachea19
uterus60
vascular154
Health State
TissuesTPM*
normal62
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma72
colorectal tumor44
gastrointestinal tumor92
germ cell tumor170
glioma27
kidney tumor58
leukemia74
liver tumor72
lung tumor9
lymphoma207
non-neoplasia82
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS110
prostate cancer86
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor71
uterine tumor33
Developmental Stage
TissuesTPM*
adult64
embryoid body85
blastocyst65
neonate96
fetus52
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.5
adrenal gland16.8
appendix23.5
bone marrow24.2
cerebral cortex20.3
colon22.7
duodenum17
esophagus24.1
gallbladder22.2
heart muscle19
kidney18
liver11.8
lung20.2
lymph node33.2
ovary31.3
pancreas10
placenta24.2
prostate19.8
salivary gland13.7
skin17.2
small intestine18.7
spleen24.3
stomach18.6
testis26.8
thyroid gland26.8
urinary bladder28.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602636, gene) Protein phosphatase 1, regulatory subunit 8; PPP1R8OMIM


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