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> Protein (NX_Q12982)
Protein (NX_Q12982)
Protein
Gene SymbolBNIP2 to neXtProt (NX_Q12982)
DescriptionBCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Chromosome15
Location15q22.2 (59951345 ~ 59981733) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of muscle cell differentiation
.positive regulation of GTPase activity
.negative regulation of apoptotic process
  + 2 more...
.identical protein binding
.calcium ion binding
.GTPase activator activity
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 4
2014-09-19protein level
2 29 4
2014-05-27protein level
2 29 4
2014-02-25protein level
2 29 4
2013-12-09protein level
2 19 4
2013-11-01protein level
2 18 3
2013-09-12protein level
2 18 3
2013-08-17protein level
2 18 3
2013-07-15protein level
2 10 1
2013-06-11protein level
2 10 1
2013-02-12protein level
2 8 4
2012-12-20protein level
2 8 4
2012-10-30protein level
2 11 4
2012-10-07protein level
2 11 2
2012-08-24protein level
2 10 2
2012-07-28protein level
2 10 2
2012-06-08protein level
2 11 2
2012-05-07protein level
2 10 2
2012-04-10protein level
2 10 2
2012-01-13protein level
2 5 2
2011-12-20protein level
2 5 2
2011-11-11protein level
2 5 2
2011-08-23protein level
2 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12982-1
0 10 1 35995.0156
NX_Q12982-2
3 10 1 43107.5745
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-752094,EBI-1383583 FRK  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
  + 2 more...
2 EBI-752094,EBI-721019 KLC1  
  .stress granule disassembly
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.viral process
  + 4 more...
.microtubule motor activity
.motor activity
.growth cone
.cytoplasmic membrane-bounded vesicle
.membrane
  + 3 more...
3 EBI-752094,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
4 EBI-752094,EBI-311356 MYO5B  
  .transmembrane transport
.endosome localization
.vesicle-mediated transport
  + 4 more...
.Rab GTPase binding
.ATP binding
.microfilament motor activity
.extracellular exosome
.apical cortex
.protein complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites75
bladder267
blood122
bone13
bone marrow61
brain2
cervix103
connective tissue13
embryonic tissue65
esophagus198
eye47
heart89
intestine8
kidney4
liver82
lung17
lymph22
lymph node22
mammary gland6
mouth256
muscle18
nerve193
ovary9
pancreas9
pituitary gland60
placenta24
prostate15
skin75
spleen168
stomach10
testis2
thymus12
thyroid21
tonsil58
trachea270
uterus21
vascular58
Health State
TissuesTPM*
normal72
bladder carcinoma341
breast (mammary gland) tumor10
cervical tumor115
chondrosarcoma24
colorectal tumor17
esophageal tumor231
gastrointestinal tumor59
germ cell tumor117
glioma9
head and neck tumor67
kidney tumor43
leukemia74
liver tumor114
lung tumor48
lymphoma13
non-neoplasia134
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS39
prostate cancer19
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor79
uterine tumor44
Developmental Stage
TissuesTPM*
adult11
embryoid body57
blastocyst65
neonate225
fetus3
infant42
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue53.7
adrenal gland38
appendix59.6
bone marrow149.4
cerebral cortex18.3
colon41.8
duodenum45.7
esophagus44.5
gallbladder48.1
heart muscle50.1
kidney31.1
liver34.3
lung52.5
lymph node64.9
ovary36.6
pancreas15.4
placenta48.2
prostate46.1
salivary gland23.5
skin23.9
small intestine52.2
spleen50.6
stomach41.7
testis33.9
thyroid gland42.3
urinary bladder63.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowHigh
breastMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonLow
endometrium 2Medium
esophagusMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
liverLow
lungHigh
lymph nodeHigh
nasopharynxLow
oral mucosaMedium
ovaryLow
parathyroid glandLow
placentaHigh
salivary glandLow
skeletal muscleLow
skin 1Medium
skin 2Medium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603292, gene) Bcl2/adenovirus e1b 19-kd protein-interacting protein 2; BNIP2OMIM


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