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> Protein (NX_Q12983)
Protein (NX_Q12983)
Protein
Gene SymbolBNIP3 to neXtProt (NX_Q12983)
DescriptionBCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Chromosome10
Location10q26.3 (133781578 ~ 133795435) to Ensembl
Sequene Features : Isoforms 1, Variants 21, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intrinsic apoptotic signaling pathway in response to hypoxia
.toxin transport
.mitochondrial outer membrane permeabilization
  + 28 more...
.GTPase binding
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.mitochondrial membrane
.integral component of mitochondrial outer membrane
.dendrite
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 21 4
2014-09-19protein level
1 13 4
2014-05-27protein level
1 13 5
2014-02-25protein level
1 13 5
2013-12-09protein level
1 13 5
2013-11-01protein level
1 13 5
2013-09-12protein level
1 13 5
2013-08-17protein level
1 13 5
2013-07-15protein level
1 9 4
2013-06-11protein level
1 9 4
2013-02-12protein level
1 5 5
2012-12-20protein level
1 5 5
2012-10-30protein level
1 5 5
2012-10-07protein level
1 5 5
2012-08-24protein level
1 3 5
2012-07-28protein level
1 3 5
2012-06-08protein level
1 4 5
2012-05-07protein level
1 4 5
2012-04-10protein level
1 4 5
2012-01-13protein level
1 2 5
2011-12-20protein level
1 2 5
2011-11-11protein level
1 2 4
2011-08-23protein level
1 2 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q12983-1
9 0 1 21527.5942
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749464,EBI-849893 BNIP3L  
  .mitochondrial outer membrane permeabilization
.defense response to virus
.negative regulation of apoptotic process
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.lamin binding
.intrinsic component of membrane
.integral component of membrane
.endoplasmic reticulum
  + 3 more...
2 EBI-749464,EBI-1054131 OPA1  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.cellular senescence
.negative regulation of release of cytochrome c from mitochondria
  + 10 more...
.GTP binding
.GTPase activity
.magnesium ion binding
.dendrite
.mitochondrial crista
.integral component of membrane
  + 7 more...
3 EBI-749464,EBI-723946 TMEM11  
  .mitochondrion organization .N/A .integral component of mitochondrial inner membrane
.integral component of plasma membrane
4 EBI-749464,EBI-10173166 LDLRAD1  
  .N/A .N/A .integral component of membrane
5 EBI-749464,EBI-359761 KTN1  
  .small GTPase mediated signal transduction
.microtubule-based movement
.poly(A) RNA binding .integral component of membrane
.membrane
.integral component of plasma membrane
  + 2 more...
6 EBI-749464,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
7 EBI-749464,EBI-3939278 CLEC7A  
  .innate immune response
.defense response to protozoan
.T cell activation
  + 6 more...
.metal ion binding
.MHC protein binding
.carbohydrate binding
.signaling pattern recognition receptor activity
.integral component of membrane
.plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
blood24
bone111
brain27
connective tissue53
embryonic tissue32
eye28
heart44
intestine8
kidney71
liver14
lung50
lymph node89
mammary gland19
muscle28
ovary19
pancreas46
parathyroid48
placenta17
prostate47
salivary gland49
skin28
stomach10
testis32
umbilical cord72
uterus64
vascular19
Health State
TissuesTPM*
normal39
adrenal tumor158
breast (mammary gland) tumor10
chondrosarcoma120
colorectal tumor17
gastrointestinal tumor8
germ cell tumor37
glioma83
kidney tumor14
leukemia21
liver tumor10
lung tumor48
lymphoma13
non-neoplasia20
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS55
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult32
embryoid body42
neonate32
fetus30
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.9
adrenal gland19.2
appendix6.2
bone marrow2.2
cerebral cortex32.4
colon4.9
duodenum4.9
esophagus14.7
gallbladder15
heart muscle39
kidney43.5
liver45.9
lung11.8
lymph node7
ovary27.1
pancreas88.1
placenta21.7
prostate32.2
salivary gland25.1
skin14.2
small intestine6.3
spleen7.3
stomach8.4
testis10.3
thyroid gland15.4
urinary bladder6.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603293, gene) Bcl2/adenovirus e1b 19-kd protein-interacting protein 3; BNIP3OMIM


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