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> Protein (NX_Q13043)
Protein (NX_Q13043)
Protein
Gene SymbolSTK4 to neXtProt (NX_Q13043)
DescriptionSerine/threonine-protein kinase 4
Chromosome20
Location20q13.12 (43595115 ~ 43708600) to Ensembl
Sequene Features : Isoforms 2, Variants 63, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 63 12
2014-09-19protein level
2 52 12
2014-05-27protein level
2 52 13
2014-02-25protein level
2 52 13
2013-12-09protein level
2 46 13
2013-11-01protein level
2 46 13
2013-09-12protein level
2 46 13
2013-08-17protein level
2 46 13
2013-07-15protein level
2 28 12
2013-06-11protein level
2 28 12
2013-02-12protein level
2 17 47
2012-12-20protein level
2 17 47
2012-10-30protein level
2 15 47
2012-10-07protein level
2 15 24
2012-08-24protein level
2 13 24
2012-07-28protein level
2 13 24
2012-06-08protein level
2 21 24
2012-05-07protein level
2 17 24
2012-04-10protein level
2 17 24
2012-01-13protein level
2 17 24
2011-12-20protein level
2 17 24
2011-11-11protein level
2 17 24
2011-08-23protein level
2 17 23
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13043-1
4 14 7 55594.7116
NX_Q13043-2
3 14 7 52301.7541
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-367376,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-367376,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
3 EBI-367376,EBI-960081 RASSF2  
  .negative regulation of NIK/NF-kappaB signaling
.homeostasis of number of cells
.bone remodeling
  + 6 more...
.N/A .cytoplasm
.nucleus
4 EBI-367376,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
5 EBI-367376,EBI-353193 PRDX1  
  .hydrogen peroxide catabolic process
.regulation of NF-kappaB import into nucleus
.natural killer cell mediated cytotoxicity
  + 9 more...
.poly(A) RNA binding
.heme binding
.thioredoxin peroxidase activity
.peroxidase activity
.extracellular exosome
.melanosome
.cytosol
  + 7 more...
6 EBI-367376,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
7 EBI-367376,EBI-1043216 SLMAP  
  .muscle contraction .N/A .sarcolemma
.integral component of plasma membrane
.microtubule organizing center
.smooth endoplasmic reticulum
8 EBI-367376,EBI-2933412 RASSF6  
  .positive regulation of apoptotic process
.signal transduction
.apoptotic process
.N/A .N/A
9 EBI-367376,EBI-2558745 MOB1B  
  .protein autophosphorylation
.positive regulation of phosphorylation
.hippo signaling
.metal ion binding
.kinase binding
.kinase activator activity
.extracellular exosome
.cytosol
.cytoplasm
.nucleus
10 EBI-367376,EBI-2845202 RASSF3  
  .signal transduction .identical protein binding .plasma membrane
.microtubule
.cytoplasm
11 EBI-367376,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
12 EBI-367376,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
13 EBI-367376,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
14 EBI-367376,EBI-2933362 RASSF4  
  .signal transduction
.cell cycle
.N/A .N/A
15 EBI-367376,EBI-1017775 SAV1  
  .regulation of stem cell maintenance
.intestinal epithelial cell differentiation
.lung epithelial cell differentiation
  + 7 more...
.N/A .cytosol
.cytoplasm
.nucleus
16 EBI-367376,EBI-748229 MOB1A  
  .hippo signaling .metal ion binding .extracellular exosome
.cytosol
17 EBI-367376,EBI-438698 RASSF1  
  .negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
blood155
bone27
bone marrow82
brain20
cervix61
connective tissue20
ear124
embryonic tissue28
esophagus99
eye23
intestine47
kidney18
liver19
lung35
lymph45
lymph node256
mammary gland39
mouth15
muscle75
ovary49
pancreas32
pharynx171
placenta7
prostate36
salivary gland49
skin52
stomach31
testis20
thymus100
thyroid42
trachea19
uterus25
vascular77
Health State
TissuesTPM*
normal36
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma36
colorectal tumor35
esophageal tumor115
gastrointestinal tumor33
germ cell tumor37
glioma27
head and neck tumor22
kidney tumor14
leukemia222
liver tumor20
lung tumor19
lymphoma41
non-neoplasia41
ovarian tumor65
pancreatic tumor28
prostate cancer57
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor47
uterine tumor11
Developmental Stage
TissuesTPM*
adult49
embryoid body28
blastocyst65
fetus37
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.3
adrenal gland9.8
appendix38.2
bone marrow37.8
cerebral cortex8.6
colon12
duodenum9.4
esophagus9.7
gallbladder15
heart muscle3.8
kidney6.2
liver6
lung15.7
lymph node47.6
ovary7.8
pancreas3.4
placenta10.6
prostate7.1
salivary gland6.7
skin10.4
small intestine12.3
spleen29.9
stomach13.8
testis12.5
thyroid gland9.4
urinary bladder19.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604965, gene) Serine/threonine protein kinase 4; STK4OMIM
2(#614868, phenotype) T-cell immunodeficiency, recurrent infections, and autoimmunity withOMIM


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2014-2019 (C) Yonsei Proteome Research Center