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> Protein (NX_Q13049)
Protein (NX_Q13049)
Protein
Gene SymbolTRIM32 to neXtProt (NX_Q13049)
DescriptionE3 ubiquitin-protein ligase TRIM32
Chromosome9
Location9q33.1 (119449581 ~ 119463579) to Ensembl
Sequene Features : Isoforms 1, Variants 84, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cell motility
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of viral release from host cell
  + 21 more...
.ubiquitin protein ligase activity
.protein self-association
.ubiquitin binding
  + 8 more...
.striated muscle myosin thick filament
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 84 11
2014-09-19protein level
1 70 11
2014-05-27protein level
1 70 11
2014-02-25protein level
1 70 11
2013-12-09protein level
1 58 11
2013-11-01protein level
1 57 10
2013-09-12protein level
1 57 10
2013-08-17protein level
1 57 10
2013-07-15protein level
1 40 4
2013-06-11protein level
1 40 4
2013-02-12protein level
1 18 4
2012-12-20protein level
1 17 4
2012-10-30protein level
1 21 4
2012-10-07protein level
1 21 4
2012-08-24protein level
1 21 4
2012-07-28protein level
1 21 4
2012-06-08protein level
1 23 4
2012-05-07protein level
1 16 4
2012-04-10protein level
1 16 4
2012-01-13protein level
1 11 4
2011-12-20protein level
1 11 4
2011-11-11protein level
1 11 4
2011-08-23protein level
1 10 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13049-1
33 0 0 71942.1929
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742790,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-742790,EBI-742764 PDE9A  
  .cGMP-mediated signaling
.metabolic process
.blood coagulation
.signal transduction
.3',5'-cyclic-GMP phosphodiesterase activity
.metal ion binding
.3',5'-cyclic-nucleotide phosphodiesterase activity
.perinuclear region of cytoplasm
.perikaryon
.ruffle membrane
  + 3 more...
3 EBI-742790,EBI-7797649 SCGB1A1  
  .response to fibroblast growth factor
.response to glucocorticoid
.regulation of inflammatory response
  + 16 more...
.phospholipase A2 inhibitor activity .extracellular exosome
.secretory granule
.rough endoplasmic reticulum
  + 2 more...
4 EBI-742790,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
5 EBI-742790,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
6 EBI-742790,EBI-10246152 SYT6  
  .acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
7 EBI-742790,EBI-2130181 UBE2U  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.histone ubiquitination
.DNA repair
.protein polyubiquitination
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 2 more...
.HULC complex
.cytoplasm
.nuclear chromatin
8 EBI-742790,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
9 EBI-742790,EBI-5655540 CLIP4  
  .N/A .N/A .N/A
10 EBI-742790,EBI-924214 TRIM5  
  .negative regulation of viral release from host cell
.protein K63-linked ubiquitination
.protein trimerization
  + 13 more...
.protein homodimerization activity
.identical protein binding
.ligase activity
  + 3 more...
.cytosol
.cytoplasm
.cytoplasmic mRNA processing body
11 EBI-742790,EBI-711226 UBQLN4  
  .regulation of proteasomal ubiquitin-dependent protein catabolic process .identical protein binding
.polyubiquitin binding
.perinuclear region of cytoplasm
.cytosol
.endoplasmic reticulum membrane
  + 2 more...
12 EBI-742790,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
13 EBI-742790,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
14 EBI-742790,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bone13
brain20
connective tissue20
embryonic tissue9
eye33
heart44
intestine25
kidney9
lung47
mammary gland6
mouth15
muscle28
ovary39
pancreas4
placenta52
prostate26
skin52
stomach31
testis18
thymus12
thyroid21
umbilical cord72
uterus51
Health State
TissuesTPM*
normal24
adrenal tumor79
bladder carcinoma113
chondrosarcoma48
colorectal tumor44
gastrointestinal tumor25
germ cell tumor11
glioma37
head and neck tumor7
lung tumor9
non-neoplasia20
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma64
skin tumor47
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult31
embryoid body14
blastocyst16
neonate32
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.5
adrenal gland7.5
appendix5.4
cerebral cortex6.4
colon5.9
duodenum5.6
esophagus7
gallbladder7.3
heart muscle6.4
kidney4.7
liver2.1
lung5.3
lymph node7.5
ovary9.6
pancreas3.3
placenta5.7
prostate6.7
salivary gland3.7
skin3.5
small intestine6.3
spleen5.7
stomach5
testis5.9
thyroid gland6.3
urinary bladder8.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#254110, phenotype) Muscular dystrophy, limb-girdle, type 2h; LGMD2HOMIM
2(*602290, gene) Tripartite motif-containing protein 32; TRIM32OMIM


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