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> Protein (NX_Q13064)
Protein (NX_Q13064)
Gene SymbolMKRN3 to neXtProt (NX_Q13064)
DescriptionProbable E3 ubiquitin-protein ligase makorin-3
Location15q11.2 (23810454 ~ 23873064) to Ensembl
Sequene Features : Isoforms 1, Variants 166, PTMsto neXtProt Sequence Features
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 166 0
2014-09-19protein level
1 123 0
2014-05-27protein level
1 123 1
2014-02-25protein level
1 123 1
2013-12-09protein level
1 109 1
2013-11-01protein level
1 104 1
2013-09-12protein level
1 103 1
2013-08-17protein level
1 103 1
2013-07-15protein level
1 64 0
2013-06-11protein level
1 64 0
2013-02-12protein level
1 23 0
2012-12-20protein level
1 24 0
2012-10-30protein level
1 28 0
2012-10-07protein level
1 28 0
2012-08-24protein level
1 24 0
2012-07-28protein level
1 24 0
2012-06-08protein level
1 24 0
2012-05-07protein level
1 14 0
2012-04-10protein level
1 14 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
19 0 1 55608.5449
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2340269,EBI-398437 MDM4  
  .cellular response to hypoxia
.negative regulation of cell cycle arrest
.protein stabilization
  + 9 more...
.enzyme binding
.zinc ion binding
2 EBI-2340269,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
3 EBI-2340269,EBI-347351 TFAP2A  
  .negative regulation of reactive oxygen species metabolic process
.metanephric nephron development
.basement membrane organization
  + 43 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 14 more...
.intracellular membrane-bounded organelle
.Golgi apparatus
  + 3 more...
4 EBI-2340269,EBI-750962 ERCC1  
  .chromosome organization
.embryonic organ development
  + 26 more...
.protein domain specific binding
.protein C-terminus binding
.endonuclease activity
  + 2 more...
.transcription factor TFIID complex
  + 3 more...
5 EBI-2340269,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
  + 7 more...
6 EBI-2340269,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
  + 3 more...
7 EBI-2340269,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
  + 2 more...
8 EBI-2340269,EBI-716172 MRPS6  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.small ribosomal subunit rRNA binding
.structural constituent of ribosome
.small ribosomal subunit
.mitochondrial small ribosomal subunit
.mitochondrial inner membrane
9 EBI-2340269,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
10 EBI-2340269,EBI-744603 SF1  
  .negative regulation of nucleic acid-templated transcription
.regulation of steroid biosynthetic process
.negative regulation of smooth muscle cell proliferation
  + 7 more...
.poly(A) RNA binding
.zinc ion binding
.RNA binding
.transcription corepressor activity
.spliceosomal complex
11 EBI-2340269,EBI-2889252 NABP1  
  .response to ionizing radiation
.mitotic cell cycle checkpoint
.cellular response to DNA damage stimulus
  + 2 more...
.RNA binding
.single-stranded DNA binding
.SOSS complex
12 EBI-2340269,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
13 EBI-2340269,EBI-1046387 TTC25  
  .N/A .N/A .cytoplasm
14 EBI-2340269,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.spindle pole
15 EBI-2340269,EBI-739773 CRACR2A  
  .positive regulation of calcium ion transport
.activation of store-operated calcium channel activity
.immune system process
.store-operated calcium entry
.calcium ion binding .membrane
.Golgi apparatus
  + 2 more...
16 EBI-2340269,EBI-740781 TCHP  
  .negative regulation of cell growth
.apoptotic process
.N/A .apical cortex
.keratin filament
.plasma membrane
  + 3 more...
17 EBI-2340269,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
18 EBI-2340269,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
19 EBI-2340269,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
20 EBI-2340269,EBI-741626 FAM124B  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
Health State
esophageal tumor57
germ cell tumor7
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor7
Developmental Stage
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
cerebral cortex3.4
salivary gland1.1
TumorNumber of patients and Staining levels
breast cancer
cervical cancer
colorectal cancer
endometrial cancer
head and neck cancer
liver cancer
lung cancer
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
No.Disease DescriptionRef.
1(*603856, gene) Makorin 3; MKRN3OMIM

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