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> Protein (NX_Q13077)
Protein (NX_Q13077)
Protein
Gene SymbolTRAF1 to neXtProt (NX_Q13077)
DescriptionTNF receptor-associated factor 1
Chromosome9
Location9q33.2 (123664671 ~ 123691451) to Ensembl
Sequene Features : Isoforms 2, Variants 55, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 55 3
2014-09-19protein level
2 43 3
2014-05-27protein level
2 43 3
2014-02-25protein level
2 43 3
2013-12-09protein level
2 33 3
2013-11-01protein level
2 31 3
2013-09-12protein level
2 31 4
2013-08-17protein level
2 31 4
2013-07-15protein level
2 22 4
2013-06-11protein level
2 22 4
2013-02-12protein level
2 14 7
2012-12-20protein level
2 15 7
2012-10-30protein level
2 18 7
2012-10-07protein level
2 18 4
2012-08-24protein level
2 11 4
2012-07-28protein level
2 11 4
2012-06-08protein level
2 14 4
2012-05-07protein level
2 14 4
2012-04-10protein level
2 14 4
2012-01-13protein level
1 11 4
2011-12-20protein level
1 11 4
2011-11-11protein level
1 11 4
2011-08-23protein level
1 11 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13077-1
6 14 0 46133.8093
NX_Q13077-2
0 14 0 33274.8594
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359224,EBI-10172867 SSC5D  
  .negative regulation of interleukin-8 secretion
.defense response to Gram-positive bacterium
.defense response to Gram-negative bacterium
  + 4 more...
.extracellular matrix binding
.laminin binding
.scavenger receptor activity
.fibronectin binding
.extracellular matrix
.membrane
.cytoplasm
  + 2 more...
2 EBI-359224,EBI-514941 CFLAR  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 20 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.death effector domain binding
.enzyme activator activity
.protease binding
.ripoptosome
.membrane raft
.CD95 death-inducing signaling complex
  + 3 more...
3 EBI-359224,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
4 EBI-359224,EBI-2880203 NEBL  
  .cardiac muscle thin filament assembly .actin filament binding
.filamin binding
.structural constituent of muscle
  + 2 more...
.extracellular exosome
.I band
.Z disc
.stress fiber
5 EBI-359224,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
6 EBI-359224,EBI-1053725 COX5B  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
7 EBI-359224,EBI-356254 SLC25A6  
  .regulation of insulin secretion
.active induction of host immune response by virus
.small molecule metabolic process
  + 9 more...
.ATP:ADP antiporter activity .integral component of membrane
.mitochondrial inner membrane presequence translocase complex
.mitochondrial inner membrane
  + 2 more...
8 EBI-359224,EBI-3893419 FOSL2  
  .response to cAMP
.response to corticosterone
.positive regulation of fibroblast proliferation
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.double-stranded DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
9 EBI-359224,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
10 EBI-359224,EBI-372273 PSMB1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
11 EBI-359224,EBI-2806671 GATA2  
  .regulation of forebrain neuron differentiation
.negative regulation of neural precursor cell proliferation
.GABAergic neuron differentiation
  + 29 more...
.C2H2 zinc finger domain binding
.zinc ion binding
.transcription factor binding
  + 5 more...
.protein complex
.nucleoplasm
12 EBI-359224,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
13 EBI-359224,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
14 EBI-359224,EBI-10206752 HOXD12  
  .embryonic digit morphogenesis
.pattern specification process
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding .transcription factor complex
.nucleus
15 EBI-359224,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
16 EBI-359224,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
17 EBI-359224,EBI-765407 BCL6  
  .negative regulation of cellular senescence
.positive regulation of cellular component movement
.regulation of immune response
  + 32 more...
.metal ion binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 4 more...
.nucleus
18 EBI-359224,EBI-711280 CDKN2B  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of protein serine/threonine kinase activity
.negative regulation of epithelial cell proliferation
  + 22 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
19 EBI-359224,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
20 EBI-359224,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
21 EBI-359224,EBI-749995 TCL1A  
  .stem cell maintenance
.multicellular organismal development
.N/A .pronucleus
.cell cortex
.endoplasmic reticulum
22 EBI-359224,EBI-10220734 GNG5  
  .cellular response to glucagon stimulus
.small molecule metabolic process
.synaptic transmission
  + 3 more...
.PDZ domain binding
.signal transducer activity
.GTPase activity
.extracellular exosome
.membrane
.plasma membrane
.heterotrimeric G-protein complex
23 EBI-359224,EBI-2514218 TFAP4  
  .positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cellular response to dexamethasone stimulus
.negative regulation of cell cycle arrest
  + 12 more...
.E-box binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 6 more...
.transcriptional repressor complex
.nucleus
24 EBI-359224,EBI-739737 EWSR1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleolus
  + 2 more...
25 EBI-359224,EBI-10222656 AKAP17A  
  .regulation of RNA splicing
.B cell activation
.RNA splicing
  + 3 more...
.protein kinase A binding
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.cytoplasm
.spliceosomal complex
  + 2 more...
26 EBI-359224,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
27 EBI-359224,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
28 EBI-359224,EBI-1642831 PDE4D  
  .negative regulation of relaxation of cardiac muscle
.regulation of cell communication by electrical coupling involved in cardiac conduction
.adrenergic receptor signaling pathway involved in positive regulation of heart rate
  + 29 more...
.scaffold protein binding
.ATPase binding
.metal ion binding
  + 8 more...
.calcium channel complex
.myofibril
.apical plasma membrane
  + 5 more...
29 EBI-359224,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
30 EBI-359224,EBI-711968 ECH1  
  .fatty acid beta-oxidation .isomerase activity
.receptor binding
.extracellular exosome
.membrane
.peroxisome
.mitochondrion
31 EBI-359224,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
32 EBI-359224,EBI-517709 BIRC3  
  .negative regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 27 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane raft
.protein complex
.cytosol
  + 3 more...
33 EBI-359224,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
34 EBI-359224,EBI-358507 RIPK1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 48 more...
.death domain binding
.identical protein binding
.protein complex binding
  + 5 more...
.ripoptosome
.membrane raft
.receptor complex
  + 4 more...
35 EBI-359224,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
36 EBI-359224,EBI-1046878 GIT2  
  .behavioral response to pain
.regulation of G-protein coupled receptor protein signaling pathway
.zinc ion binding
.GTPase activator activity
.focal adhesion
.nucleoplasm
37 EBI-359224,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
38 EBI-359224,EBI-2510602 JOSD1  
  .N/A .omega peptidase activity .membrane
.plasma membrane
.cytoplasm
39 EBI-359224,EBI-739717 MAPRE2  
  .cell division
.cell proliferation
.signal transduction
.mitotic nuclear division
.N/A .microtubule plus-end
.microtubule cytoskeleton
.cytoplasm
40 EBI-359224,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
41 EBI-359224,EBI-2798044 QRICH1  
  .N/A .N/A .nucleoplasm
42 EBI-359224,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
43 EBI-359224,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
44 EBI-359224,EBI-10241319 POM121L1P  
  .N/A .N/A .N/A
45 EBI-359224,EBI-10241513 PLEKHN1  
  .N/A .N/A .plasma membrane
46 EBI-359224,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
47 EBI-359224,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
48 EBI-359224,EBI-10188326 KIAA1217  
  .embryonic skeletal system development .N/A .cytoplasm
49 EBI-359224,EBI-10248148 -  
  .N/A .N/A .N/A
50 EBI-359224,EBI-744761 CYB5R2  
  .oxidation-reduction process
.sterol biosynthetic process
.cytochrome-b5 reductase activity, acting on NAD(P)H .membrane
.mitochondrion
.nucleus
51 EBI-359224,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
52 EBI-359224,EBI-10255155 ZNF662  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.metal ion binding
.transcription cofactor activity
.DNA binding
.nucleus
53 EBI-359224,EBI-10255185 SLC25A48  
  .transmembrane transport .N/A .integral component of membrane
.mitochondrial inner membrane
54 EBI-359224,EBI-2834978 DOK3  
  .Ras protein signal transduction .N/A .plasma membrane
.cytoplasm
55 EBI-359224,EBI-10225049 OLIG3  
  .spinal cord motor neuron migration
.spinal cord motor neuron cell fate specification
.DNA binding
.RNA polymerase II transcription corepressor activity
.nucleus
56 EBI-359224,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
57 EBI-359224,EBI-2512147 RBM45  
  .cell differentiation
.nervous system development
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleoplasm
.nucleus
58 EBI-359224,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
59 EBI-359224,EBI-726439 ZNF440  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
60 EBI-359224,EBI-744311 CCDC116  
  .N/A .N/A .centrosome
61 EBI-359224,EBI-6872807 SYCE1  
  .cell division
.synaptonemal complex assembly
.N/A .central element
62 EBI-359224,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
63 EBI-359224,EBI-747505 C1orf216  
  .N/A .N/A .N/A
64 EBI-359224,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
65 EBI-359224,EBI-2359040 DEPTOR  
  .regulation of extrinsic apoptotic signaling pathway
.negative regulation of cell size
.intracellular signal transduction
  + 2 more...
.N/A .intracellular
66 EBI-359224,EBI-10273699 ZNF502  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
67 EBI-359224,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
68 EBI-359224,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
69 EBI-359224,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
70 EBI-359224,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
71 EBI-359224,EBI-923440 GATAD2B  
  .ATP-dependent chromatin remodeling
.transcription, DNA-templated
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.protein complex
.nuclear speck
.nucleoplasm
.nuclear chromatin
72 EBI-359224,EBI-366525 POP5  
  .tRNA processing .ribonuclease P activity .nucleolar ribonuclease P complex
73 EBI-359224,EBI-745085 PHF21A  
  .chromatin modification
.blood coagulation
.regulation of transcription, DNA-templated
  + 4 more...
.zinc ion binding
.chromatin binding
.DNA binding
.nucleoplasm
.histone deacetylase complex
74 EBI-359224,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
75 EBI-359224,EBI-2350695 C5orf30  
  .cilium morphogenesis
.protein transport
.N/A .ciliary transition zone
.cytoplasm
76 EBI-359224,EBI-10185348 CCDC120  
  .N/A .N/A .N/A
77 EBI-359224,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
78 EBI-359224,EBI-8833163 LCOR  
  .transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
79 EBI-359224,EBI-1049952 ZNF512B  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
80 EBI-359224,EBI-1105153 PPP1R13B  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
.N/A .plasma membrane
.cytoplasm
.nucleoplasm
.nucleus
81 EBI-359224,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
82 EBI-359224,EBI-739534 CDCA3  
  .cell division
.protein ubiquitination
.mitotic nuclear division
.N/A .cytosol
83 EBI-359224,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
84 EBI-359224,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
85 EBI-359224,EBI-749118 WAC  
  .histone H2B conserved C-terminal lysine ubiquitination
.positive regulation of transcription, DNA-templated
.G1 DNA damage checkpoint
  + 5 more...
.chromatin binding
.RNA polymerase II core binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
.nucleus
86 EBI-359224,EBI-2811583 NUPL1  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.nuclear pore
.nuclear envelope
87 EBI-359224,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
88 EBI-359224,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
89 EBI-359224,EBI-749353 METTL17  
  .translation .methyltransferase activity
.copper ion binding
.ribosome
.mitochondrion
.nucleoplasm
.nucleus
90 EBI-359224,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
91 EBI-359224,EBI-2809489 A1CF  
  .protein stabilization
.mRNA modification
.cytidine to uridine editing
  + 2 more...
.single-stranded RNA binding
.RNA binding
.nucleotide binding
.apolipoprotein B mRNA editing enzyme complex
.endoplasmic reticulum
.cytoplasm
.nucleoplasm
92 EBI-359224,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
93 EBI-359224,EBI-10312471 PRDM7  
  .regulation of transcription, DNA-templated .histone-lysine N-methyltransferase activity
.nucleic acid binding
.chromosome
.nucleus
94 EBI-359224,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
95 EBI-359224,EBI-751617 FAM86C1  
  .N/A .methyltransferase activity .N/A
96 EBI-359224,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
97 EBI-359224,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
98 EBI-359224,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
99 EBI-359224,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
100 EBI-359224,EBI-10318831 MYEF2  
  .neuron differentiation
.myotube differentiation
.transcription, DNA-templated
.poly(A) RNA binding
.DNA binding
.nucleotide binding
.cytoplasm
.nucleoplasm
.nucleus
101 EBI-359224,EBI-750630 HEY2  
  .regulation of vasculogenesis
.negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
.negative regulation of cardiac vascular smooth muscle cell differentiation
  + 47 more...
.sequence-specific DNA binding
.histone deacetylase binding
.microsatellite binding
  + 5 more...
.transcriptional repressor complex
.cytoplasm
.nucleoplasm
.nucleus
102 EBI-359224,EBI-359444 RASAL2  
  .negative regulation of Ras protein signal transduction
.positive regulation of GTPase activity
.signal transduction
.GTPase activator activity .intrinsic component of the cytoplasmic side of the plasma membrane
.cytoplasm
103 EBI-359224,EBI-10326390 SIK3  
  .protein phosphorylation .ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
104 EBI-359224,EBI-718719 CARHSP1  
  .regulation of mRNA stability
.intracellular signal transduction
.regulation of transcription, DNA-templated
.phosphatase binding
.mRNA 3'-UTR binding
.DNA binding
.extracellular exosome
.P granule
.cytosol
.cytoplasmic mRNA processing body
105 EBI-359224,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
106 EBI-359224,EBI-717229 TSSC4  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood65
brain13
connective tissue33
embryonic tissue4
eye4
intestine25
kidney47
larynx127
lung68
lymph22
lymph node33
mammary gland59
mouth15
ovary19
skin33
stomach10
testis2
tonsil58
umbilical cord145
uterus8
Health State
TissuesTPM*
normal20
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor16
germ cell tumor18
glioma18
head and neck tumor29
kidney tumor14
leukemia63
lung tumor9
lymphoma41
non-neoplasia31
ovarian tumor26
skin tumor55
uterine tumor22
Developmental Stage
TissuesTPM*
adult26
embryoid body14
neonate64
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.8
adrenal gland4.8
appendix19.2
bone marrow5.1
cerebral cortex3.4
colon2.8
duodenum3.1
esophagus3.9
gallbladder7.7
heart muscle2.7
kidney2.9
liver1.7
lung6.6
lymph node29.8
ovary6.4
pancreas1.2
placenta2.1
prostate4.3
salivary gland3.4
skin5.7
small intestine3.6
spleen12.8
stomach5.6
testis2.2
thyroid gland3.1
urinary bladder8.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601711, gene) Tnf receptor-associated factor 1; TRAF1OMIM


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