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> Protein (NX_Q13123)
Protein (NX_Q13123)
Protein
Gene SymbolIK to neXtProt (NX_Q13123)
DescriptionProtein Red
Chromosome5
Location5q31.3 (140026643 ~ 140042064) to Ensembl
Sequene Features : Isoforms 1, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell-cell signaling
.immune response
.identical protein binding .nucleolus
.nucleoplasm
.extracellular space
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 48 9
2014-09-19protein level
1 36 9
2014-05-27protein level
1 36 9
2014-02-25protein level
1 36 8
2013-12-09protein level
1 28 8
2013-11-01protein level
1 27 8
2013-09-12protein level
1 27 8
2013-08-17protein level
1 27 8
2013-07-15protein level
1 18 5
2013-06-11protein level
1 18 5
2013-02-12protein level
1 6 8
2012-12-20protein level
1 6 8
2012-10-30protein level
1 6 8
2012-10-07protein level
1 6 8
2012-08-24protein level
1 5 8
2012-07-28protein level
1 5 8
2012-06-08protein level
1 7 8
2012-05-07protein level
1 5 8
2012-04-10protein level
1 5 8
2012-01-13protein level
1 8 8
2011-12-20protein level
1 8 8
2011-11-11protein level
1 8 6
2011-08-23protein level
1 8 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13123-1
20 0 0 65561.5794
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713456,EBI-448680 AURKA  
  .neuron projection extension
.positive regulation of oocyte maturation
.negative regulation of spindle checkpoint
  + 21 more...
.histone serine kinase activity
.protein kinase binding
.ATP binding
  + 3 more...
.meiotic spindle
.mitotic spindle
.spindle midzone
  + 14 more...
2 EBI-713456,EBI-2130294 RNF113A  
  .N/A .zinc ion binding .N/A
3 EBI-713456,EBI-536755 PRPF6  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.RNA splicing
  + 5 more...
.androgen receptor binding
.poly(A) RNA binding
.ribonucleoprotein complex binding
  + 2 more...
.catalytic step 2 spliceosome
.U4/U6 snRNP
.U4/U6 x U5 tri-snRNP complex
  + 6 more...
4 EBI-713456,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
5 EBI-713456,EBI-721525 RBM10  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding
.identical protein binding
.protein complex binding
  + 2 more...
.nucleoplasm
.nucleus
6 EBI-713456,EBI-357897 EFTUD2  
  .gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.GTP binding
.GTPase activity
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 4 more...
7 EBI-713456,EBI-298027 SMU1  
  .N/A .N/A .cytoplasm
.nucleus
8 EBI-713456,EBI-710176 FRA10AC1  
  .N/A .N/A .nucleus
9 EBI-713456,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
10 EBI-713456,EBI-749336 SNIP1  
  .positive regulation of protein targeting to mitochondrion
.production of miRNAs involved in gene silencing by miRNA
.I-kappaB kinase/NF-kappaB signaling
.regulation of transcription, DNA-templated
.poly(A) RNA binding .cytoplasm
.nucleoplasm
11 EBI-713456,EBI-3920997 ZNF830  
  .intestinal epithelial structure maintenance
.cell division
.chromosome organization
  + 4 more...
.metal ion binding .nuclear speck
.cytoplasm
.nucleoplasm
12 EBI-713456,EBI-295232 XAB2  
  .transcription, DNA-templated
.nucleotide-excision repair
.transcription-coupled nucleotide-excision repair
  + 3 more...
.N/A .catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland182
ascites276
bladder435
blood155
bone139
bone marrow205
brain199
cervix206
connective tissue194
embryonic tissue122
esophagus645
eye220
heart357
intestine163
kidney151
liver175
lung173
lymph248
lymph node55
mammary gland304
mouth60
muscle169
ovary216
pancreas98
parathyroid194
pharynx785
pituitary gland121
placenta134
prostate200
salivary gland148
skin246
spleen337
stomach188
testis264
thymus276
thyroid193
tonsil352
trachea38
umbilical cord217
uterus236
vascular154
Health State
TissuesTPM*
normal170
bladder carcinoma170
breast (mammary gland) tumor472
cervical tumor231
chondrosarcoma169
colorectal tumor168
esophageal tumor753
gastrointestinal tumor177
germ cell tumor129
glioma139
head and neck tumor89
kidney tumor304
leukemia105
liver tumor270
lung tumor165
lymphoma180
non-neoplasia258
ovarian tumor275
pancreatic tumor133
primitive neuroectodermal tumor of the CNS417
prostate cancer182
retinoblastoma452
skin tumor382
soft tissue/muscle tissue tumor239
uterine tumor255
Developmental Stage
TissuesTPM*
adult139
embryoid body57
blastocyst97
neonate193
fetus107
infant467
juvenile233
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.8
adrenal gland34.3
appendix38.8
bone marrow38.7
cerebral cortex28.3
colon33.7
duodenum28.6
esophagus35.6
gallbladder27.9
heart muscle28
kidney32.1
liver18.3
lung34.1
lymph node42.9
ovary35.1
pancreas10.8
placenta30.6
prostate32.1
salivary gland22.7
skin33
small intestine29.6
spleen37.5
stomach29.4
testis54.8
thyroid gland31.9
urinary bladder33.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600549, gene) Ik cytokine, downregulator of hla ii; IKOMIM


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