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> Protein (NX_Q13131)
Protein (NX_Q13131)
Protein
Gene SymbolPRKAA1 to neXtProt (NX_Q13131)
Description5'-AMP-activated protein kinase catalytic subunit alpha-1
Chromosome5
Location5p13.1 (40759481 ~ 40798476) to Ensembl
Sequene Features : Isoforms 2, Variants 33, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 33 14
2014-09-19protein level
2 35 14
2014-05-27protein level
2 35 14
2014-02-25protein level
2 23 14
2013-12-09protein level
2 16 14
2013-11-01protein level
2 16 14
2013-09-12protein level
2 16 16
2013-08-17protein level
2 16 16
2013-07-15protein level
2 2 16
2013-06-11protein level
2 2 16
2013-02-12protein level
2 2 56
2012-12-20protein level
2 2 56
2012-10-30protein level
2 4 56
2012-10-07protein level
2 4 28
2012-08-24protein level
2 4 28
2012-07-28protein level
2 4 28
2012-06-08protein level
2 11 28
2012-05-07protein level
2 11 28
2012-04-10protein level
2 11 28
2012-01-13protein level
2 13 28
2011-12-20protein level
2 13 28
2011-11-11protein level
2 13 28
2011-08-23protein level
2 12 26
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13131-1
0 21 3 63968.3751
NX_Q13131-2
1 21 3 65481.1854
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1181405,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-1181405,EBI-10181162 CDX4  
  .labyrinthine layer development
.positive regulation of transcription from RNA polymerase II promoter
.anterior/posterior pattern specification
  + 2 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
3 EBI-1181405,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
4 EBI-1181405,EBI-1059030 FSBP  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.identical protein binding .nucleus
5 EBI-1181405,EBI-740037 ZBED1  
  .metabolic process .metal ion binding
.transposase activity
.DNA binding
.nuclear chromosome
6 EBI-1181405,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
7 EBI-1181405,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
8 EBI-1181405,EBI-1181439 PRKAG1  
  .membrane organization
.protein heterooligomerization
.positive regulation of protein kinase activity
  + 12 more...
.ADP binding
.protein kinase binding
.AMP binding
  + 5 more...
.extracellular exosome
.AMP-activated protein kinase complex
.membrane
  + 2 more...
9 EBI-1181405,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
10 EBI-1181405,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
11 EBI-1181405,EBI-10171858 CTBP1  
  .negative regulation of transcription from RNA polymerase II promoter by histone modification
.negative regulation of histone H4 acetylation
.regulation of cell cycle
  + 9 more...
.repressing transcription factor binding
.NAD binding
.protein domain specific binding
  + 5 more...
.transcriptional repressor complex
.cytosol
.transcription factor complex
  + 2 more...
12 EBI-1181405,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
13 EBI-1181405,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
14 EBI-1181405,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
15 EBI-1181405,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-1181405,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
17 EBI-1181405,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
18 EBI-1181405,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
19 EBI-1181405,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
20 EBI-1181405,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
21 EBI-1181405,EBI-769401 INO80E  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA recombination
  + 2 more...
.N/A .Ino80 complex
.nucleolus
.nucleoplasm
.nucleus
22 EBI-1181405,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
23 EBI-1181405,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
24 EBI-1181405,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
25 EBI-1181405,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
26 EBI-1181405,EBI-1378139 ROPN1  
  .small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
27 EBI-1181405,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
28 EBI-1181405,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
29 EBI-1181405,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
30 EBI-1181405,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
31 EBI-1181405,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
32 EBI-1181405,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
33 EBI-1181405,EBI-719769 PRKAB1  
  .membrane organization
.protein heterooligomerization
.regulation of protein kinase activity
  + 10 more...
.AMP-activated protein kinase activity
.protein kinase activity
.AMP-activated protein kinase complex
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites75
bladder33
blood81
bone27
bone marrow20
brain33
cervix82
connective tissue13
ear186
embryonic tissue51
esophagus99
eye4
intestine25
kidney42
larynx127
liver73
lung50
lymph45
lymph node22
mammary gland92
mouth120
muscle103
nerve128
ovary29
pancreas37
parathyroid339
placenta52
prostate116
salivary gland49
skin33
spleen56
stomach20
testis89
thymus62
thyroid42
trachea579
uterus81
vascular135
Health State
TissuesTPM*
normal49
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor115
chondrosarcoma24
colorectal tumor26
esophageal tumor115
gastrointestinal tumor42
germ cell tumor53
glioma27
head and neck tumor97
kidney tumor29
leukemia74
liver tumor20
lung tumor29
lymphoma41
ovarian tumor39
pancreatic tumor47
prostate cancer173
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor77
Developmental Stage
TissuesTPM*
adult64
embryoid body42
neonate64
fetus34
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue37.1
adrenal gland26.9
appendix44.8
bone marrow55.8
cerebral cortex16
colon40.4
duodenum40.9
esophagus30.4
gallbladder47
heart muscle23.6
kidney34.6
liver32.8
lung35.9
lymph node38.3
ovary28.4
pancreas16.8
placenta25.2
prostate37.1
salivary gland28.6
skin25.9
small intestine40.9
spleen34.9
stomach43.8
testis62
thyroid gland42.5
urinary bladder43.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Low
skin 2Low
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602739, gene) Protein kinase, amp-activated, catalytic, alpha-1; PRKAA1OMIM


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