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> Protein (NX_Q13136)
Protein (NX_Q13136)
Protein
Gene SymbolPPFIA1 to neXtProt (NX_Q13136)
DescriptionLiprin-alpha-1
Chromosome11
Location11q13.3 (70116806 ~ 70230509) to Ensembl
Sequene Features : Isoforms 2, Variants 147, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of establishment of protein localization to plasma membrane
.negative regulation of stress fiber assembly
.glutamate secretion
  + 4 more...
.signal transducer activity .presynaptic active zone
.focal adhesion
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 147 18
2014-09-19protein level
2 118 18
2014-05-27protein level
2 118 18
2014-02-25protein level
2 118 18
2013-12-09protein level
2 97 18
2013-11-01protein level
2 95 18
2013-09-12protein level
2 95 18
2013-08-17protein level
2 95 18
2013-07-15protein level
2 76 18
2013-06-11protein level
2 76 18
2013-02-12protein level
2 39 30
2012-12-20protein level
2 36 30
2012-10-30protein level
2 41 30
2012-10-07protein level
2 41 15
2012-08-24protein level
2 38 15
2012-07-28protein level
2 38 15
2012-06-08protein level
2 47 15
2012-05-07protein level
2 33 15
2012-04-10protein level
2 33 15
2012-01-13protein level
2 23 15
2011-12-20protein level
2 23 15
2011-11-11protein level
2 23 14
2011-08-23protein level
2 23 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13136-1
1 36 11 135694.6064
NX_Q13136-2
0 36 11 133886.7304
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745426,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
2 EBI-745426,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
3 EBI-745426,EBI-741406 CCNH  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 20 more...
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.TFIIK complex
.cyclin-dependent protein kinase activating kinase holoenzyme complex
.holo TFIIH complex
  + 2 more...
4 EBI-745426,EBI-396563 PPP2R5D  
  .canonical glycolysis
.stress-activated MAPK cascade
.neurotrophin TRK receptor signaling pathway
  + 20 more...
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.cytosol
.nucleoplasm
.nucleus
.protein phosphatase type 2A complex
5 EBI-745426,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
6 EBI-745426,EBI-741953 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder66
blood24
bone97
brain29
cervix123
connective tissue60
embryonic tissue46
esophagus49
eye67
heart33
intestine4
kidney18
larynx170
liver38
lung2
lymph22
lymph node66
mammary gland59
mouth90
muscle9
nerve128
pancreas4
pharynx49
placenta60
prostate5
skin90
spleen18
stomach10
testis87
thymus62
thyroid85
trachea19
uterus56
vascular38
Health State
TissuesTPM*
normal47
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor173
chondrosarcoma120
colorectal tumor8
esophageal tumor57
gastrointestinal tumor8
germ cell tumor41
glioma27
head and neck tumor112
kidney tumor29
leukemia31
liver tumor31
lung tumor29
lymphoma41
non-neoplasia72
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma64
skin tumor87
soft tissue/muscle tissue tumor39
uterine tumor99
Developmental Stage
TissuesTPM*
adult2
embryoid body85
blastocyst65
neonate32
fetus1
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.9
adrenal gland18.3
appendix18.9
bone marrow18.3
cerebral cortex25.4
colon19.4
duodenum15.4
esophagus20.5
gallbladder29.2
heart muscle17.9
kidney21.5
liver11.7
lung22.2
lymph node18
ovary20.5
pancreas9.6
placenta26.2
prostate16.7
salivary gland12
skin19.8
small intestine16.9
spleen16.4
stomach15.4
testis57.6
thyroid gland34.3
urinary bladder22.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611054, gene) Protein-tyrosine phosphatase, receptor-type, f polypeptide-interactingOMIM


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