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> Protein (NX_Q13153)
Protein (NX_Q13153)
Protein
Gene SymbolPAK1 to neXtProt (NX_Q13153)
DescriptionSerine/threonine-protein kinase PAK 1
Chromosome11
Location11q13.5 (77032752 ~ 77185680) to Ensembl
Sequene Features : Isoforms 2, Variants 53, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell proliferation involved in contact inhibition
.positive regulation of stress fiber assembly
.T cell receptor signaling pathway
  + 32 more...
.Rac GTPase binding
.ATP binding
.collagen binding
  + 2 more...
.protein complex
.ruffle membrane
.nuclear membrane
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 53 24
2014-09-19protein level
2 39 24
2014-05-27protein level
2 39 25
2014-02-25protein level
2 39 25
2013-12-09protein level
2 37 25
2013-11-01protein level
2 36 25
2013-09-12protein level
2 36 25
2013-08-17protein level
2 36 25
2013-07-15protein level
2 27 24
2013-06-11protein level
2 27 24
2013-02-12protein level
2 9 52
2012-12-20protein level
2 9 52
2012-10-30protein level
2 10 40
2012-10-07protein level
2 10 20
2012-08-24protein level
2 6 20
2012-07-28protein level
2 6 20
2012-06-08protein level
2 14 20
2012-05-07protein level
2 14 20
2012-04-10protein level
2 14 20
2012-01-13protein level
2 16 20
2011-12-20protein level
2 16 20
2011-11-11protein level
2 16 21
2011-08-23protein level
2 16 21
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13153-1
2 13 10 60608.5649
NX_Q13153-2
1 13 10 61592.75
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1307,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-1307,EBI-1298 CDK11B  
  .regulation of mRNA processing
.cell proliferation
.mitotic nuclear division
  + 4 more...
.poly(A) RNA binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
  + 2 more...
.cytoplasm
.nucleus
3 EBI-1307,EBI-444403 LIMK1  
  .positive regulation of stress fiber assembly
.negative regulation of ubiquitin-protein transferase activity
.ephrin receptor signaling pathway
  + 11 more...
.heat shock protein binding
.zinc ion binding
.ATP binding
  + 2 more...
.neuron projection
.focal adhesion
.cytosol
  + 2 more...
4 EBI-1307,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
5 EBI-1307,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
6 EBI-1307,EBI-717515 ARHGEF7  
  .positive regulation of lamellipodium morphogenesis
.positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
  + 14 more...
.protein kinase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.protein complex
.neuronal cell body
.neuron projection
  + 5 more...
7 EBI-1019502,EBI-1638043 RHOU  
  .positive regulation of protein targeting to mitochondrion
.regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
  + 5 more...
.metal ion binding
.GTP binding
.GTPase activity
.cell projection
.focal adhesion
.plasma membrane
  + 3 more...
8 EBI-1307,EBI-1205846 CRIPAK  
  .regulation of cytoskeleton organization
.response to estrogen
.negative regulation of intracellular estrogen receptor signaling pathway
.negative regulation of protein kinase activity
.N/A .plasma membrane
.endoplasmic reticulum
.cytoplasm
.nucleus
9 EBI-1307,EBI-466061 GIT1  
  .ephrin receptor signaling pathway
.regulation of cytokinesis
.regulation of G-protein coupled receptor protein signaling pathway
.axon guidance
.zinc ion binding
.GTPase activator activity
.aggresome
.membrane
.focal adhesion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites75
blood65
bone27
bone marrow61
brain58
cervix41
connective tissue462
embryonic tissue56
esophagus49
eye28
heart11
intestine94
kidney61
liver14
lung29
mammary gland132
mouth438
muscle47
ovary88
pancreas56
parathyroid97
pharynx24
pituitary gland121
placenta52
prostate26
skin14
spleen18
stomach73
testis25
thymus75
thyroid128
uterus47
vascular38
Health State
TissuesTPM*
normal47
bladder carcinoma56
breast (mammary gland) tumor214
cervical tumor57
chondrosarcoma24
colorectal tumor133
esophageal tumor57
gastrointestinal tumor67
germ cell tumor56
glioma9
head and neck tumor239
kidney tumor87
leukemia63
lung tumor68
non-neoplasia31
ovarian tumor91
pancreatic tumor66
primitive neuroectodermal tumor of the CNS7
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor558
uterine tumor44
Developmental Stage
TissuesTPM*
adult113
embryoid body28
blastocyst113
neonate64
fetus52
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.9
adrenal gland16.2
appendix42.1
bone marrow43.6
cerebral cortex105.5
colon43.5
duodenum46
esophagus24.1
gallbladder38.2
heart muscle7.9
kidney22.3
liver10.9
lung16.2
lymph node24.5
ovary27.5
pancreas11.8
placenta27.5
prostate19.6
salivary gland16.2
skin18.8
small intestine54
spleen34.4
stomach48.6
testis37.9
thyroid gland41.3
urinary bladder30.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1High
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602590, gene) p21 protein-activated kinase 1; PAK1OMIM


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