Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q13158)
Protein (NX_Q13158)
Protein
Gene SymbolFADD to neXtProt (NX_Q13158)
DescriptionFAS-associated death domain protein
Chromosome11
Location11q13.3 (70049269 ~ 70053496) to Ensembl
Sequene Features : Isoforms 1, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 49 more...
.identical protein binding
.death effector domain binding
.tumor necrosis factor receptor superfamily binding
  + 2 more...
.ripoptosome
.membrane raft
.cell body
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 14 2
2014-09-19protein level
1 14 2
2014-05-27protein level
1 14 2
2014-02-25protein level
1 15 2
2013-12-09protein level
1 13 2
2013-11-01protein level
1 13 2
2013-09-12protein level
1 13 2
2013-08-17protein level
1 13 2
2013-07-15protein level
1 9 2
2013-06-11protein level
1 9 2
2013-02-12protein level
1 6 5
2012-12-20protein level
1 6 5
2012-10-30protein level
1 6 5
2012-10-07protein level
1 6 5
2012-08-24protein level
1 6 5
2012-07-28protein level
1 6 5
2012-06-08protein level
1 22 5
2012-05-07protein level
1 19 5
2012-04-10protein level
1 19 5
2012-01-13protein level
1 19 5
2011-12-20protein level
1 19 5
2011-11-11protein level
1 19 5
2011-08-23protein level
1 19 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13158-1
6 0 0 23264.778
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-494804,EBI-348011 MBD4  
  .depyrimidination
.response to radiation
.intrinsic apoptotic signaling pathway in response to DNA damage
  + 4 more...
.pyrimidine-specific mismatch base pair DNA N-glycosylase activity
.endodeoxyribonuclease activity
.satellite DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.chromatin
2 EBI-494804,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
3 EBI-494804,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
4 EBI-494804,EBI-476768 PLK1  
  .regulation of mitotic spindle assembly
.protein localization to chromatin
.regulation of cell cycle
  + 36 more...
.protein kinase binding
.kinase activity
.anaphase-promoting complex binding
  + 4 more...
.spindle midzone
.midbody
.microtubule cytoskeleton
  + 10 more...
5 EBI-494804,EBI-358507 RIPK1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 48 more...
.death domain binding
.identical protein binding
.protein complex binding
  + 5 more...
.ripoptosome
.membrane raft
.receptor complex
  + 4 more...
6 EBI-494804,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
7 EBI-494804,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
8 EBI-494804,EBI-1164361 PARK7  
  .negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of androgen receptor activity
  + 69 more...
.glyoxalase (glycolic acid-forming) activity
.ubiquitin-specific protease binding
.cuprous ion binding
  + 24 more...
.extracellular exosome
.membrane raft
.cell body
  + 10 more...
9 EBI-494804,EBI-447677 MYD88  
  .cellular response to mechanical stimulus
.3'-UTR-mediated mRNA stabilization
.response to interleukin-1
  + 22 more...
.TIR domain binding
.identical protein binding
.death receptor binding
.endosome membrane
.plasma membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder33
blood57
bone69
brain28
cervix144
connective tissue13
embryonic tissue61
esophagus49
eye76
heart22
intestine56
kidney61
larynx85
liver43
lung92
lymph90
lymph node22
mammary gland66
mouth15
muscle9
ovary68
pancreas126
parathyroid194
pharynx24
pituitary gland60
placenta84
prostate21
salivary gland246
skin132
spleen37
stomach73
testis43
thymus25
thyroid85
trachea19
uterus43
vascular77
Health State
TissuesTPM*
normal43
breast (mammary gland) tumor107
cervical tumor28
chondrosarcoma24
colorectal tumor53
gastrointestinal tumor84
germ cell tumor45
glioma65
head and neck tumor97
kidney tumor72
leukemia52
liver tumor62
lung tumor155
lymphoma83
non-neoplasia41
ovarian tumor65
pancreatic tumor219
primitive neuroectodermal tumor of the CNS220
prostate cancer28
retinoblastoma86
skin tumor159
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult50
embryoid body42
blastocyst65
neonate32
fetus39
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.1
adrenal gland8.1
appendix10
bone marrow3.7
cerebral cortex4.3
colon12.5
duodenum8.2
esophagus7.6
gallbladder10.8
heart muscle4.9
kidney12.7
liver7.7
lung8.5
lymph node12.2
ovary8.6
pancreas2.8
placenta11.1
prostate7
salivary gland6.2
skin8
small intestine8.9
spleen9.3
stomach12.2
testis5.2
thyroid gland9.6
urinary bladder10.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bronchusLow
cerebral cortexMedium
cervix, uterineMedium
colonLow
endometrium 2Low
epididymisMedium
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
lungMedium
lymph nodeLow
nasopharynxMedium
pancreasLow
placentaMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineLow
spleenLow
stomach 1Medium
stomach 2Low
testisLow
thyroid glandLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602457, gene) Fas-associated via death domain; FADDOMIM
2(#613759, phenotype) Infections, recurrent, with encephalopathy, hepatic dysfunction, andOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center