Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q13177)
Protein (NX_Q13177)
Protein
Gene SymbolPAK2 to neXtProt (NX_Q13177)
DescriptionSerine/threonine-protein kinase PAK 2
Chromosome3
Location3q29 (196466728 ~ 196559518) to Ensembl
Sequene Features : Isoforms 1, Variants 64, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 64 20
2014-09-19protein level
1 43 20
2014-05-27protein level
1 43 22
2014-02-25protein level
1 42 22
2013-12-09protein level
1 37 22
2013-11-01protein level
1 35 19
2013-09-12protein level
1 35 19
2013-08-17protein level
1 35 19
2013-07-15protein level
1 25 16
2013-06-11protein level
1 25 16
2013-02-12protein level
1 8 13
2012-12-20protein level
1 8 13
2012-10-30protein level
1 8 13
2012-10-07protein level
1 8 13
2012-08-24protein level
1 7 13
2012-07-28protein level
1 7 13
2012-06-08protein level
1 20 13
2012-05-07protein level
1 15 13
2012-04-10protein level
1 15 13
2012-01-13protein level
1 17 13
2011-12-20protein level
1 17 13
2011-11-11protein level
1 17 13
2011-08-23protein level
1 17 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13177-1
18 0 8 58005.718
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1045887,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
2 EBI-1045887,EBI-311323 SORBS2  
  .cell migration
.cell adhesion
.actin filament organization
.metal ion binding
.poly(A) RNA binding
.structural constituent of muscle
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.actin cytoskeleton
  + 2 more...
3 EBI-1045887,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
4 EBI-1045887,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
5 EBI-1045887,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
6 EBI-1045887,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
7 EBI-1045887,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
8 EBI-1045887,EBI-444403 LIMK1  
  .positive regulation of stress fiber assembly
.negative regulation of ubiquitin-protein transferase activity
.ephrin receptor signaling pathway
  + 11 more...
.heat shock protein binding
.zinc ion binding
.ATP binding
  + 2 more...
.neuron projection
.focal adhesion
.cytosol
  + 2 more...
9 EBI-1045887,EBI-523958 CASP7  
  .execution phase of apoptosis
.intrinsic apoptotic signaling pathway
.programmed cell death
  + 4 more...
.cysteine-type endopeptidase activity involved in execution phase of apoptosis
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-1045887,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
11 EBI-1045887,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
12 EBI-1045887,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
13 EBI-1045887,EBI-717515 ARHGEF7  
  .positive regulation of lamellipodium morphogenesis
.positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
  + 14 more...
.protein kinase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.protein complex
.neuronal cell body
.neuron projection
  + 5 more...
14 EBI-1045887,EBI-1642523 ARHGEF6  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 7 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.lamellipodium
.cell-cell junction
.cytosol
.intracellular
15 EBI-1045887,EBI-7975674 SH3RF3  
  .N/A .zinc ion binding .N/A
16 EBI-1045887,EBI-433642 SORBS1  
  .positive regulation of establishment of protein localization to plasma membrane
.focal adhesion assembly
.positive regulation of lipid biosynthetic process
  + 9 more...
.cytoskeletal protein binding
.insulin receptor binding
.SH3/SH2 adaptor activity
.actin binding
.membrane raft
.nuclear matrix
.focal adhesion
  + 10 more...
17 EBI-1045887,EBI-6285694 RHOJ  
  .retina vasculature morphogenesis in camera-type eye
.regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
  + 4 more...
.GTP binding
.GTPase activity
.extracellular exosome
.plasma membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder167
blood65
bone69
bone marrow123
brain53
cervix82
connective tissue40
ear124
embryonic tissue93
esophagus49
eye38
heart78
intestine86
kidney66
liver48
lung65
lymph22
lymph node144
mammary gland125
mouth151
muscle103
ovary29
pancreas60
parathyroid242
pharynx270
placenta45
prostate73
skin90
spleen56
stomach83
testis39
thymus62
thyroid85
trachea57
uterus99
vascular38
Health State
TissuesTPM*
normal61
bladder carcinoma113
breast (mammary gland) tumor107
cervical tumor86
chondrosarcoma72
colorectal tumor106
esophageal tumor57
gastrointestinal tumor84
germ cell tumor72
glioma83
head and neck tumor164
kidney tumor29
leukemia148
liver tumor83
lung tumor77
lymphoma27
non-neoplasia51
ovarian tumor26
pancreatic tumor85
primitive neuroectodermal tumor of the CNS62
prostate cancer28
retinoblastoma21
skin tumor79
soft tissue/muscle tissue tumor79
uterine tumor122
Developmental Stage
TissuesTPM*
adult90
embryoid body114
blastocyst97
neonate64
fetus73
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.6
adrenal gland16.7
appendix30.6
bone marrow12.6
cerebral cortex16.8
colon21.1
duodenum17.7
esophagus19.7
gallbladder22.1
heart muscle16
kidney16.3
liver14.9
lung20.2
lymph node33.7
ovary16.6
pancreas7.4
placenta24.7
prostate16.5
salivary gland9.3
skin12.5
small intestine18.4
spleen33.5
stomach17.8
testis13.6
thyroid gland16.9
urinary bladder26.3
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
breastLow
bronchusMedium
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
esophagusLow
fallopian tubeLow
gallbladderMedium
kidneyLow
liverMedium
lungLow
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
ovaryLow
parathyroid glandLow
placentaLow
rectumMedium
salivary glandLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
spleenMedium
stomach 1Low
stomach 2Low
thyroid glandLow
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605022, gene) p21 protein-activated kinase 2; PAK2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center