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	> Protein (NX_Q13177) Protein (NX_Q13177) Protein Gene Symbol PAK2 to neXtProt (NX_Q13177) Description Serine/threonine-protein kinase PAK 2 Chromosome 3 Location 3q29 (196466728 ~ 196559518) to Ensembl Sequene Features : Isoforms 1, Variants 64, PTMs 20 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis .positive regulation of extrinsic apoptotic signaling pathway .positive regulation of protein tyrosine kinase activity   + 30 more... .Rac GTPase binding .identical protein binding .protein tyrosine kinase activator activity   + 4 more... .perinuclear region of cytoplasm .plasma membrane .cytosol   + 2 more... Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 1 64 20 2014-09-19 protein level 1 43 20 2014-05-27 protein level 1 43 22 2014-02-25 protein level 1 42 22 2013-12-09 protein level 1 37 22 2013-11-01 protein level 1 35 19 2013-09-12 protein level 1 35 19 2013-08-17 protein level 1 35 19 2013-07-15 protein level 1 25 16 2013-06-11 protein level 1 25 16 2013-02-12 protein level 1 8 13 2012-12-20 protein level 1 8 13 2012-10-30 protein level 1 8 13 2012-10-07 protein level 1 8 13 2012-08-24 protein level 1 7 13 2012-07-28 protein level 1 7 13 2012-06-08 protein level 1 20 13 2012-05-07 protein level 1 15 13 2012-04-10 protein level 1 15 13 2012-01-13 protein level 1 17 13 2011-12-20 protein level 1 17 13 2011-11-11 protein level 1 17 13 2011-08-23 protein level 1 17 13 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q13177-1 18 0 8 58005.718 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-1045887,EBI-741237 SORBS3     .positive regulation of stress fiber assembly .positive regulation of cytoskeleton organization .positive regulation of MAPK cascade   + 5 more... .vinculin binding .structural constituent of cytoskeleton .focal adhesion .cytoskeleton .cytosol .nucleus 2 EBI-1045887,EBI-311323 SORBS2     .cell migration .cell adhesion .actin filament organization .metal ion binding .poly(A) RNA binding .structural constituent of muscle   + 2 more... .perinuclear region of cytoplasm .Z disc .actin cytoskeleton   + 2 more... 3 EBI-1045887,EBI-365996 RAF1     .regulation of cell motility .negative regulation of extrinsic apoptotic signaling pathway via death domain receptors .death-inducing signaling complex assembly   + 36 more... .metal ion binding .identical protein binding .ATP binding   + 3 more... .pseudopodium .plasma membrane .cytosol   + 4 more... 4 EBI-1045887,EBI-346340 HCK     .positive regulation of actin cytoskeleton reorganization .regulation of podosome assembly .cellular response to peptide hormone stimulus   + 28 more... .ATP binding .receptor binding .non-membrane spanning protein tyrosine kinase activity .protein tyrosine kinase activity .cell projection .extrinsic component of cytoplasmic side of plasma membrane .transport vesicle   + 7 more... 5 EBI-1045887,EBI-621482 SRC     .regulation of caveolin-mediated endocytosis .negative regulation of intrinsic apoptotic signaling pathway .negative regulation of extrinsic apoptotic signaling pathway   + 100 more... .scaffold protein binding .growth factor receptor binding .hormone receptor binding   + 14 more... .extracellular exosome .perinuclear region of cytoplasm .neuron projection   + 13 more... 6 EBI-1045887,EBI-389883 NCK1     .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation .negative regulation of PERK-mediated unfolded protein response   + 23 more... .eukaryotic initiation factor eIF2 binding .receptor tyrosine kinase binding .protein binding, bridging   + 5 more... .vesicle membrane .cell-cell junction .plasma membrane   + 6 more... 7 EBI-1045887,EBI-466029 HTT     .negative regulation of extrinsic apoptotic signaling pathway .iron ion homeostasis .L-glutamate import   + 38 more... .diazepam binding .beta-tubulin binding .dynein intermediate chain binding   + 6 more... .protein complex .cytoplasmic vesicle membrane .dendrite   + 11 more... 8 EBI-1045887,EBI-444403 LIMK1     .positive regulation of stress fiber assembly .negative regulation of ubiquitin-protein transferase activity .ephrin receptor signaling pathway   + 11 more... .heat shock protein binding .zinc ion binding .ATP binding   + 2 more... .neuron projection .focal adhesion .cytosol   + 2 more... 9 EBI-1045887,EBI-523958 CASP7     .execution phase of apoptosis .intrinsic apoptotic signaling pathway .programmed cell death   + 4 more... .cysteine-type endopeptidase activity involved in execution phase of apoptosis .cysteine-type peptidase activity .cysteine-type endopeptidase activity .cytosol .cytoplasm .nucleoplasm .nucleus 10 EBI-1045887,EBI-81752 CDC42     .positive regulation of substrate adhesion-dependent cell spreading .positive regulation of intracellular protein transport .epithelial cell-cell adhesion   + 61 more... .identical protein binding .apolipoprotein A-I receptor binding .thioesterase binding   + 3 more... .mitotic spindle .extracellular exosome .spindle midzone   + 17 more... 11 EBI-1045887,EBI-401755 GRB2     .positive regulation of reactive oxygen species metabolic process .cellular response to ionizing radiation .branching involved in labyrinthine layer morphogenesis   + 25 more... .ephrin receptor binding .poly(A) RNA binding .insulin receptor substrate binding   + 6 more... .Grb2-EGFR complex .extracellular exosome .vesicle membrane   + 10 more... 12 EBI-1045887,EBI-413628 RAC1     .positive regulation of substrate adhesion-dependent cell spreading .apoptotic signaling pathway .ruffle assembly   + 63 more... .Rho GDP-dissociation inhibitor binding .thioesterase binding .enzyme binding   + 2 more... .extracellular exosome .melanosome .cytoplasmic ribonucleoprotein granule   + 12 more... 13 EBI-1045887,EBI-717515 ARHGEF7     .positive regulation of lamellipodium morphogenesis .positive regulation of substrate adhesion-dependent cell spreading .apoptotic signaling pathway   + 14 more... .protein kinase binding .Rho guanyl-nucleotide exchange factor activity .guanyl-nucleotide exchange factor activity .protein complex .neuronal cell body .neuron projection   + 5 more... 14 EBI-1045887,EBI-1642523 ARHGEF6     .apoptotic signaling pathway .regulation of small GTPase mediated signal transduction .neurotrophin TRK receptor signaling pathway   + 7 more... .GTPase activator activity .Rho guanyl-nucleotide exchange factor activity .lamellipodium .cell-cell junction .cytosol .intracellular 15 EBI-1045887,EBI-7975674 SH3RF3     .N/A .zinc ion binding .N/A 16 EBI-1045887,EBI-433642 SORBS1     .positive regulation of establishment of protein localization to plasma membrane .focal adhesion assembly .positive regulation of lipid biosynthetic process   + 9 more... .cytoskeletal protein binding .insulin receptor binding .SH3/SH2 adaptor activity .actin binding .membrane raft .nuclear matrix .focal adhesion   + 10 more... 17 EBI-1045887,EBI-6285694 RHOJ     .retina vasculature morphogenesis in camera-type eye .regulation of small GTPase mediated signal transduction .actin cytoskeleton organization   + 4 more... .GTP binding .GTPase activity .extracellular exosome .plasma membrane .cytosol EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* ascites 100 bladder 167 blood 65 bone 69 bone marrow 123 brain 53 cervix 82 connective tissue 40 ear 124 embryonic tissue 93 esophagus 49 eye 38 heart 78 intestine 86 kidney 66 liver 48 lung 65 lymph 22 lymph node 144 mammary gland 125 mouth 151 muscle 103 ovary 29 pancreas 60 parathyroid 242 pharynx 270 placenta 45 prostate 73 skin 90 spleen 56 stomach 83 testis 39 thymus 62 thyroid 85 trachea 57 uterus 99 vascular 38 Health State Tissues TPM* normal 61 bladder carcinoma 113 breast (mammary gland) tumor 107 cervical tumor 86 chondrosarcoma 72 colorectal tumor 106 esophageal tumor 57 gastrointestinal tumor 84 germ cell tumor 72 glioma 83 head and neck tumor 164 kidney tumor 29 leukemia 148 liver tumor 83 lung tumor 77 lymphoma 27 non-neoplasia 51 ovarian tumor 26 pancreatic tumor 85 primitive neuroectodermal tumor of the CNS 62 prostate cancer 28 retinoblastoma 21 skin tumor 79 soft tissue/muscle tissue tumor 79 uterine tumor 122 Developmental Stage Tissues TPM* adult 90 embryoid body 114 blastocyst 97 neonate 64 fetus 73 juvenile 161 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 22.6 adrenal gland 16.7 appendix 30.6 bone marrow 12.6 cerebral cortex 16.8 colon 21.1 duodenum 17.7 esophagus 19.7 gallbladder 22.1 heart muscle 16 kidney 16.3 liver 14.9 lung 20.2 lymph node 33.7 ovary 16.6 pancreas 7.4 placenta 24.7 prostate 16.5 salivary gland 9.3 skin 12.5 small intestine 18.4 spleen 33.5 stomach 17.8 testis 13.6 thyroid gland 16.9 urinary bladder 26.3 Tissues Tissues Expression level adrenal gland Low appendix Medium breast Low bronchus Medium cerebral cortex Low cervix, uterine Medium colon Medium duodenum Medium endometrium 1 Low endometrium 2 Medium esophagus Low fallopian tube Low gallbladder Medium kidney Low liver Medium lung Low lymph node High nasopharynx Medium oral mucosa Low ovary Low parathyroid gland Low placenta Low rectum Medium salivary gland Low skeletal muscle Low skin 1 Medium skin 2 Medium small intestine Medium spleen Medium stomach 1 Low stomach 2 Low thyroid gland Low tonsil Medium Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*605022, gene) p21 protein-activated kinase 2; PAK2 OMIM

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