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> Protein (NX_Q13185)
Protein (NX_Q13185)
Protein
Gene SymbolCBX3 to neXtProt (NX_Q13185)
DescriptionChromobox protein homolog 3
Chromosome7
Location7p15.2 (26240782 ~ 26252976) to Ensembl
Sequene Features : Isoforms 1, Variants 17, PTMs 21 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.rhythmic process
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin remodeling
.histone methyltransferase binding
.identical protein binding
.protein domain specific binding
.enzyme binding
.nuclear pericentric heterochromatin
.spindle
.nuclear heterochromatin
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 17 21
2014-09-19protein level
1 15 21
2014-05-27protein level
1 15 21
2014-02-25protein level
1 15 19
2013-12-09protein level
1 15 19
2013-11-01protein level
1 15 17
2013-09-12protein level
1 15 17
2013-08-17protein level
1 15 17
2013-07-15protein level
1 11 10
2013-06-11protein level
1 11 10
2013-02-12protein level
1 4 9
2012-12-20protein level
1 4 9
2012-10-30protein level
1 4 9
2012-10-07protein level
1 4 9
2012-08-24protein level
1 4 9
2012-07-28protein level
1 4 9
2012-06-08protein level
1 7 9
2012-05-07protein level
1 4 9
2012-04-10protein level
1 4 9
2012-01-13protein level
1 4 9
2011-12-20protein level
1 4 9
2011-11-11protein level
1 4 9
2011-08-23protein level
1 4 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13185-1
5 0 2 20798.2906
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-78176,EBI-79722 HIST1H3A  
  .regulation of gene silencing
.protein heterotetramerization
.negative regulation of gene expression, epigenetic
  + 10 more...
.histone binding
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 6 more...
2 EBI-78176,EBI-78139 TRIM28  
  .regulation of genetic imprinting
.negative regulation of viral release from host cell
.negative regulation of DNA demethylation
  + 18 more...
.chromo shadow domain binding
.poly(A) RNA binding
.sequence-specific DNA binding
  + 10 more...
.RNA polymerase II transcription factor complex
.nuclear heterochromatin
.nuclear euchromatin
  + 2 more...
3 EBI-78176,EBI-1055147 LBR  
  .small molecule metabolic process
.cholesterol biosynthetic process
.chromo shadow domain binding
.poly(A) RNA binding
.oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
  + 2 more...
.nuclear membrane
.integral component of membrane
.membrane
  + 2 more...
4 EBI-78176,EBI-7960569 SUV420H2  
  .histone H4-K20 trimethylation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.histone methyltransferase activity (H4-K20 specific) .pericentric heterochromatin
.nuclear heterochromatin
.nucleoplasm
.condensed nuclear chromosome, centromeric region
5 EBI-78176,EBI-1764854 ADNP  
  .negative regulation of neuron apoptotic process
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.chromatin binding
.DNA binding
.nucleus
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland242
ascites251
bladder368
blood81
bone125
bone marrow287
brain78
cervix61
connective tissue33
ear372
embryonic tissue277
eye158
heart156
intestine150
kidney161
larynx85
liver131
lung110
lymph180
lymph node233
mammary gland52
mouth30
muscle94
nerve257
ovary147
pancreas65
parathyroid242
pharynx171
placenta180
prostate131
salivary gland98
skin175
spleen74
stomach135
testis195
thymus25
umbilical cord581
uterus215
vascular19
Health State
TissuesTPM*
normal122
adrenal tumor316
bladder carcinoma909
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma120
colorectal tumor133
gastrointestinal tumor177
germ cell tumor178
glioma37
head and neck tumor14
kidney tumor319
leukemia243
liver tumor124
lung tumor58
lymphoma249
non-neoplasia93
ovarian tumor118
pancreatic tumor57
primitive neuroectodermal tumor of the CNS62
prostate cancer192
retinoblastoma236
skin tumor239
soft tissue/muscle tissue tumor87
uterine tumor210
Developmental Stage
TissuesTPM*
adult128
embryoid body271
blastocyst244
neonate289
fetus140
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue47.7
adrenal gland82.6
appendix91.5
bone marrow87.1
cerebral cortex49.6
colon64.2
duodenum83.6
esophagus44.8
gallbladder55.2
heart muscle42.8
kidney56.9
liver35.3
lung53.2
lymph node115.7
ovary65.8
pancreas21.5
placenta65
prostate50.2
salivary gland35.4
skin44.8
small intestine83.3
spleen65.7
stomach52.8
testis82.5
thyroid gland46.4
urinary bladder76.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverLow
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasLow
parathyroid glandLow
placentaHigh
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604477, gene) Chromobox homolog 3; CBX3OMIM


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