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> Protein (NX_Q13188)
Protein (NX_Q13188)
Protein
Gene SymbolSTK3 to neXtProt (NX_Q13188)
DescriptionSerine/threonine-protein kinase 3
Chromosome8
Location8q22.2 (99413631 ~ 99955055) to Ensembl
Sequene Features : Isoforms 2, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 50 8
2014-09-19protein level
2 40 8
2014-05-27protein level
2 40 9
2014-02-25protein level
1 40 9
2013-12-09protein level
1 34 9
2013-11-01protein level
1 33 9
2013-09-12protein level
1 33 9
2013-08-17protein level
1 33 9
2013-07-15protein level
1 16 8
2013-06-11protein level
1 16 8
2013-02-12protein level
1 8 12
2012-12-20protein level
1 7 12
2012-10-30protein level
1 9 12
2012-10-07protein level
1 9 12
2012-08-24protein level
1 4 12
2012-07-28protein level
1 4 12
2012-06-08protein level
1 11 12
2012-05-07protein level
1 11 12
2012-04-10protein level
1 11 12
2012-01-13protein level
1 12 12
2011-12-20protein level
1 12 12
2011-11-11protein level
1 12 12
2011-08-23protein level
1 11 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q13188-1
1 20 7 56264.8229
NX_Q13188-2
3 20 7 59423.3628
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-992580,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-992580,EBI-960081 RASSF2  
  .negative regulation of NIK/NF-kappaB signaling
.homeostasis of number of cells
.bone remodeling
  + 6 more...
.N/A .cytoplasm
.nucleus
3 EBI-992580,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
4 EBI-992580,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-992580,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
6 EBI-992580,EBI-1043216 SLMAP  
  .muscle contraction .N/A .sarcolemma
.integral component of plasma membrane
.microtubule organizing center
.smooth endoplasmic reticulum
7 EBI-992580,EBI-2845202 RASSF3  
  .signal transduction .identical protein binding .plasma membrane
.microtubule
.cytoplasm
8 EBI-992580,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
9 EBI-992580,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
10 EBI-992580,EBI-743184 GAD1  
  .response to drug
.neurotransmitter biosynthetic process
.protein-pyridoxal-5-phosphate linkage
  + 5 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.vesicle membrane
.plasma membrane
.intracellular
11 EBI-992580,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
12 EBI-992580,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
13 EBI-992580,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
14 EBI-992580,EBI-2933362 RASSF4  
  .signal transduction
.cell cycle
.N/A .N/A
15 EBI-992580,EBI-1017775 SAV1  
  .regulation of stem cell maintenance
.intestinal epithelial cell differentiation
.lung epithelial cell differentiation
  + 7 more...
.N/A .cytosol
.cytoplasm
.nucleus
16 EBI-992580,EBI-438698 RASSF1  
  .negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder133
blood16
bone27
bone marrow61
brain18
connective tissue53
ear124
embryonic tissue42
eye43
heart22
intestine8
kidney52
liver24
lung23
lymph22
lymph node22
mammary gland19
mouth90
muscle28
nerve64
ovary29
pancreas9
parathyroid194
pharynx24
placenta81
prostate36
skin9
stomach20
testis32
thyroid64
uterus47
vascular116
Health State
TissuesTPM*
normal36
bladder carcinoma113
breast (mammary gland) tumor10
chondrosarcoma36
colorectal tumor8
gastrointestinal tumor25
germ cell tumor15
glioma9
head and neck tumor59
kidney tumor29
leukemia10
liver tumor20
lung tumor9
lymphoma13
non-neoplasia51
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor55
Developmental Stage
TissuesTPM*
adult36
embryoid body28
blastocyst65
neonate32
fetus25
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.7
adrenal gland20.6
appendix13
bone marrow4.4
cerebral cortex5.1
colon9
duodenum6.6
esophagus20.7
gallbladder30.7
heart muscle14.2
kidney16.2
liver12.2
lung16.6
lymph node10.5
ovary36.6
pancreas6.3
placenta37
prostate21.5
salivary gland11.9
skin13.2
small intestine11
spleen8.8
stomach7.5
testis26.8
thyroid gland26.7
urinary bladder22.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605030, gene) Serine/threonine protein kinase 3; STK3OMIM


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